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Applied Biochemistry and Microbiology

, Volume 42, Issue 6, pp 631–635 | Cite as

Preparation of biodegradable porous films for use as wound coverings

  • N. R. Kil’deeva
  • G. A. Vikhoreva
  • L. S. Gal’braikh
  • A. V. Mironov
  • G. A. Bonartseva
  • P. A. Perminov
  • A. N. Romashova
Article

Abstract

We studied the preparation of polymeric films formed from solutions of poly-3-hydroxybutyrate and poly-ε-caprolactone in chloroform and methylene chloride. A morphological study of film chips (electron microscopy) showed that solvent evaporation results in the formation of a heterogeneous structure with interpenetrating pores (1–20 μm). We proposed a new method for introducing the proteolytic enzyme and the aminopolysaccharide chitosan into the composition of polyester films. Composite films possessed necrolytic activity and were characterized by increased hydrophilicity. Properties of enzyme-containing films from a mixture of polymers (proteolytic activity, porous structure, and increased hydrophilicity) account for their use in the preparation of biodegradable wound coverings.

Keywords

Chitosan Trypsin Apply Biochemistry Proteolytic Enzyme Solvent Evaporation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© MAIK “Nauka/Interperiodica” 2006

Authors and Affiliations

  • N. R. Kil’deeva
    • 1
  • G. A. Vikhoreva
    • 1
  • L. S. Gal’braikh
    • 1
  • A. V. Mironov
    • 1
  • G. A. Bonartseva
    • 2
  • P. A. Perminov
    • 1
  • A. N. Romashova
    • 1
  1. 1.Moscow State Textile UniversityMoscowRussia
  2. 2.Bach Institute of BiochemistryRussian Academy of SciencesMoscowRussia

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