Biochemistry (Moscow)

, Volume 72, Issue 2, pp 132–145 | Cite as

Redox regulation of cellular functions

  • O. N. OktyabrskyEmail author
  • G. V. Smirnova


Maintenance of normal intracellular redox status plays an important role in such processes as DNA synthesis, gene expression, enzymatic activity, and others. In addition, it is clear that changes in the redox status of intracellular content and individual molecules, resulting from stress or intrinsic cellular activity, are involved in the regulation of different processes in cells. Small changes in intracellular levels of reactive oxygen species participate in intracellular signaling. Thiol-containing molecules, such as glutathione, thioredoxins, glutaredoxins, and peroxiredoxins, also play an important role in maintaining redox homeostasis and redox regulation. This review attempts to summarize the current knowledge about redox regulation in different cell types.

Key words

redox regulation reactive oxygen species mitochondria apoptosis 





reduced form of glutathione


oxidized form of glutathione


mitogen-activated protein kinases


peroxiredoxins or thioredoxin peroxidases


small G-protein


reactive oxygen species


thioredoxin reductase




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  1. 1.
    Schafer, F. Q., and Buettner, G. (2001) Free Rad. Biol. Med., 30, 1191–1212.PubMedCrossRefGoogle Scholar
  2. 2.
    Cross, A. R., and Jones, O. T. G. (1991) Biochim. Biophys. Acta, 1057, 281–298.PubMedCrossRefGoogle Scholar
  3. 3.
    Skulachev, V. P. (1998) Biochim. Biophys. Acta, 1363, 100–124.PubMedCrossRefGoogle Scholar
  4. 4.
    Cadenas, E. (2004) Mol. Aspects Med., 25, 17–26.PubMedCrossRefGoogle Scholar
  5. 5.
    Andreyev, A. Yu., Kushnareva, Yu. E., and Starkov, A. A. (2005) Biochemistry (Moscow), 70, 200–214.CrossRefGoogle Scholar
  6. 6.
    Jezek, P., and Hlavata, L. (2005) Int. J. Biochem. Cell. Biol., 37, 2478–2503.PubMedCrossRefGoogle Scholar
  7. 7.
    Gamaley, I. A., and Klyubin, I. V. (1999) Int. Rev. Cytol., 188, 203–255.PubMedGoogle Scholar
  8. 8.
    Boldyrev, A. A. (1995) Biochemistry (Moscow), 60, 1173–1178.Google Scholar
  9. 9.
    Nakamura, H., Nakamura, K., and Yodoi, J. (1997) Annu. Rev. Immunol., 15, 351–369.PubMedCrossRefGoogle Scholar
  10. 10.
    Thannickal, V. J., and Fanburg, B. L. (2000) Am. J. Physiol. Lung Cell. Mol. Physiol., 279, L1005–L1028.PubMedGoogle Scholar
  11. 11.
    Turpaev, K. T. (2002) Biochemistry (Moscow), 67, 281–292.CrossRefGoogle Scholar
  12. 12.
    Pastori, G. M., and Foyer, C. H. (2002) Plant Physiol., 129, 460–468.PubMedCrossRefGoogle Scholar
  13. 13.
    Stone, J. R. (2004) Arch. Biochem. Biophys., 422, 119–124.PubMedCrossRefGoogle Scholar
  14. 14.
    Antunes, F., and Cadenas, E. (2001) Free Rad. Biol. Med., 30, 1008–1018.PubMedCrossRefGoogle Scholar
