Biochemistry (Moscow)

, Volume 71, Issue 8, pp 851–860

Ubiquitin-protein ligase parkin and its role in the development of Parkinson’s disease

Review

Abstract

Parkin is a protein encoded by the corresponding parkin gene. It exhibits ubiquitin-protein ligase activity. In this review, we analyze domain structure, substrate specificity, subcellular localization of parkin, and regulation of its activity. Then we discuss data on the effects of various mutations in the parkin gene on structure and functions of this protein and results obtained with parkin knock-out animals. Better understanding of parkin biochemistry, its compartmentalization, functions, and altered functions would help the development of new approaches for the treatment of both inherited and sporadic cases of Parkinson’s disease.

Key words

parkin Parkinson’s disease proteasome ubiquitination ubiquitin-protein ligase mitochondria 

Abbreviations

CDCrel-1

cell division control-related protein

CHIP

C-terminus Hsp 70-interacting protein

EPR

endoplasmic reticulum

Hsp 70

heat shock protein 70 kD

IBR

inbetween RING-site

MAO

monoamine oxidase

Pael-R

parkin-associated endothelial-like receptor

PD

Parkinson’s disease

RING

really interesting gene

UBL-domain

ubiquitin-like domain

UCL-L1

ubiquitin carboxy-terminal hydrolase L1

UPD-domain

unique parkin domain.

