Biochemistry (Moscow)

, Volume 72, Issue 8, pp 797–808 | Cite as

Lipid second messengers and cell signaling in vascular wall

  • N. V. Prokazova
  • N. N. Samovilova
  • N. K. Golovanova
  • E. V. Gracheva
  • A. A. Korotaeva
  • E. R. Andreeva


Agonists of cellular receptors, such as receptor tyrosine kinases, G protein-coupled receptors, cytokine receptors, etc., activate phospholipases (Cγ, Cβ, A2, D), sphingomyelinase, and phosphatidylinositol-3-kinase. This produces active lipid metabolites, some of which are second messengers: inositol trisphosphate, diacylglycerides, ceramide, and phosphatidylinositol 3,4,5-trisphosphate. These universal mechanisms are involved in signal transduction to maintain blood vessel functions: regulation of vasodilation and vasoconstriction, mechanical stress resistance, and anticoagulant properties of the vessel lumen surface. Different signaling pathways realized through lipid second messengers interact to one another and modulate intracellular events. In early stages of atherogenesis, namely, accumulation of low density lipoproteins in the vascular wall, cascades of pro-atherogenic signal transduction are triggered through lipid second messengers. This leads to atherosclerosis, the general immuno-inflammatory disease of the vascular system.

Key words

phospholipases phospholipids inositol 1,4,5-trisphosphate phosphatidylinositol 3,4,5-trisphosphate diacyl-glycerides ceramide endothelial and smooth muscle vascular cells 



angiotensin II receptor


cytosolic phospholipase A2




endothelial NO synthase


extracellular signal-regulated kinases




focal adhesion kinase


high density lipoproteins


inositol trisphosphate


low density lipoproteins


mitogen-activated protein kinases


myosin light chains


oxidized LDL


platelet-derived growth factor


phosphatidylinositol 3-kinase


protein kinase B/Akt


protein kinase C


phospholipase A2


phospholipase D


phosphatidylinositol 3-monophosphate


phos-phatidylinositol 3,4-bisphosphate


phos-phatidylinositol 3,5-bisphosphate


phos-phatidylinositol 4,5-bisphosphate


phos-phatidylinositol 3,4,5-trisphosphate


reactive oxygen species


stress-activated protein kinase


smooth muscle cells




trans-forming growth factor-β


tumor necrosis factor-α


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Copyright information

© Pleiades Publishing, Ltd. 2007

Authors and Affiliations

  • N. V. Prokazova
    • 1
  • N. N. Samovilova
    • 1
  • N. K. Golovanova
    • 1
  • E. V. Gracheva
    • 1
  • A. A. Korotaeva
    • 1
  • E. R. Andreeva
    • 1
  1. 1.Institute of Experimental CardiologyRussian Cardiology Research CenterMoscowRussia

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