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Biochemistry (Moscow)

, Volume 73, Issue 1, pp 1–13 | Cite as

Cysteine proteinases of microorganisms and viruses

  • G. N. RudenskayaEmail author
  • D. V. Pupov
Review

Abstract

This review considers properties of secreted cysteine proteinases of protozoa, bacteria, and viruses and presents information on the contemporary taxonomy of cysteine proteinases. Literature data on the structure and physicochemical and enzymatic properties of these enzymes are reviewed. High interest in cysteine proteinases is explained by the discovery of these enzymes mostly in pathogenic organisms. The role of the proteinases in pathogenesis of several severe diseases of human and animals is discussed.

Key words

cysteine proteinases properties protozoa bacteria viruses 

Abbreviations

DTT

dithiothreitol

FMDV

foot-and-mouth disease virus

RDRP

RNA-dependent RNA polymerase

TLCK

tosyl-L-lysine chloromethyl ketone

TPCK

tosyl-L-phenylalanine chloromethyl ketone

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References

  1. 1.
    Rosenthal, P. J., McKerrow, J. H., Aikawa, M., Nagasawa, H., and Leech, J. H. (1988) J. Clin. Invest., 82, 1560–1566.CrossRefPubMedGoogle Scholar
  2. 2.
    Shenai, B. R., Sijwali, P. S., Singh, A., and Rosenthal, P. J. (2000) J. Biol. Chem., 275, 29000–29010.CrossRefPubMedGoogle Scholar
  3. 3.
    Rosenthal, P. J., and Nelson, R. G. (1992) Mol. Biochem. Parasitol., 51, 143–152.CrossRefPubMedGoogle Scholar
  4. 4.
    Hanspal, M. (2000) Biochim. Biophys. Acta, 1493, 242–245.PubMedGoogle Scholar
  5. 5.
    Sijwali, P. S., Shenai, B. R., Gut, J., Singh, A., and Rosenthal, P. J. (2001) Biochem. J., 360, 481–489.CrossRefPubMedGoogle Scholar
  6. 6.
    Na, B. K., Shenai, B. R., Sijwali, P. S., Choe, Y., Pandey, K. C., Singh, A., Craik, C. S., and Rosenthal, P. J. (2004) Biochem. J., 378, 529–538.CrossRefPubMedGoogle Scholar
  7. 7.
    Tannich, E., Scholze, H., Nickel, R., and Horstmann, R. D. (1991) J. biol. Chem., 266, 4798–4803.PubMedGoogle Scholar
  8. 8.
    Scholze, H., and Schulte, W. (1988) Biomed. Biochim. Acta, 47, 115–123.PubMedGoogle Scholar
  9. 9.
    Luaces, A. L., and Barrett, A. J. (1988) Biochem. J., 250, 903–909.PubMedGoogle Scholar
  10. 10.
    Li, E., Yang, W. G., Zhang, T., and Stanley, S. L., Jr. (1995) Infect. Immun., 63, 4150–4153.PubMedGoogle Scholar
  11. 11.
    Jacobs, T., Bruchhaus, I., Dandekar, T., Tannich, E., and Leippe, M. (1998) Mol. Microbiol., 27, 269–276.CrossRefPubMedGoogle Scholar
  12. 12.
    Keene, W. E., Petitt, M. G., Allen, S., and McKerrow, J. H. (1986) J. Exp. Med., 163, 536–549.CrossRefPubMedGoogle Scholar
  13. 13.
    Spinella, S., Levavasseur, E., Petek, F., and Rigothier, M. C. (1999) Eur. J. Biochem., 266, 170–180.CrossRefPubMedGoogle Scholar
