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Applied Biochemistry and Microbiology

, Volume 54, Issue 6, pp 670–676 | Cite as

Highly Sensitive Immunochromatographic Detection of Antibiotic Ciprofloxacin in Milk

  • O. D. Hendrickson
  • E. A. Zvereva
  • I. A. Shanin
  • A. V. Zherdev
  • N. Tarannum
  • B. B. Dzantiev
Article
  • 13 Downloads

Abstract

In this study, highly sensitive immunochromatographic analyses (ICAs) of ciprofloxacin (CIP) are developed. CIP is an antibiotic of the fluoroquinolone group that is widely used in veterinary practice and contaminates agricultural products. The analyses are based on various techniques that introduce gold nanoparticles as markers. It has been shown that the schemes allow for the detection of CIP within 15 min with an instrumental detection limit of 10 pg/mL for both schemes and visual detection limits of 10 and 2 ng/mL for direct and indirect schemes, respectively. The developed systems have been tested to detect the antibiotic in milk samples. It has been shown that ICA can determine CIP in milk using a simple procedure of preliminary sample preparation with preservation of high analytical characteristics.

Keywords:

antibiotic ciprofloxacin immunochromatographic analysis food safety 

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Copyright information

© Pleiades Publishing, Inc. 2018

Authors and Affiliations

  • O. D. Hendrickson
    • 1
  • E. A. Zvereva
    • 1
  • I. A. Shanin
    • 2
    • 3
  • A. V. Zherdev
    • 1
  • N. Tarannum
    • 4
  • B. B. Dzantiev
    • 1
  1. 1.Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of SciencesMoscowRussia
  2. 2.Lomonosov Moscow State UniversityMoscowRussia
  3. 3.“Chema”MoscowRussia
  4. 4.Chaudhary Charan Singh UniversityMeerutIndia

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