  15. 15.
    Toledano, M. B., Delaunay, A., Monceau, L., and Tacnet, F. (2004) Trends Biochem. Sci., 29, 351–357.PubMedCrossRefGoogle Scholar
  16. 16.
    Poole, L. B., Karplus, P. A., and Claiborne, A. (2004) Annu. Rev. Pharmacol. Toxicol., 44, 325–347.PubMedCrossRefGoogle Scholar
  17. 17.
    Giaccia, A. J., Simon, M. C., and Johnson, R. (2004) Genes Dev., 18, 2183–2194.PubMedCrossRefGoogle Scholar
  18. 18.
    Bailey-Serres, J., and Chang, R. (2005) Ann. Botany, 96, 507–518.CrossRefGoogle Scholar
  19. 19.
    Semenza, G. L. (2004) Physiology, 19, 176–182.PubMedCrossRefGoogle Scholar
  20. 20.
    Chandel, N. S., McClintock, D. S., Feliciano, C. E., Wood, T. M., Melendez, J. A., Rodriguez, A. M., and Schumacker, P. T. (2000) J. Biol. Chem., 275, 25130–25138.PubMedCrossRefGoogle Scholar
  21. 21.
    Bell, E. L., Emerling, B. M., and Chandel, N. S. (2005) Mitochondrion, 5, 322–332.PubMedCrossRefGoogle Scholar
  22. 22.
    Lopez-Barneo, J., Toro, R., Levitsky, K. L., Chiara, M. D., and Ortega Saenz, G. P. (2003) J. Appl. Physiol., 96, 1187–1195.CrossRefGoogle Scholar
  23. 23.
    Zitomer, R. S., and Lowry, C. V. (1992) Microbiol. Rev., 56, 1–11.PubMedGoogle Scholar
  24. 24.
    Kwast, K. E., Burke, P., and Poyton, R. O. (1998) J. Exp. Biol., 201, 1177–1195.PubMedGoogle Scholar
  25. 25.
    Hon, T., Dodd, A., Dirmeier, Gorman, N., Sinclair, P. R., Zhang, L., and Poyton, R. O. (2003) J. Biol. Chem., 278, 50771–50780.PubMedCrossRefGoogle Scholar
  26. 26.
    Satroutdinov, A. D., Kuriyama, H., and Kobayashi, H. (1992) FEMS Microbiol. Lett., 77, 261–267.PubMedCrossRefGoogle Scholar
  27. 27.
    Sohn, H. Y., Murray, D. B., and Kuriyama, H. (2000) Yeast, 16, 1185–1190.PubMedCrossRefGoogle Scholar
  28. 28.
    Murray, D. B., Engelen, F., Lloyd, D., and Kuriyama, H. (1999) Microbiology, 145, 2739–2745.PubMedGoogle Scholar
  29. 29.
    Klevecz, R. R., Bolen, J., Forrest, G., and Murray, D. B. (2004) Proc. Natl. Acad. Sci. USA, 101, 1200–1205.PubMedCrossRefGoogle Scholar
  30. 30.
    Tu, B., Kudlicki, A., Rowicka, M., and McKnight, S. L. (2005) Science, 310, 1152–1158.PubMedCrossRefGoogle Scholar
  31. 31.
    Kiley, P. J., and Beinert, H. (1999) FEMS Microbiol. Rev., 22, 341–352.CrossRefGoogle Scholar
  32. 32.
    Unden, G., Achebach, S., Holighaus, G., Tran, H. G., Wackwitz, B., and Zeuner, Y. (2002) J. Mol. Microbiol. Biotechnol., 4, 263–268.PubMedGoogle Scholar
  33. 33.
    Alexeeva, S., Hellingwerf, K. J., and Mattos, M. J. T. (2003) J. Bacteriol., 185, 204–209.PubMedCrossRefGoogle Scholar
  34. 34.
    Alexeeva, S., Kort, B., Sawers, G., Hellingwerf, K. J., and Mattos, M. J. T. (2000) J. Bacteriol., 182, 4934–4940.PubMedCrossRefGoogle Scholar
  35. 35.
    Malpica, R., Franco, B., Rodriguez, C., Kwon, O., and Georgellis, D. (2004) Proc. Natl. Acad. Sci. USA, 101, 13318–13323.PubMedCrossRefGoogle Scholar
