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Applied Biochemistry and Microbiology

, Volume 51, Issue 9, pp 887–892 | Cite as

Production of taunit–antibiotic nanocomplexes and study of their antifungal activity relative to Aspergillus niger and Candida albicans

  • A. V. Timofeeva
  • M. V. Ilyina
  • E. A. Stepashkina
  • L. A. Baratova
  • G. S. Katrukha
Technology of Biopreparations

Abstract

Nanocomplexes based on a modern Taunit nanosorbent with polyene antibiotics (amphotericin B, nystatin A1, and natamycin) widely used in medical practice were obtained for the first time; their antifungal activity was studied. It was demonstrated that the Taunit–nystatin A1 complex is active as compared to Aspergillus niger, while the Taunit–natamycin complex is active as compared to Aspergillus niger and Candida albicans. The Taunit–amphotericin B nanocomplex is not active relative to the studied test organisms (A. niger and C. albicans). Possible mechanisms of the action of the obtained complexes are discussed.

Keywords

antimycotics antifungal activity Taunit–antibiotic type complexes Taunit multilayer carbon nanotubes polyene antibiotics 

Abbreviations

DMSO

dimethyl sulfoxide

CFU

colony-forming unit

MCNT

multilayer carbon nanotubes

MRSA

meticillinresistant Staphylococcus aureus

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Copyright information

© Pleiades Publishing, Inc. 2015

Authors and Affiliations

  • A. V. Timofeeva
    • 1
  • M. V. Ilyina
    • 2
  • E. A. Stepashkina
    • 3
  • L. A. Baratova
    • 1
  • G. S. Katrukha
    • 3
  1. 1.Belozersky Research Institute of Physico-Chemical BiologyMoscow State UniversityMoscowRussia
  2. 2.Mendeleyev University of Chemical Technology of RussiaMoscowRussia
  3. 3.Gause Institute of New AntibioticsRussian Academy of Medical SciencesMoscowRussia

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