  14. 14.
    Bruchhaus, I., Jacobs, T., Leippe, M., and Tannich, E. (1996) Mol. Microbiol., 22, 255–263.CrossRefPubMedGoogle Scholar
  15. 15.
    Willhoeft, U., Hamann, L., and Tannich, E. (1999) Infect. Immun., 67, 5925–5929.PubMedGoogle Scholar
  16. 16.
    Que, X., and Reed, S. L. (2000) Clin. Microbiol. Rev., 13, 196–206.CrossRefPubMedGoogle Scholar
  17. 17.
    Serveau, C., Lalmanach, G., Juliano, M. A., Scharfstein, J., Juliano, L., and Gauthier, F. (1996) Biochem. J., 313, 951–956.PubMedGoogle Scholar
  18. 18.
    Gillmor, S. A., Craik, C. S., and Fletterick, R. J. (1997) Protein Sci., 6, 1603–1611.CrossRefPubMedGoogle Scholar
  19. 19.
    Turk, B., Stoka, V., Turk, V., Johansson, G., Cazzulo, J. J., and Bjork, I. (1996) FEBS Lett., 391, 109–112.CrossRefPubMedGoogle Scholar
  20. 20.
    Stoka, V., Nycander, M., Lenarcic, B., Labriola, C., Cazzulo, J. J., Bjork, I., and Turk, V. (1995) FEBS Lett., 370, 101–104.CrossRefPubMedGoogle Scholar
  21. 21.
    Martinez, J., Campetella, O., Frasch, A. C., and Cazzulo, J. J. (1993) Immunol. Lett., 35, 191–196.CrossRefPubMedGoogle Scholar
  22. 22.
    McGrath, M. E., Eakin, A. E., Engel, J. C., McKerrow, J. H., Craik, C. S., and Fletterick, R. J. (1995) J. Mol. Biol., 247, 251–259.CrossRefPubMedGoogle Scholar
  23. 23.
    Yokoyama-Yasunaka, J. K., Pral, E. M., Oliveira, O. C., Jr., Alfieri, S. C., and Stolf, A. M. (1994) Acta Trop., 57, 307–315.CrossRefPubMedGoogle Scholar
  24. 24.
    Cazzulo, J. J., Stoka, V., and Turk, V. (1997) Biol. Chem., 378, 1–10.CrossRefPubMedGoogle Scholar
  25. 25.
    Robertson, C. D., and Coombs, G. H. (1990) Mol. Biochem. Parasitol., 42, 269–276.CrossRefPubMedGoogle Scholar
  26. 26.
    Souza, A. E., Waugh, S., Coombs, G. H., and Mottram, J. C. (1992) FEBS Lett., 311, 124–127.CrossRefPubMedGoogle Scholar
  27. 27.
    Mottram, J. C., Souza, A. E., Hutchison, J. E., Carter, R., Frame, M. J., and Coombs, G. H. (1996) Proc. Natl. Acad. Sci. USA, 93, 6008–6013.CrossRefPubMedGoogle Scholar
  28. 28.
    Mallinson, D. J., Lockwood, B. C., Coombs, G. H., and North, M. J. (1994) Microbiology, 140, 2725–2735.CrossRefPubMedGoogle Scholar
  29. 29.
    Mallinson, D. J., Livingstone, J., Appleton, K. M., Lees, S. J., Coombs, G. H., and North, M. J. (1995) Microbiology, 141, 3077–3085.CrossRefPubMedGoogle Scholar
  30. 30.
    Parenti, D. M. (1989) J. Infect. Dis., 160, 1076–1080.PubMedGoogle Scholar
  31. 31.
    Williams, A. G., and Coombs, G. H. (1995) Int. J. Parasitol., 25, 771–778.CrossRefPubMedGoogle Scholar
  32. 32.
    Arroyo, R., and Alderete, J. F. (1989) Infect. Immun., 57, 2991–2997.PubMedGoogle Scholar
  33. 33.
    Provenzano, D., and Alderete, J. F. (1995) Infect. Immun., 63, 3388–3395.PubMedGoogle Scholar