  36. 36.
    Taylor, B. L., and Zhulin, I. B. (1999) Microbiol. Mol. Biol. Rev., 63, 479–506.PubMedGoogle Scholar
  37. 37.
    Meister, A., and Anderson, M. E. (1983) Ann. Rev. Biochem., 52, 711–760.PubMedCrossRefGoogle Scholar
  38. 38.
    Del Bello, B., Paolicchi, A., Comporti, M., Pompella, A., and Maellaro, E. (1999) FASEB J., 13, 69–79.PubMedGoogle Scholar
  39. 39.
    Paolicchi, A., Dominici, S., Pieri, L., Maellaro, E., and Pompella, A. (2002) Biochem. Pharmacol., 64, 1027–1035.PubMedCrossRefGoogle Scholar
  40. 40.
    Klatt, P., and Lamas, S. (2000) Eur. J. Biochem., 267, 4928–4944.PubMedCrossRefGoogle Scholar
  41. 41.
    Fratelli, M., Demol, H., Puype, M., Casagrande, S., Villa, P., Eberini, I., Vandekerckhove, J., Gianazza E., and Ghezzi, P. (2003) Proteomics, 7, 1154–1161.CrossRefGoogle Scholar
  42. 42.
    Thomas, J. A., and Mallis, R. J. (2001) Exp. Gerontol., 36, 1519–1526.PubMedCrossRefGoogle Scholar
  43. 43.
    Shelton, M. D., Chock, P. B., and Mieyal, J. J. (2005) Antiox. Redox. Signal., 7, 348–366.CrossRefGoogle Scholar
  44. 44.
    Shenton, D., Perrone, G., Quinn, K. A., Dawes, I. W., and Grant, C. M. (2002) J. Biol. Chem., 277, 16853–16859.PubMedCrossRefGoogle Scholar
  45. 45.
    Lind, C., Gerdes, R., Schuppe-Koistinen, I., and Cotgreave, I. A. (1998) Biochem. Biophys. Res. Commun., 247, 481–486.PubMedCrossRefGoogle Scholar
  46. 46.
    Casagrande, S., Bonetto, V., Fratelli, M., Gianazza, E., Eberini, I., Massignan, T., Salmona, M., Chang, G., Holmgren, A., and Ghezzi, P. (2002) Proc. Natl. Acad. Sci. USA, 99, 9745–9749.PubMedCrossRefGoogle Scholar
  47. 47.
    Klatt, P., Molina, E. P., De Lacoba, M. G., Padilla, C. A., Martinez-Galesteo, E., Barcena, J. A., and Lamas, S. (1999) FASEB J., 13, 1481–1490.PubMedGoogle Scholar
  48. 48.
    Molina, E. P., Klatt, P., Vazquez, J., Marina, A., De Lacoba, M. G., Perez-Sala, D., and Lamas, S. (2001) Biochemistry, 40, 14134–14142.CrossRefGoogle Scholar
  49. 49.
    Obin, M., Shang, F., Gong, X., Handelman, G., Blumberg, J., and Taylor, A. (1998) FASEB J., 12, 561–569.PubMedGoogle Scholar
  50. 50.
    Humphries, K. M., Juliano, C., and Taylor, S. S. (2002) J. Biol. Chem., 277, 43505–43511.PubMedCrossRefGoogle Scholar
  51. 51.
    Holmgren, A. (1989) J. Biol. Chem., 264, 13963–13966.PubMedGoogle Scholar
  52. 52.
    Kern, J., and Kehrer, J. P. (2005) Frontiers Biosci., 10, 1727–1738.Google Scholar
  53. 53.
    Ritz, D., and Beckwith, J. (2001) Annu. Rev. Microbiol., 55, 21–48.PubMedCrossRefGoogle Scholar
  54. 54.
    Chae, H. Z., Hang, S. W., and Rhee, S. G. (1999) Meth. Enzymol., 300, 219–226.PubMedGoogle Scholar
  55. 55.
    Hofmann, B. (2002) Biol. Chem., 383, 347–364.PubMedCrossRefGoogle Scholar
  56. 56.