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References

  1. 1.
    Lang, A. E., and Lozano, A. M. (1998) N. Engl. J. Med., 339, 1044–1053.PubMedGoogle Scholar
  2. 2.
    Lang, A. E., and Lozano, A. M. (1998) N. Engl. J. Med., 339, 1130–1143.PubMedGoogle Scholar
  3. 3.
    Forno, L. S. (1996) J. Neuropathol. Exp. Neurol., 55, 259–272.PubMedGoogle Scholar
  4. 4.
    Giasson, B. I., and Lee, V. M.-Y. (2001) Neuron, 31, 885–888.PubMedGoogle Scholar
  5. 5.
    Gasser, T. (2001) J. Neurol., 248, 833–840.PubMedGoogle Scholar
  6. 6.
    Dawson, T., Mandir, A., and Lee, M. (2002) Neuron, 35, 219–222.PubMedGoogle Scholar
  7. 7.
    Dawson, T. M., and Dawson, V. L. (2003) J. Clin. Invest., 111, 145–151.PubMedGoogle Scholar
  8. 8.
    Goedert, M. (2001) Nat. Rev. Neurosci., 2, 492–501.PubMedGoogle Scholar
  9. 9.
    Braak, H., Braak, E., Yilmazer, D., Schultz, C., de Vos, R. A., and Jansen, E. N. (1995) J. Neural Transm., 46(Suppl.), 15–31.Google Scholar
  10. 10.
    Sherman, M. Y., and Goldberg, A. L. (2001) Neuron, 29, 15–32.PubMedGoogle Scholar
  11. 11.
    DeMartino, G. N., and Slauter, C. A. (1999) J. Biol. Chem., 274, 22123–22126.PubMedGoogle Scholar
  12. 12.
    Betarbet, R., Sherer, T. B., and Greenamyre, J. T. (2005) Exp. Neurol., 191, S17–S27.PubMedGoogle Scholar
  13. 13.
    Rotanova, T. V. (2001) Vopr. Med. Khim., 47, 3–19.PubMedGoogle Scholar
  14. 14.
    Wojcik, C., and DeMartino, G. N. (2003) Int. J. Biochem. Cell. Biol., 35, 579–589.PubMedGoogle Scholar
  15. 15.
    Coux, O., Tanaka, K., and Goldberg, A. L. (1996) Annu. Rev. Biochem., 65, 801–847.PubMedGoogle Scholar
  16. 16.
    Baumeister, W., Walz, J., Zuhl, F., and Seemuller, E. (1998) Cell, 92, 367–380.PubMedGoogle Scholar
  17. 17.
    Ciechanover, A. (1994) Biol. Chem. Hoppe-Seyler, 375, 565–581.PubMedGoogle Scholar
  18. 18.
    Chung, K. K., Dawson, V. L., and Dawson, T. M. (2001) Trends Neurosci., 24(Suppl.), S7–S14.PubMedGoogle Scholar
  19. 19.
    Weissman, A. M. (2001) Nat. Rev. Mol. Cell Biol., 2, 169–178.PubMedGoogle Scholar
  20. 20.
    Hu, B. R., Martone, M. E., Jones, Y. Z., and Liu, C. L. (2000) J. Neurosci., 20, 3191–3199.PubMedGoogle Scholar
  21. 21.
    Adamo, A. M., Pasquini, L. A., Moreno, M. B., Oteiza, P. I., Soto, E. F., and Pasquini, J. M. (1999) J. Neurosci. Res., 55, 523–531.PubMedGoogle Scholar
  22. 22.
    Mangani, M., Serafini, G., Antonelli, A., Malatesta, M., and Gazzanelli, G. (1991) J. Biol. Chem., 266, 21018–21024.Google Scholar
  23. 23.
    Zhuang, Z., and McCauley, R. (1989) J. Biol. Chem., 264, 14594–14596.Google Scholar
  24. 24.
    Zhuang, Z., Marks, B., and McCauley, R. (1992) J. Biol. Chem., 267, 591–596.PubMedGoogle Scholar
  25. 25.
    Mandel, S., Weinreb, O., Amit, T., and Youdim, M. B. (2005) Brain Res. Rev., 48, 379–387.PubMedGoogle Scholar
  26. 26.
    Youdim, M. B., Maruyama, W., and Naomi, M. (2005) Drugs Today (Barc), 41, 369–391.Google Scholar
  27. 27.
    Riederer, P., Lachenmayer, L., and Laux, G. (2004) Curr. Med. Chem., 11, 2033–2043.PubMedGoogle Scholar
  28. 28.
    Birks, J., and Flicker, L. (2003) Cochrane Database Syst. Rev., CD000442.Google Scholar
  29. 29.
    Buneeva, O. A., Medvedeva, M. V., and Medvedev, A. E. (1999) Neurobiology, 7, 257–261.PubMedGoogle Scholar
  30. 30.
