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Biochemistry (Moscow)

, Volume 73, Issue 3, pp 346–352 | Cite as

Evolution of DNA polymerase ι structure and function in eukaryotes

  • A. V. MakarovaEmail author
  • V. Z. Tarantul
  • L. V. Gening
Article

Abstract

Analysis of DNA polymerase ι (Pol ι) enzymic activity in different classes of eukaryotes has shown that error-prone activity of this enzyme can be found only in mammals, and that it is completely absent from organisms that are at lower stages of development. It was supposed that the emergence of the error-prone Pol ι activity in mammals is caused by structural alteration of the active center. Possible functions of error-prone Pol ι in higher eukaryotes are discussed.

Key words

DNA polymerase ι error-prone activity hypermutagenesis 

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Copyright information

© Pleiades Publishing, Ltd. 2008

Authors and Affiliations

  • A. V. Makarova
    • 1
    Email author
  • V. Z. Tarantul
    • 1
  • L. V. Gening
    • 1
  1. 1.Institute of Molecular GeneticsRussian Academy of SciencesMoscowRussia

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