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Biochemistry (Moscow)

, Volume 73, Issue 1, pp 76–79 | Cite as

Effects of lipoic acid on citrate content, aconitate hydratase activity, and oxidative status during myocardial ischemia in rats

  • A. V. MakeevaEmail author
  • T. N. Popova
  • L. V. Matasova
  • I. N. Yama
Article

Abstract

The effects of lipoic acid on intensity of free radical reactions, citrate content, and aconitate hydratase during myocardial ischemia have been investigated. Treatment with lipoic acid normalized biochemiluminescence parameters and citrate level, which were increased in the myocardial pathology. Treatment with lipoic acid also increased specific activity of aconitate hydratase, which was decreased in myocardium and blood of animals with myocardial ischemia. Administration of lipoic acid decreased DNA fragmentation observed during myocardial ischemia. The data suggest that lipoic acid can be effectively used as a cardioprotector preventing the development of free radical oxidation during myocardial ischemia.

Key words

myocardial ischemia lipoic acid citrate aconitate hydratase 

Abbreviations

AH

aconitate hydratase

AsAT

aspartate aminotransferase

CD

conjugated dienes

CPK-MB

myocardial MB isoform of creatine phosphokinase

LPO

lipid peroxidation

ROS

reactive oxygen species

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Copyright information

© Pleiades Publishing, Ltd. 2008

Authors and Affiliations

  • A. V. Makeeva
    • 1
    Email author
  • T. N. Popova
    • 1
  • L. V. Matasova
    • 1
  • I. N. Yama
    • 1
  1. 1.Faculty of Biology and Soil SciencesVoronezh State UniversityVoronezhRussia

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