    Wood, Z. A., Schroder, E., Harris, J. R., and Poole, L. B. (2003) Trends Biochem. Sci., 28, 32–40.PubMedCrossRefGoogle Scholar
  57. 57.
    Seaver, L. C., and Imlay, J. A. (2001) J. Bacteriol., 183, 7173–7181.PubMedCrossRefGoogle Scholar
  58. 58.
    Immenschuh, S., and Baumgart-Vogt, E. (2005) Antiox. Redox. Signal., 7, 768–777.CrossRefGoogle Scholar
  59. 59.
    Seo, M. S., Kang, S. W., Kim, K., Baines, I. C., Lee, T. H., and Rhee, S. G. (2000) J. Biol. Chem., 275, 20346–20354.PubMedCrossRefGoogle Scholar
  60. 60.
    Poole, L. B., Karplus, P. A., and Claiborne, A. (2004) Annu. Rev. Pharmacol. Toxicol., 44, 325–347.PubMedCrossRefGoogle Scholar
  61. 61.
    Saurin, A. T., Neubert, H., Brennan, J. P., and Eaton, P. (2004) Proc. Natl. Acad. Sci. USA, 101, 17982–17987.PubMedCrossRefGoogle Scholar
  62. 62.
    Biteau, B., Labarre, J., and Toledano, M. B. (2003) Nature, 425, 980–984.PubMedCrossRefGoogle Scholar
  63. 63.
    Budanov, A. V., Sablina, A. A., Feinstein, E., Koonin, E. V., and Chumakov, P. M. (2004) Science, 304, 596–600.PubMedCrossRefGoogle Scholar
  64. 64.
    Chang, T. S., Jeong, W., Woo, H. A., Lee, S. M., Park, S., and Rhee, S. G. (2004) J. Biol. Chem., 279, 50994–51001.PubMedCrossRefGoogle Scholar
  65. 65.
    Woo, H. A., Jeong, W., Chang, T. S., Park, K. J., Park, S. J., Yang, J. S., and Rhee, S. G. (2005) J. Biol. Chem., 280, 3125–3128.PubMedCrossRefGoogle Scholar
  66. 66.
    Rhee, S. G., Chae, H. Z., and Kim, K. (2005) Free Rad. Biol. Med., 38, 1543–1552.PubMedCrossRefGoogle Scholar
  67. 67.
    Matsuzawa, A., and Ichijo, H. (2005) Antiox. Redox Signal., 7, 472–481.CrossRefGoogle Scholar
  68. 68.
    Irani, K., Xia, Y., Zweier, J. L., Sollott, S. J., Der, C. J., Fearon, E. R., Sundaresan, M., Finkel, T., and Goldschmidt-Clermont, P. J. (1997) Science, 275, 1649–1652.PubMedCrossRefGoogle Scholar
  69. 69.
    Filomeni, G., Rotilio, G., and Ciriolo, M. R. (2002) Biochem. Pharmacol., 64, 1057–1064.PubMedCrossRefGoogle Scholar
  70. 70.
    Liu, H., Nishitoh, H., Ichijo, H., and Kyriakis, J. M. (2000) Mol. Cell Biol., 20, 2198–2208.PubMedCrossRefGoogle Scholar
  71. 71.
    Saitoh, M., Nishitoh, H., Fujii, M., Takeda, K., Tobiume, K., Sawada, Y., Kawabata, M., Miyazono, K., and Ichijo, H. (1998) EMBO J., 17, 2596–2606.PubMedCrossRefGoogle Scholar
  72. 72.
    Adler, V., Yin, Z., Fuchs, S. Y., Benezra, M., Rosario, L., Tew, K. D., Pincus, M. R., Sardana, M., Henderson, C. J., Wolf, C. R., Davis, R. J., and Ronai, Z. (1999) EMBO J., 18, 1321–1334.PubMedCrossRefGoogle Scholar
  73. 73.
    Gabbita, S. P., Robinson, K. A., Stewart, C. A., Foyd, R. A., and Hensley, K. (2000) Arch. Biochem. Biophys., 376, 1–13.PubMedCrossRefGoogle Scholar
  74. 74.
    Baeuerle, P., and Baltimore, D. (1996) Cell, 87, 13–20.PubMedCrossRefGoogle Scholar
  75. 75.
