Telomerase inhibitors as novel antitumor drugs

  • A. I. Glukhov
  • L. V. Svinareva
  • S. E. Severin
  • V. I. Shvets
Article

DOI: 10.1134/S0003683811070039

Cite this article as:
Glukhov, A.I., Svinareva, L.V., Severin, S.E. et al. Appl Biochem Microbiol (2011) 47: 655. doi:10.1134/S0003683811070039

Abstract

Telomerase activity is detected in most types of human tumors, but it is almost undetectable in normal somatic cells; therefore, telomerase is a promising therapeutic target. The present review describes various approaches to telomerase inhibition, namely, antisense therapy, RNA interference, and the use of ribozymes and agents interacting with the telomeric G-quadruplex. The use of these compounds in clinical research is analyzed in the review.

Keywords

antisense therapy immortalization G-quadruplex ribozyme RNA interference telomerase activity 

Abbreviations

2-5A

2′,5′-tetraadenylate

AZT

azidothymidine (3′-azido-2′,3′-dideoxythymidine)

ddG

dideoxyguanosine

ddGTP

dideoxyguanosine triphosphate

dsRNA

double stranded RNA

EGCG

epigallocatechin gallate

IC50

inhibitor concentration at which the TA decreases twofold

hTERT

the catalytic subunit of human telomerase

hTR

the RNA component of human telomerase

GRN163

N3′-P5′-thiophosphoramidate (13-nucleotide)

NP

oligonucleotides-phosphoramidate oligonucleotides

NPS

oligonucleotides-N3′-P5′-thiophosphoramidates

ODN

DNA oligonucleotides

ORN

RNA oligonucleotides

PNA

peptidonucleic acids

PS

phosphorothioate

RISC

RNA-protein complexes

siRNA

small interfering RNAs

TA

telomerase activity

TMO (telomere mimic oligonucleotides)

oligonucleotides consisting of telomeric repeats

TMPyP4

tetra-(N-methyl-4-pyridyl)-porphine

TRAP

telomerase activity assay procedure

Copyright information

© Pleiades Publishing, Ltd. 2011

Authors and Affiliations

  • A. I. Glukhov
    • 1
    • 2
  • L. V. Svinareva
    • 2
    • 3
  • S. E. Severin
    • 1
    • 2
  • V. I. Shvets
    • 3
  1. 1.Sechenov Medical AcademyMoscowRussia
  2. 2.Moscow Research Institute of Medical EcologyMoscowRussia
  3. 3.Lomonosov Moscow State Academy of Fine Chemical TechnologyMoscowRussia

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