    Medvedev, A. E., and Gorkin, V. Z. (1994) Int. J. Devel. Neurosci., 12, 151–155.Google Scholar
  31. 31.
    Medvedev, A. E., Kirkel, A., Kamyshanskaya, N., and Gorkin, V. (1993) Int. J. Biochem., 25, 1791–1799.PubMedGoogle Scholar
  32. 32.
    Medvedev, A. E., and Tipton, K. F. (1997) Vopr. Med. Khim., 43, 471–481.PubMedGoogle Scholar
  33. 33.
    Shimura, H., Hattori, N., Kubo, S., Mizuno, Y., Asakawa, S., Minoshima, S., Shimizu, N., Iwai, K., Chiba, T., Tanaka, K., and Suzuki, T. (2000) Nat. Genet., 25, 302–305.PubMedGoogle Scholar
  34. 34.
    Bonifati, V. (2005) Minerva Med., 96, 175–186.PubMedGoogle Scholar
  35. 35.
    Dawson, T. M., and Dawson, V. L. (2003) J. Clin. Invest., 111, 145–151.PubMedGoogle Scholar
  36. 36.
    Klein, C., Pramstaller, P. P., Kis, B., Page, C. C., Kann, M., Leung, J., Woodward, H., Castellan, C. C., Schrerer, M., Vieregge, P., Breakfield, X. O., Kramer, P. L., and Ozelius, L. J. (2000) Ann. Neurol., 48, 65–71.PubMedGoogle Scholar
  37. 37.
    Ramsden, D. B., Parsons, R. B., Ho, S. I., and Waring, R. H. (2001) J. Clin. Pathol. Mol. Pathol., 54, 369–380.Google Scholar
  38. 38.
    Cookson, M. R. (2005) Ann. Rev. Biochem., 74, 29–52.PubMedGoogle Scholar
  39. 39.
    Gasser, T., Muller-Myhsok, B., Wszolek, Z. K., Oehlmann, R., Calne, D. B., Bonifati, V., Bereznai, B., Fabrizio, E., Vieregge, P., and Horstmann, R. D. (1998) Natl. Genet., 18, 262–265.Google Scholar
  40. 40.
    Funayama, M., Hasegawa, K., Kowa, H., Saito, M., Tsuji, S., and Obata, F. (2002) Ann. Neurol., 51, 296–301.PubMedGoogle Scholar
  41. 41.
    Wszolek, Z. K., Pfeiffer, R. F., Tsuboi, Y., Uitti, R. J., McComb, R. D., Stoessl, A. J., Strongosky, A. J., Zimprich, A., Muller-Myhsok, B., Farrer, M. J., Gasser, T., Calne, D. B., and Dickson, D. W. (2004) Neurology, 62, 1619–1622.PubMedGoogle Scholar
  42. 42.
    Canet-Aviles, R. M., Wilson, M. A., Miller, D. W., Ahmad, R., McLendon, C., Bandyopadhyay, S., Baptista, M. J., Ringe, D., Prtsko, G. A., and Cookson, M. R. (2004) Proc. Natl. Acad. Sci. USA, 101, 9103–9108.PubMedGoogle Scholar
  43. 43.
    Yokota, T., Sugawara, K., Ito, K., Takahashi, R., Ariga, H., and Mizusawa, H. (2003) Biochem. Biophys. Res. Commun., 312, 1342–1348.PubMedGoogle Scholar
  44. 44.
    Valente, E. M., Abou-Sleiman, P. M., Caputo, V., Muqit, M. M., Harvey, K., Gispet, S., Ali, Z., DelTurco, D., Bentivoglio, A. R., Healy, D. G., Albanese, A., Nussbaum, R., Gonzalez-Maldonado, R., Deller, T., Salvi, S., Cortelli, P., Gilks, W. P., Latchman, D. S., Harvey, R. J., Dallapiccola, B., Auburger, G., and Wood, N. W. (2004) Science, 304, 1158–1160.PubMedGoogle Scholar
  45. 45.
    Polymeropoulos, M. H., Goelbe, L. I., Johnson, W. G., Ide, S. E., di Iorio, G., Sanges, G., Stenroos, E. S., Pho, L. T., Schaffer, A. A., Lazzarini, A. M., Nussbaum, R. L., and Duvoisin, R. C. (1996) Science, 274, 1197–1199.PubMedGoogle Scholar
  46. 46.
    Kruger, R., Kuhn, W., Muller, T., Woitalla, D., Graeber, M., Kosel, S., Przuntek, H., Epplen, J. T., Schols, L., and Riess, O. (1998) Nat. Genet., 18, 106–108.PubMedGoogle Scholar
  47. 47.
    Zarranz, J. J., Alegre, J., Gomez-Esteban, J. C., Lezcano, E., Ros, R., Ampuero, I., Vidal, L., Hoenicka, J., Rodriguez, O., Atares, B., Llorens, V., Gomez Tortosa, E., del Ser, T., Munoz, D. G., and de Yebenes, J. G. (2004) Ann. Neurol., 55, 164–173.PubMedGoogle Scholar
