Ubiquitin-protein ligase parkin and its role in the development of Parkinson’s disease
- Cite this article as:
- Buneeva, O.A. & Medvedev, A.E. Biochemistry (Moscow) (2006) 71: 851. doi:10.1134/S0006297906080050
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Parkin is a protein encoded by the corresponding parkin gene. It exhibits ubiquitin-protein ligase activity. In this review, we analyze domain structure, substrate specificity, subcellular localization of parkin, and regulation of its activity. Then we discuss data on the effects of various mutations in the parkin gene on structure and functions of this protein and results obtained with parkin knock-out animals. Better understanding of parkin biochemistry, its compartmentalization, functions, and altered functions would help the development of new approaches for the treatment of both inherited and sporadic cases of Parkinson’s disease.
Key wordsparkin Parkinson’s disease proteasome ubiquitination ubiquitin-protein ligase mitochondria
cell division control-related protein
C-terminus Hsp 70-interacting protein
- Hsp 70
heat shock protein 70 kD
parkin-associated endothelial-like receptor
really interesting gene
ubiquitin carboxy-terminal hydrolase L1
unique parkin domain.