    Hirota, K., Murata, M., Sachi, Y., Nakamura, H., Takeuchi, J., Mori, K., and Yodoi, J. (1999) J. Biol. Chem., 274, 27891–27897.PubMedCrossRefGoogle Scholar
  76. 76.
    Mitomo, K., Nakayama, K., Fujimoto, K., Sun, X., Seki, S., and Yamamoto, K. (1994) Gene, 145, 197–203.PubMedCrossRefGoogle Scholar
  77. 77.
    Rao, G. N., Katki, K. A., Madamanchi, N. R., Wu, Y., and Birrer, N. J. (1999) J. Biol. Chem., 274, 6003–6010.PubMedCrossRefGoogle Scholar
  78. 78.
    Xanthoudakis, S., Miao, G., Wang, F., Pan, Y. C., and Curran, T. (1992) EMBO J., 11, 3323–3335.PubMedGoogle Scholar
  79. 79.
    Arrigo, A. P. (1999) Free Rad. Biol. Med., 27, 936–944.PubMedCrossRefGoogle Scholar
  80. 80.
    Buzek, J., Latonen, L., Kurki, S., Pelponen, K., and Laiho, M. (2002) Nucleic Acids Res., 30, 2340–2348.PubMedCrossRefGoogle Scholar
  81. 81.
    Allen, R. G., and Balin, A. K. (1989) Free Rad. Biol. Med., 6, 631–661.PubMedCrossRefGoogle Scholar
  82. 82.
    Smith, J., Ladi, E., Mayer-Proschel, M., and Noble, M. (2000) Proc. Natl. Acad. Sci. USA, 97, 10032–10037.PubMedCrossRefGoogle Scholar
  83. 83.
    Aw, T. Y. (2003) News Physiol. Sci., 18, 201–204.PubMedGoogle Scholar
  84. 84.
    Noble, M., Smith, J., Power, J., and Mayer-Proschel, M. (2003) Ann. N. Y. Acad. Sci., 991, 251–271.PubMedCrossRefGoogle Scholar
  85. 85.
    Shackelford, R. E., Kaufmann, W. K., and Paules, R. S. (2000) Free Rad. Biol. Med., 28, 1387–1404.PubMedCrossRefGoogle Scholar
  86. 86.
    Menon, S. G., Sarsour, E. H., Spitz, D. R., Higashikubo, R., Sturm, M., Zhang, H., and Goswami, P. C. (2003) Cancer Res., 63, 2109–2117.PubMedGoogle Scholar
  87. 87.
    Havens, C. G., Ho, A., Yoshioka, N., and Dowdy, S. F. (2006) Mol. Cell Biol., 26, 4701–4711.PubMedCrossRefGoogle Scholar
  88. 88.
    Sel’kov, E. E. (1970) Biofizika, 15, 1065–1073.PubMedGoogle Scholar
  89. 89.
    Lioyda, Lemara, K. M., Salgadoa, L. E. J., Goulda, T. M., and Murraya, D. B. (2003) FEMS Yeast Res., 3, 333–339.CrossRefGoogle Scholar
  90. 90.
    Hutter, D. E., Till, B. G., and Greene, J. J. (1997) Exp. Cell Res., 232, 435–438.PubMedCrossRefGoogle Scholar
  91. 91.
    Hoffman, A., Spetner, L. M., and Burke, M. (2002) Carcinogenesis, 23, 1961.PubMedCrossRefGoogle Scholar
  92. 92.
    Murakami, A., Takahashi, D., Kinoshita, T., Koshimizu, K., Kim, H. W., Yoshihiro, A., Nakamura, Y., Jiwajinda, S., Terao, J., and Ohigashi, H. (2002) Carcinogenesis, 23, 795–802.PubMedCrossRefGoogle Scholar
  93. 93.
    Menon, S. G., Coleman, M. C., Walsh, S. A., Spitz, D. R., and Goswami, P. C. (2005) Antiox. Redox. Signal., 7, 711–718.CrossRefGoogle Scholar
  94. 94.
    Gulbins, E., Jekle, A., Ferlinz, K., Grassme, H., and Lang, F. (2000) Am. J. Physiol. Renal. Physiol., 279, 605–615.Google Scholar
  95. 95.