  48. 48.
    Singleton, A. B., Farrer, M., Johnson, J., Singleton, A., Hague, S., Kachergus, J., Hulihan, M., Peuralinna, T., Dutra, A., Nussbaum, R., Lincoln, S., Crawley, A., Hanson, M., Maraganore, D., Adler, C., Cookson, M. R., Muenter, M., Baptista, M., Miller, D., Blancato, J., Hardy, J., and Gwinn-Hardy, K. (2003) Science, 302, 841.PubMedGoogle Scholar
  49. 49.
    Polymeropoulos, M. H., Lavedan, C., Leroy, E., Ide, S. E., Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R., Stenroos, E. S., Chandrasekharappa, S., Athanassiadou, A., Papapetropoulos, T., Johnson, A. M., Lazzarini, A. M., Duvoisin, R. S., di Iorio, G., Golbe, L. I., and Nussbaum, R. L. (1997) Science, 276, 2045–2047.PubMedGoogle Scholar
  50. 50.
    Clayton, D. F., and George, J. M. (1998) Trends Neurosci., 21, 249–254.PubMedGoogle Scholar
  51. 51.
    McNaught, K. S., Olanow, C. W., Halliwell, B., Isacson, O., and Jenner, P. (2001) Nat. Rev. Neurosci., 2, 589–594.PubMedGoogle Scholar
  52. 52.
    Ciechanover, A., and Brundin, P. (2003) Neuron, 40, 427–446.PubMedGoogle Scholar
  53. 53.
    Farrer, M., Chan, P., Chen, R., Tan, L., Lincoln, S., Hernandez, D., Forno, L., Gwinn-Hardy, K., Petrucelli, L., Hussey, J., Singleton, A., Tanner, C., Hardy, J., and Langston, J. W. (2001) Ann. Neurol., 50, 293–300.PubMedGoogle Scholar
  54. 54.
    Duda, J. E., Lee, V. M.-Y., and Trojanovski, J. Q. (2000) J. Neurosci. Res., 61, 121–127.PubMedGoogle Scholar
  55. 55.
    Mizuno, Y., Hattori, N., and Matsumine, H. (1998) J. Neurochem., 71, 893–902.PubMedGoogle Scholar
  56. 56.
    Kitada, T., Asakawa, S., Hattori, N., Matsumine, H., Yamamura, Y., Minoshima, S., Yokochi, M., Mizuno, Y., and Shimizu, N. (1998) Nature, 392, 605–608.PubMedGoogle Scholar
  57. 57.
    Kahle, P. J., and Haass, C. (2004) EMBO Rep., 5, 681–685.PubMedGoogle Scholar
  58. 58.
    Marin, I., and Ferrus, A. (2002) Mol. Biol. Evol., 19, 2039–2050.PubMedGoogle Scholar
  59. 59.
    Kahns, S., Kalai, M., Jakobsen, L. D., Clark, B. F. C., Vandenabeele, P., and Jensen, P. H. (2003) J. Biol. Chem., 78, 23376–23380.Google Scholar
  60. 60.
    Yamamoto, A., Friedlein, A., Imai, Y., Takahashi, R., Kalle, P.J., and Haass, C. (2005) J. Biol. Chem., 280, 3390–3399.PubMedGoogle Scholar
  61. 61.
    Shimura, H., Schlossmacher, M. G., Hattori, N., Frosch, M. P., Trockenbacher, A., Schneider, R., Muzino, Y., Kosik, K. S., and Selkoe, D. J. (2001) Science, 293, 263–269.PubMedGoogle Scholar
  62. 62.
    Upadhia, S. C., and Hegde, A. N. (2003) Trends Biochem. Sci., 28, 280–283.Google Scholar
  63. 63.
    Sacata, E., Yamaguchi, Y., Kurimoto, E., Kikuchi, J., Yokoyama, S., Yamada, S., Kawahara, H., Yokosawa, H., Hattori, N., Mizuno, Y., Tanaka, K., and Kato, K. (2003) EMBO Rep., 4, 301–306.Google Scholar
  64. 64.
    Imai, Y., Soda, M., and Takahashi, R. (2000) J. Biol. Chem., 275, 35661–35664.PubMedGoogle Scholar
  65. 65.
    Zhang, Y., Gao, J., Chung, K. K., Huang, H., Dawson, V. L., and Dawson, T. M. (2000) Proc. Natl. Acad. Sci. USA, 97, 13354–13359.PubMedGoogle Scholar
  66. 66.
    Beites, C. L., Xie, H., Bowser, R., and Trimble, W. S. (1999) Nat. Neurosci., 2, 434–439.PubMedGoogle Scholar
  67. 67.
    Imai, Y., Soda, M., Inoue, H., Hattori, N., Mizuno, Y., and Takahashi, R. (2001) Cell, 105, 891–902.PubMedGoogle Scholar
