Biochemistry (Moscow)

, Volume 71, Issue 10, pp 1051–1059

Molecular interactions of acute phase serum amyloid A: Possible involvement in carcinogenesis

Review

DOI: 10.1134/S0006297906100014

Cite this article as:
Vlasova, M.A. & Moshkovskii, S.A. Biochemistry (Moscow) (2006) 71: 1051. doi:10.1134/S0006297906100014

Abstract

Acute phase serum amyloid A (A-SAA) is a well-known marker of inflammation. The present review summarizes data on the regulation of A-SAA expression, signaling pathways which it is involved in, its effects, and possible influences on progression of malignant tumors.

Key words

inflammation malignant tumor serum amyloid A NFκB matrix metalloproteinase 

Abbreviations

A-SAA

acute phase serum amyloid A

C/EBP

CCAAT enhancer binding protein

HDL

high density lipoprotein

IL

interleukin

LPS

lipopolysaccharide

MMP

matrix metalloproteinase

NFkB

nuclear factor kB

SAF1

SAA-activating factor

TIMP

tissue inhibitor of matrix metalloproteinase

TNF

tumor necrosis factor

Copyright information

© Pleiades Publishing, Inc. 2006

Authors and Affiliations

  1. 1.Orekhovich Institute of Biomedical ChemistryRussian Academy of Medical SciencesMoscowRussia

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