    Ghibelli, L., Fanelli, C., Rotilio, G., Lafavia, E., Coppola, S., Colussi, C., Civitareale, P., and Ciriolo, M. R. (1998) FASEB J., 12, 479–486.PubMedGoogle Scholar
  96. 96.
    Kwon, Y. W., Masutani, H., Nakamura, H., Ishii, Y., and Yodoi, J. (2003) J. Biol. Chem., 384, 991–996.CrossRefGoogle Scholar
  97. 97.
    Migliaccio, E., Giorgio, V., and Mele, S. (1999) Nature, 402, 309–313.PubMedCrossRefGoogle Scholar
  98. 98.
    Trinei, M., Giorgio, M., Cicalese, A., et al. (2002) Oncogene, 21, 3872–3878.PubMedCrossRefGoogle Scholar
  99. 99.
    Giorgio, M., Migliaccio, E., Orsini, F., et al. (2005) Cell, 122, 221–233.PubMedCrossRefGoogle Scholar
  100. 100.
    Nemoto, S., and Finkel, T. (2002) Science, 295, 2450–2452.PubMedCrossRefGoogle Scholar
  101. 101.
    Skulachev, V. P., and Longo, V. D. (2005) Ann. N. Y. Acad. Sci., 1057, 145–164.PubMedCrossRefGoogle Scholar
  102. 102.
    He, Y. Y., Huang, J. L., Ramirez, D. C., and Chignell, C. F. (2003) J. Biol. Chem., 278, 8058–8064.PubMedCrossRefGoogle Scholar
  103. 103.
    Grierson, A. W., Nicholson, R., Talbot, P., Webster, A., and Kemp, G. (1994) J. Gen. Virol., 75, 2761–2764.PubMedGoogle Scholar
  104. 104.
    Davis, D. A., Newcomb, F. M., Starke, D. W., Ott, D. E., Mieyal, J. J., and Yarchoan, R. (1997) J. Biol. Chem., 272, 25935–25940.PubMedCrossRefGoogle Scholar
  105. 105.
    Hammond, C. L., Madejczyk, M. S., and Ballatori, N. (2004) Toxicol. Appl. Pharmacol., 195, 12–22.PubMedCrossRefGoogle Scholar
  106. 106.
    Macho, A., Hirsch, T., Marzo, I., Marchetti, P., Dallaporta, B., Susi, S. A., Zamzami, N., and Kroemer, G. (1997) J. Immunol., 158, 4612–4619.PubMedGoogle Scholar
  107. 107.
    Sandstrom, P. A., Mannie, M. D., and Buttke, T. M. (1995) J. Leukoc. Biol., 55, 221–226.Google Scholar
  108. 108.
    Voehringer, D. W. (1999) Free Rad. Biol. Med., 27, 945–950.PubMedCrossRefGoogle Scholar
  109. 109.
    Mirkovic, N., Voehringer, D. W., Story, M. D., McConkey, D. J., McDonnel, T. J., and Meyn, R. E. (1997) Oncogene, 15, 1461–1470.PubMedCrossRefGoogle Scholar
  110. 110.
    Meredith, M. J., Cusick, C. L., Soltaninassab, S., Sekhar, K. S., Lu, S., and Freeman, M. L. (1998) Biochem. Biophys. Res. Commun., 248, 458–463.PubMedCrossRefGoogle Scholar
  111. 111.
    Voehringer, D. W., McConkey, D. J., McDonnel, T. J., Brisbay, S., and Meyn, R. E. (1998) Proc. Natl. Acad. Sci. USA, 95, 2960.CrossRefGoogle Scholar
  112. 112.
    Hirota, K., Matsui, M., Iwata, S., Nishiyama, A., Mori, K., and Yodoi, J. (1997) Proc. Natl. Acad. Sci. USA, 94, 3633–3638.PubMedCrossRefGoogle Scholar
  113. 113.
    Andoh, T., Chock, P. B., and Chiueh, C. C. (2002) J. Biol. Chem., 277, 9655–9660.PubMedCrossRefGoogle Scholar
  114. 114.
    Chance, B., Sies, H., and Boveris, A. (1979) Physiol. Rev., 59, 527–605.PubMedGoogle Scholar
  115. 115.
