Applied Biochemistry and Microbiology

, Volume 46, Issue 3, pp 267–273

Sulfated polysaccharides and their anticoagulant activity: A review


DOI: 10.1134/S000368381003004X

Cite this article as:
Mestechkina, N.M. & Shcherbukhin, V.D. Appl Biochem Microbiol (2010) 46: 267. doi:10.1134/S000368381003004X


Published data on the sulfated polysaccharides of various origins that display an anticoagulant activity are summarized and analyzed. The methods used for producing semisynthetic derivatives are considered. A key role of the polysaccharide structure in the mechanisms of specific interaction with various blood plasma proteinases is discussed. The effects of the content and location of sulfate groups in polysaccharides and their molecular weight on the degree of the studied activity are assessed.

Copyright information

© Pleiades Publishing, Ltd. 2010

Authors and Affiliations

  1. 1.Bach Institute of BiochemistryRussian Academy of SciencesMoscowRussia

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