  68. 68.
    Murakami, T., Shoji, M., Imai, Y., Inoue, H., Kawarabayashi, T., Matsubara, E., Harigaya, Y., Sasaki, A., Takahashi, R., and Abe, K. (2004) Ann. Neurol., 55, 439–442.PubMedGoogle Scholar
  69. 69.
    Yang, Y., Nishimura, I., Imai, Y., Takahashi, R., and Lu, B. (2003) Neuron, 37, 911–924.PubMedGoogle Scholar
  70. 70.
    Chung, K. K., Zhang, Y., Lim, K. L., Tanaka, Y., Huang, H., Gao, J., Ross, C. A., Dawson, V. L., and Dawson, T. M. (2001) Nat. Med., 7, 1144–1150.PubMedGoogle Scholar
  71. 71.
    Engelender, S., Kaminsky, Z., Guo, X., Sharp, A. H., Amaravi, R. K., Kleiderlein, J. J., Margolis, R. L., Troncoso, J. C., Lanahan, A. A., Worley, P. F., Dawson, V. L., Dawson, T. M., and Ross, C. A. (1999) Nat. Genet., 22, 110–114.PubMedGoogle Scholar
  72. 72.
    Wakabayashi, K., Engelender, S., Yoshimoto, M., Tsuji, S., Ross, C. A., and Takahashi, H. (2000) Ann. Neurol., 47, 521–523.PubMedGoogle Scholar
  73. 73.
    Dawson, T. M. (2000) Cell, 101, 115–118.PubMedGoogle Scholar
  74. 74.
    Golbe, L. I., and Mouradian, M. M. (2004) Ann. Neurol., 55, 153–156.PubMedGoogle Scholar
  75. 75.
    Corti, O., Hampe, C., Koutnikova, H., Darios, F., Jacquier, S., Prigent, A., Robinson, J. C., Pradier, L., Ruberg, M., Mirande, M., Hirsch, E., Rooney, T., Fournier, A., and Brice, A. (2003) Hum. Mol. Genet., 12, 1427–1437.PubMedGoogle Scholar
  76. 76.
    Huynn, D. P., Scoles, D. R., Nguyen, D., and Pulst, S. M. (2003) Hum. Mol. Genet., 12, 2587–2597.Google Scholar
  77. 77.
    Staropoli, J. F., McDermott, C., Martinat, C., Schulman, B., Demirava, E., and Abelovich, A. (2003) Neuron, 37, 735–749.PubMedGoogle Scholar
  78. 78.
    Ren, Y., Zhao, J., and Feng, J. (2003) J. Neurosci., 23, 3316–3324.PubMedGoogle Scholar
  79. 79.
    Burke, D., Gasdaska, P., and Hartwell, L. (1989) Mol. Cell Biol., 9, 1049–1059.PubMedGoogle Scholar
  80. 80.
    Imai, Y., and Takahashi, R. (2004) Curr. Opin. Neurobiol., 14, 384–389.PubMedGoogle Scholar
  81. 81.
    Tsai, Y. C., Fishman, P. S., Thakor, N. V., and Oyler, G. A. (2003) J. Biol. Chem., 278, 22044–22055.PubMedGoogle Scholar
  82. 82.
    Imai, Y., Soda, M., Hatakeyama, S., Akagi, T., Hashikawa, T., Nakayama, K. I., and Takahashi, R. (2002) Mol. Cell, 10, 55–67.PubMedGoogle Scholar
  83. 83.
    Murata, S., Minami, Y., Minami, M., Chiba, T., and Tanaka, K. (2001) EMBO Rep., 2, 1133–1138.PubMedGoogle Scholar
  84. 84.
    Mouatt-Prigent, A., Muriel, M. P., Gu, W. J., El Hachimi, K. H., Lucking, C. B., Brice, A., and Hirsch, E. C. (2004) J. Neural Transm., 111, 1209–1218.PubMedGoogle Scholar
  85. 85.
    Shen, J., and Cookson, M. R. (2004) Neuron, 43, 301–304.PubMedGoogle Scholar
  86. 86.
    Beal, M. F. (2003) Ann. N. Y. Acad. Sci., 991, 120–131.PubMedGoogle Scholar
  87. 87.
    Jenner, P., and Olanow, C. W. (1998) Ann. Neurol., 44, S72–S84.PubMedGoogle Scholar
  88. 88.
    Betarbet, R., Sherer, T. B., MacKenzie, G., Garcia-Osuna, M., Panov, A. V., and Greenamyre, J. T. (2000) Nat. Neurosci., 3, 1301–1306.PubMedGoogle Scholar
  89. 89.
    Dauer, W., and Przedborski, S. (2003) Neuron, 39, 889–909.PubMedGoogle Scholar
  90. 90.
    Darios, F., Corti, O., Lucking, C. B., Hampe C., Muriel, M. P., Abbas, N., Gu, W. J., Hirsch, E. C., Rooney, T., Ruberg, M., and Brice, A. (2003) Hum. Mol. Genet., 12, 517–526.PubMedGoogle Scholar