  34. 34.
    Potempa, J., Dubin, A., Korzus, G., and Travis, J. (1988) J. Biol. Chem., 263, 2664–2667.PubMedGoogle Scholar
  35. 35.
    Rzychon, M., Sabat, A., Kosowska, K., Potempa, J., and Dubin, A. (2003) Mol. Microbiol., 49, 1051–1066.CrossRefPubMedGoogle Scholar
  36. 36.
    Filipek, R., Rzychon, M., Oleksy, A., Gruca, M., Dubin, A., Potempa, J., and Bochtler, M. (2003) J. Biol. Chem., 278, 40959–40966.CrossRefPubMedGoogle Scholar
  37. 37.
    Kembhavi, A. A., Buttle, D. J., Rauber, P., and Barrett, A. J. (1991) FEBS Lett., 283, 277–280.CrossRefPubMedGoogle Scholar
  38. 38.
    Gilles, A. M., Imhoff, J. M., and Keil, B. (1979) J. Biol. Chem., 254, 1462–1468.PubMedGoogle Scholar
  39. 39.
    Ullmann, D., and Jakubke, H. D. (1994) Eur. J. Biochem., 223, 865–872.CrossRefPubMedGoogle Scholar
  40. 40.
    Dargatz, H., Diefenthal, T., Witte, V., Reipen, G., and von Wettstein, D. (1993) Mol. Gen. Genet., 240, 140–145.CrossRefPubMedGoogle Scholar
  41. 41.
    Witte, V., Wolf, N., and Dargatz, H. (1996) Curr. Microbiol., 33, 281–286.CrossRefPubMedGoogle Scholar
  42. 42.
    Porter, W. H., Cunningham, L. W., and Mitchell, W. M. (1971) J. Biol. Chem., 246, 7675–7682.PubMedGoogle Scholar
  43. 43.
    Siffert, O., Emod, I., and Keil, B. (1976) FEBS Lett., 66, 114–119.CrossRefPubMedGoogle Scholar
  44. 44.
    Gusman, H., Grogan, J., Kagan, H. M., Troxler, R. F., and Oppenheim, F. G. (2001) FEBS Lett., 489, 97–100.CrossRefPubMedGoogle Scholar
  45. 45.
    Potempa, J., Sroka, A., Imamura, T., and Travis, J. (2003) Curr. Protein Pept. Sci., 4, 397–407.CrossRefPubMedGoogle Scholar
  46. 46.
    Potempa, J., and Travis, J. (1996) Acta Biochim. Pol., 43, 455–465.PubMedGoogle Scholar
  47. 47.
    Kadowaki, T., Yoneda, M., Okamoto, K., Maeda, K., and Yamamoto, K. (1994) J. Biol. Chem., 269, 21371–21378.PubMedGoogle Scholar
  48. 48.
    Pike, R. N., Potempa, J., McGraw, W., Coetzer, T. H., and Travis, J. (1996) J. Bacteriol., 178, 2876–2882.PubMedGoogle Scholar
  49. 49.
    Potempa, J., Mikolajczyk-Pawlinska, J., Brassell, D., Nelson, D., Thogersen, I. B., Enghild, J. J., and Travis, J. (1998) J. Biol. Chem., 273, 21648–21657.CrossRefPubMedGoogle Scholar
  50. 50.
    Pavloff, N., Pemberton, P. A., Potempa, J., Chen, W. C., Pike, R. N., Prochazka, V., Kiefer, M. C., Travis, J., and Barr, P. J. (1997) J. Biol. Chem., 272, 1595–1600.CrossRefPubMedGoogle Scholar
  51. 51.
    Eichinger, A., Beisel, H. G., Jacob, U., Huber, R., Medrano, F. J., Banbula, A., Potempa, J., Travis, J., and Bode, W. (1999) EMBO J., 18, 5453–5462.CrossRefPubMedGoogle Scholar
  52. 52.
    Imamura, T., Banbula, A., Pereira, P. J., Travis, J., and Potempa, J. (2001) J. Biol. Chem., 276, 18984–18991.CrossRefPubMedGoogle Scholar
  53. 53.