    Fernandes, R. S., and Cotter, T. G. (1994) Biochem. Pharmacol., 48, 675–681.PubMedCrossRefGoogle Scholar
  116. 116.
    Nobel, C. S. I., Burgess, D. H., Zhivotovsky, B., Burkitt, M. J., Orrenius, S., and Slater, A. F. G. (1997) Chem. Res. Toxicol., 10, 636–643.PubMedCrossRefGoogle Scholar
  117. 117.
    Hentze, H., Kunstle, G., Volbracht, C., Ertel, W., and Wendel, A. (1999) Hepatology, 30, 177–185.PubMedCrossRefGoogle Scholar
  118. 118.
    Hentze, H., Schmitz, I., Latta, M., Krueger, A., Krammer, P. H., and Wendel, A. (2002) J. Biol. Chem., 277, 5588–4595.PubMedCrossRefGoogle Scholar
  119. 119.
    Moriarty-Craige, S. E., and Jones, D. P. (2004) Annu. Rev. Nutr., 24, 481–509.PubMedCrossRefGoogle Scholar
  120. 120.
    Pompella, A., Visvikis, A., Paolicchi, A., de Tata, V., and Casini, A. (2003) Biochem. Pharmacol., 66, 1499–1503.PubMedCrossRefGoogle Scholar
  121. 121.
    Zheng, M., and Storz, G. (2000) Biochem. Pharmacol., 59, 1–6.PubMedCrossRefGoogle Scholar
  122. 122.
    Pomposiello, P. J., and Demple, B. (2001) Trends Biotechnol., 19, 109–114.PubMedCrossRefGoogle Scholar
  123. 123.
    Demple, B., Ding, H., and Jorgensen, M. (2002) Meth. Enzymol., 348, 355–364.PubMedGoogle Scholar
  124. 124.
    Paget, M. S. B., and Buttner, M. J. (2003) Annu. Rev. Genet., 37, 91–121.PubMedCrossRefGoogle Scholar
  125. 125.
    Delaunay, A., Isnard, A. D., and Toledano, M. B. (2000) EMBO J., 19, 5157–5166.PubMedCrossRefGoogle Scholar
  126. 126.
    Delaunay, A., Pflieger, D., and Barrault, M. B. (2002) Cell, 111, 471–481.PubMedCrossRefGoogle Scholar
  127. 127.
    Kuge, S., Toda, T., Iizuka, N., and Nomota, A. (1998) Genes Cells, 3, 521–532.PubMedCrossRefGoogle Scholar
  128. 128.
    Zheng, M., Wang, X., Templeton, L. J., Smulski, D. R., LaRossa, R. A., and Storz, G. (2001) J. Bacteriol., 183, 4562–4570.PubMedCrossRefGoogle Scholar
  129. 129.
    Zheng, M., Aslund, F., and Storz, G. (1998) Science, 279, 1718–1721.PubMedCrossRefGoogle Scholar
  130. 130.
    Choi, S. J., Kim, H. J., Mukhopadhyay, P., Cho, S., Woo, J. R., Storz, G., and Ryu, S. E. (2001) Cell, 105, 103–113.PubMedCrossRefGoogle Scholar
  131. 131.
    Aslund, F., Zheng, M., Beckwith, J., and Storz, G. (1999) Proc. Natl. Acad. Sci. USA, 96, 6161–6165.PubMedCrossRefGoogle Scholar
  132. 132.
    Smirnova, G. V., Muzyka, N. G., Glukhovchenko, M. N., and Oktyabrsky, O. N. (2000) Free Rad. Biol. Med., 28, 1009–1016.PubMedCrossRefGoogle Scholar
  133. 133.
    Kim, S. O., Merchant, K., Nudelman, R., Beyer, W. F., Jr., and Keng, T. (2002) Cell, 109, 383–396.PubMedCrossRefGoogle Scholar
  134. 134.
    Hausladen, A., Privalle, C. T., Keng, T., DeAngelo, J., and Stamler, J. S. (1996) Cell, 86, 719–729.PubMedCrossRefGoogle Scholar
  135. 135.
    Hidalgo, E., and Demple, B. (1996) in Regulation of Gene Expression in Escherichia coli (Lin, E. C. C., and Lynch, A. S., eds.) R. G. Landes Company, Austin, pp. 435–452.Google Scholar