  91. 91.
    Greene, J. C., Whitworth, A. J., Kuo, I., Andrews, L. A., Feany, M. B., and Pallanck, L. J. (2003) Proc. Natl. Acad. Sci. USA, 100, 4078–4083.PubMedGoogle Scholar
  92. 92.
    Pesah, Y., Pham, T., Burgess, H., Middlebrooks, B., Verstreken, P., Zhou, Y., Harding, M., Bellen, H., and Mardon, G. (2004) Development, 131, 2183–2194.PubMedGoogle Scholar
  93. 93.
    Goldberg, M. S., Fleming, S. M., Palacino, J. J., Cepeda, C., Lam, H. A., Bhatnagar, A., Meloni, E. G., Wu, N., Ackerson, L. C., Klapstein, G. P., Galjendiran, M., Roth, B. L., Chesselet, M. F., Maidment, N. T., Levine, M. S., and Shen, J. (2003) J. Biol. Chem., 278, 43628–43635.PubMedGoogle Scholar
  94. 94.
    Palacino, J. J., Sagi, D., Goldberg, M. S., Krauss, S., Motz, C., Wacker, M., Klose, J., and Shen, J. (2004) J. Biol. Chem., 279, 18614–18622.PubMedGoogle Scholar
  95. 95.
    Itier, J. M., Ibanes, P., Mena, M. A., Abbas, N., Cohen-Salmon, C., Bohme, G. A., Laville, M., Pratt, J., Corti, O., Pradier, L., Ret, G., Joubert, C., Periquet, M., Araujo, F., Negroni, J., Casarejos, M. J., Canals, S., Solano, R., Serrano, A., Gallego, E., Sanchez, M., Denefle, P., Benavides, J., Tremp, G., Rooney, T. A., Brice, A., and Garcia de Yebenes, J. (2003) Hum. Mol. Genet., 12, 2277–2291.PubMedGoogle Scholar
  96. 96.
    Von Coelln, R., Thomas, B., Savitt, J. M., Lim, K. L., Sasaki, M., Hess, E. J., Dawson, V. L., and Dawson, T. M. (2004) Proc. Natl. Acad. Sci. USA, 101, 10744–10749.Google Scholar
  97. 97.
    West, A. B., and Maidment, N. T. (2004) Hum. Genet., 114, 327–336.PubMedGoogle Scholar
  98. 98.
    Mata, I. F., Lockhart, P. J., and Farrer, M. J. (2004) Hum. Mol. Genet., 13(Suppl. 1), R127–R133.PubMedGoogle Scholar
  99. 99.
    Langston, J. W. (1996) Neurology, 47, S153–S160.PubMedGoogle Scholar
  100. 100.
    Tanaka, K., Suzuki, T., Hattori, N., and Mizuno, Y. (2004) Biochim. Biophys. Acta, 1695, 226–238.Google Scholar
  101. 101.
    Bonifati, V., Rizzu, P., van Baren, M. J., Schaap, O., Breedveld, G. J., Krieger, E., Dekker, M. C., Squitieri, F., Ibanez, P., Joosse, M., van Dongen, J. W., Vanacore, N., van Swieten, J. C., Brice, A., Meco, G., van Duijn, C. M., Oostra, B. A., and Heutink, P. (2003) Science, 299, 256–259.PubMedGoogle Scholar
  102. 102.
    Petrucelli, L., O’Farrell, C., Lockhart, P.J., Baptista, M., Kehoe, K., Vink, L., Choi, P., Wolozin, B., Farrer, M., Hardy, J., and Cookson, M. R. (2002) Neuron, 36, 1007–1019.PubMedGoogle Scholar
  103. 103.
    Hoglinger, G. U., Carrard, G., Michel, P. P., Medja, F., Lombes, A., Ruberg, M., Friguuet, B., and Hirsch, E. C. (2003) J. Neurochem., 86, 1297–1307.PubMedGoogle Scholar
  104. 104.
    McNaught, K. S. P., Perl, D. B., Brownell, A.-L., and Olanow, C. W. (2004) Ann. Neurol., 56, 149–162.PubMedGoogle Scholar
  105. 105.
    Sullivan, P. G., Dragicevic, N. B., Deng, J.-H., Bai, Y., Dimayuga, E., Ding, Q., Chen, Q., Bruce-Keller, A. J., and Keller, J. N. (2004) J. Biol. Chem., 279, 20699–20707.PubMedGoogle Scholar

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© Pleiades Publishing, Inc. 2006

Authors and Affiliations

  1. 1.Institute of Biomedical ChemistryRussian Academy of Medical SciencesMoscowRussia

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