    Wingrove, J. A., DiScipio, R. G., Chen, Z., Potempa, J., Travis, J., and Hugli, T. E. (1992) J. Biol. Chem., 267, 18902–18907.PubMedGoogle Scholar
  54. 54.
    Nelson, D., Potempa, J., Kordula, T., and Travis, J. (1999) J. Biol. Chem., 274, 12245–12251.CrossRefPubMedGoogle Scholar
  55. 55.
    Gerwin, B. I., Stein, W. H., and Moore, S. (1966) J. Biol. Chem., 241, 3331–3339.PubMedGoogle Scholar
  56. 56.
    Liu, T. Y., and Elliott, S. D. (1965) Nature, 206, 33–34.CrossRefPubMedGoogle Scholar
  57. 57.
    Kagawa, T. F., Cooney, J. C., Baker, H. M., McSweeney, S., Liu, M., Gubba, S., Musser, J. M., and Baker, E. N. (2000) Proc. Natl. Acad. Sci. USA, 97, 2235–2240.CrossRefPubMedGoogle Scholar
  58. 58.
    Lukomski, S., Montgomery, C. A., Rurangirwa, J., Geske, R. S., Barrish, J. P., Adams, G. J., and Musser, J. M. (1999) Infect. Immun., 67, 1779–1788.PubMedGoogle Scholar
  59. 59.
    Kapur, V., Topouzis, S., Majesky, M. W., Li, L. L., Hamrick, M. R., Hamill, R. J., Patti, J. M., and Musser, J. M. (1993) Microb. Pathog., 15, 327–346.CrossRefPubMedGoogle Scholar
  60. 60.
    Collin, M., and Olsen, A. (2001) Infect. Immun., 69, 7187–7189.CrossRefPubMedGoogle Scholar
  61. 61.
    Kapur, V., Majesky, M. W., Li, L. L., Black, R. A., and Musser, J. M. (1993) Proc. Natl. Acad. Sci. USA, 90, 7676–7680.CrossRefPubMedGoogle Scholar
  62. 62.
    Li, F., Browning, G. F., Studdert, M. J., and Crabb, B. S. (1996) Proc. Natl. Acad. Sci. USA, 93, 990–995.CrossRefPubMedGoogle Scholar
  63. 63.
    Roberts, P. J., and Belsham, G. J. (1995) Virology, 213, 140–146.CrossRefPubMedGoogle Scholar
  64. 64.
    Guarne, A., Kirchweger, R., Verdaguer, N., Liebig, H. D., Blaas, D., Skern, T., and Fita, I. (1996) Protein Sci., 5, 1931–1933.CrossRefPubMedGoogle Scholar
  65. 65.
    Medina, M., Domingo, E., Brangwyn, J. K., and Belsham, G. J. (1993) Virology, 194, 355–359.CrossRefPubMedGoogle Scholar
  66. 66.
    Piccone, M. E., Rieder, E., Mason, P. W., and Grubman, M. J. (1995) J. Virol., 69, 5376–5382.PubMedGoogle Scholar
  67. 67.
    Brown, C. C., Piccone, M. E., Mason, P. W., McKenna, T. S., and Grubman, M. J. (1996) J. Virol., 70, 5638–5641.PubMedGoogle Scholar
  68. 68.
    Bredenbeek, P. J., Pachuk, C. J., Noten, A. F., Charite, J., Luytjes, W., Weiss, S. R., and Spaan, W. J. (1990) Nucleic Acids Res., 18, 1825–1832.CrossRefPubMedGoogle Scholar
  69. 69.
    Gorbalenya, A. E., Koonin, E. V., and Lai, M. M. (1991) FEBS Lett., 288, 201–205.CrossRefPubMedGoogle Scholar
  70. 70.
    Bonilla, P. J., Hughes, S. A., Pinon, J. D., and Weiss, S. R. (1995) Virology, 209, 489–497.CrossRefPubMedGoogle Scholar
  71. 71.
    Kim, J. C., Spence, R. A., Currier, P. F., Lu, X., and Denison, M. R. (1995) Virology, 208, 1–8.CrossRefPubMedGoogle Scholar