  136. 136.
    Hidalgo, E., and Demple, B. (1994) EMBO J., 13, 138–146.PubMedGoogle Scholar
  137. 137.
    Ding, H., Hidalgo, E., and Demple, B. (1996) J. Biol. Chem., 271, 33173–33175.PubMedCrossRefGoogle Scholar
  138. 138.
    Ding, H., and Demple, B. (1997) Proc. Natl. Acad. Sci. USA, 94, 8445–8449.PubMedCrossRefGoogle Scholar
  139. 139.
    Outten, C. E., Outten, F. W., and O’Halloran, T. V. (1999) J. Biol. Chem., 274, 37517–37524.PubMedCrossRefGoogle Scholar
  140. 140.
    Chander, M., and Demple, B. (2004) J. Biol. Chem., 279, 41603–41610.PubMedCrossRefGoogle Scholar
  141. 141.
    Newberry, K. J., and Brennan, R. G. (2004) J. Biol. Chem., 279, 20356–20362.PubMedCrossRefGoogle Scholar
  142. 142.
    Liochev, S. I., and Fridovich, I. (1992) Proc. Natl. Acad. Sci. USA, 89, 5892–5896.PubMedCrossRefGoogle Scholar
  143. 143.
    Kobayashi, K., and Tagawa, S. (1999) FEBS Lett., 451, 227–230.PubMedCrossRefGoogle Scholar
  144. 144.
    Koo, M. S., Lee, J. H., Rah, S. Y., Yeo, W. S., Lee, J. W., Lee, K. L., Koh, Y. S., Kang, S. O., and Roe, H. R. (2003) EMBO J., 22, 2614–2622.PubMedCrossRefGoogle Scholar
  145. 145.
    Nunoshiba, T., DeRojas-Walker, T., Tannenbaum, S. R., and Demple, B. (1995) Infect. Immun., 63, 794–798.PubMedGoogle Scholar
  146. 146.
    Ding, H., and Demple, B. (2000) J. Biol. Chem., 97, 33173–33175.Google Scholar
  147. 147.
    Pomposiello, P. J., and Demple, B. (2002) Adv. Microb. Physiol., 46, 319–341.PubMedCrossRefGoogle Scholar
  148. 148.
    Vlamis-Gardikas, A., Potamitou, A., Zarivach, R., Hochman, A., and Holmgren, A. (2002) J. Biol. Chem., 277, 10861–10868.PubMedCrossRefGoogle Scholar
  149. 149.
    Kumar, J., Tabor, S., and Richardson, C. C. (2004) Proc. Natl. Acad. Sci. USA, 101, 3759–3764.PubMedCrossRefGoogle Scholar
  150. 150.
    Owens, R. A., and Hartman, P. E. (1986) J. Bacteriol., 168, 109–114.PubMedGoogle Scholar
  151. 151.
    Suzuki, H., Kumagai, H., and Tochikura, T. (1987) J. Bacteriol., 169, 3926–3931.PubMedGoogle Scholar
  152. 152.
    Smirnova, G. V., Krasnykh, T. A., and Oktyabrsky, O. N. (2001) Biochemistry (Moscow), 66, 973–978.CrossRefGoogle Scholar
  153. 153.
    Smirnova, G. V., and Oktyabrsky, O. N. (2005) Biochemistry (Moscow), 70, 1199–1211.CrossRefGoogle Scholar
  154. 154.
    Ritz, D., and Beckwith, J. (2001) Annu. Rev. Microbiol., 55, 21–48.PubMedCrossRefGoogle Scholar
  155. 155.
    Cross, J. V., and Templeton, D. (2004) J. Cell. Biochem., 93, 104–111.PubMedCrossRefGoogle Scholar

Copyright information

© Pleiades Publishing, Ltd. 2007

Authors and Affiliations

  1. 1.Institute of Ecology and Genetics of MicroorganismsUrals Division of the Russian Academy of SciencesPerm’Russia

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