Biochemistry (Moscow)

, Volume 73, Issue 2, pp 130–138 | Cite as

Light damaging action of all-trans-retinal and its derivatives on rhodopsin molecules in the photoreceptor membrane

  • M. Yu. LoginovaEmail author
  • Ye. V. Rostovtseva
  • T. B. Feldman
  • M. A. Ostrovsky
Accelerated Publication


We have reproduced the model system containing A2-rhodopsin, NR-PE, A2-PE, and ATR-dimer-PE in order to study photosensitized damage of rhodopsin within photoreceptor membranes of rod outer segments. We have demonstrated that irradiation of such a system with visible light (400–700 nm) distorts the most important functional property of native visual pigment—its ability to regenerate after addition of 11-cis-retinal in the dark. We have also shown that all-trans-retinal bound to membrane phospholipids and rhodopsin has less photosensitizing activity that free all-trans-retinal.

Key words

visual pigment rhodopsin all-trans-retinal photosensitizers photodamage 



ATP-binding cassette transporter






rhodopsin which has each of its three lysine residues modified with two all-trans-retinal molecules








rod outer segments


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Copyright information

© Pleiades Publishing, Ltd. 2008

Authors and Affiliations

  • M. Yu. Loginova
    • 1
    Email author
  • Ye. V. Rostovtseva
    • 1
  • T. B. Feldman
    • 1
  • M. A. Ostrovsky
    • 1
  1. 1.Emanuel’ Institute of Biochemical PhysicsRussian Academy of SciencesMoscowRussia

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