  72. 72.
    Den Boon, J. A., Faaberg, K. S., Meulenberg, J. J., Wassenaar, A. L., Plagemann, P. G., Gorbalenya, A. E., and Snijder, E. J. (1995) J. Virol., 69, 4500–4505.Google Scholar
  73. 73.
    De Groot, R. J., Hardy, W. R., Shirako, Y., and Strauss, J. H. (1990) EMBO J., 9, 2631–2638.PubMedGoogle Scholar
  74. 74.
    Hardy, W. R., and Strauss, J. H. (1989) J. Virol., 63, 4653–4664.PubMedGoogle Scholar
  75. 75.
    Strauss, E. G., de Groot, R. J., Levinson, R., and Strauss, J. H. (1992) Virology, 191, 932–940.CrossRefPubMedGoogle Scholar
  76. 76.
    Lemm, J. A., Rumenapf, T., Strauss, E. G., Strauss, J. H., and Rice, C. M. (1994) EMBO J., 13, 2925–2934.PubMedGoogle Scholar
  77. 77.
    Shirako, Y., and Strauss, J. H. (1994) J. Virol., 68, 1874–1885.PubMedGoogle Scholar
  78. 78.
    Hanecak, R., Semler, B. L., Ariga, H., Anderson, C. W., and Wimmer, E. (1984) Cell, 37, 1063–1073.CrossRefPubMedGoogle Scholar
  79. 79.
    Brenner, S. (1988) Nature, 334, 528–530.CrossRefPubMedGoogle Scholar
  80. 80.
    Ypma-Wong, M. F., Filman, D. J., Hogle, J. M., and Semler, B. L. (1988) J. Biol. Chem., 263, 17846–17856.PubMedGoogle Scholar
  81. 81.
    Clark, M. E., Hammerle, T., Wimmer, E., and Dasgupta, A. (1991) EMBO J., 10, 2941–2947.PubMedGoogle Scholar
  82. 82.
    Clark, M. E., Lieberman, P. M., Berk, A. J., and Dasgupta, A. (1993) Mol. Cell. Biol., 13, 1232–1237.PubMedGoogle Scholar
  83. 83.
    Joachims, M., Harris, K. S., and Etchison, D. (1995) Virology, 211, 451–461.CrossRefPubMedGoogle Scholar
  84. 84.
    Tesar, M., and Marquardt, O. (1990) Virology, 174, 364–374.CrossRefPubMedGoogle Scholar
  85. 85.
    Andino, R., Rieckhof, G. E., Achacoso, P. L., and Baltimore, D. (1993) EMBO J., 12, 3587–3598.PubMedGoogle Scholar
  86. 86.
    Krausslich, H. G., Nicklin, M. J., Toyoda, H., Etchison, D., and Wimmer, E. (1987) J. Virol., 61, 2711–2718.PubMedGoogle Scholar
  87. 87.
    Bazan, J. F., and Fletterick, R. J. (1988) Proc. Natl. Acad. Sci. USA, 85, 7872–7876.CrossRefPubMedGoogle Scholar
  88. 88.
    Sommergruber, W., Ahorn, H., Zophel, A., Maurer-Fogy, I., Fessl, F., Schnorrenberg, G., Liebig, H. D., Blaas, D., Kuechler, E., and Skern, T. (1992) J. Biol. Chem., 267, 22639–22644.PubMedGoogle Scholar
  89. 89.
    Sommergruber, W., Ahorn, H., Klump, H., Seipelt, J., Zoephel, A., Fessl, F., Krystek, E., Blaas, D., Kuechler, E., Liebig, H. D., et al. (1994) Virology, 198, 741–745.CrossRefPubMedGoogle Scholar

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© Pleiades Publishing, Ltd. 2008

Authors and Affiliations

  1. 1.Faculty of ChemistryLomonosov Moscow State UniversityMoscowRussia
  2. 2.Faculty of BiologyLomonosov Moscow State UniversityMoscowRussia

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