Biochemistry (Moscow)

, Volume 71, Issue 8, pp 851–860

Ubiquitin-protein ligase parkin and its role in the development of Parkinson’s disease



Parkin is a protein encoded by the corresponding parkin gene. It exhibits ubiquitin-protein ligase activity. In this review, we analyze domain structure, substrate specificity, subcellular localization of parkin, and regulation of its activity. Then we discuss data on the effects of various mutations in the parkin gene on structure and functions of this protein and results obtained with parkin knock-out animals. Better understanding of parkin biochemistry, its compartmentalization, functions, and altered functions would help the development of new approaches for the treatment of both inherited and sporadic cases of Parkinson’s disease.

Key words

parkin Parkinson’s disease proteasome ubiquitination ubiquitin-protein ligase mitochondria 



cell division control-related protein


C-terminus Hsp 70-interacting protein


endoplasmic reticulum

Hsp 70

heat shock protein 70 kD


inbetween RING-site


monoamine oxidase


parkin-associated endothelial-like receptor


Parkinson’s disease


really interesting gene


ubiquitin-like domain


ubiquitin carboxy-terminal hydrolase L1


unique parkin domain.


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© Pleiades Publishing, Inc. 2006

Authors and Affiliations

  1. 1.Institute of Biomedical ChemistryRussian Academy of Medical SciencesMoscowRussia

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