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Applied Biochemistry and Microbiology

, Volume 42, Issue 4, pp 392–395 | Cite as

Catalysis of the biodegradation of unusable medicines by Alkanotrophic rhodococci

  • I. B. Ivshina
  • M. I. Rychkova
  • E. V. Vikhareva
  • L. A. Chekryshkina
  • I. I. Mishenina
Article

Abstract

Experiments on the biodegradation of unusable medicines containing a phenolic hydroxy group by actinobacteria of the genus Rhodococcus were performed. Six species and sixty-four strains were tested. It was found that rhodococci could degrade paracetamol, and some R. ruber strains showed high levels of its degradation. An efficient method for the identification and quantification of paracetamol and the products of its conversion (p-aminophenol, pyrocatechol, and hydroquinone) immediately in the culture liquid was developed. Conditions for the complete biodegradation of paracetamol dosage forms (pills) were optimized. The experimental results can be applied to the development of biotechnological methods for degrading medicines: faked, rejected, or those that are expired.

Keywords

Biodegradation Apply Biochemistry Paracetamol Actinobacteria Rhodococcus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© MAIK “Nauka/Interperiodica” 2006

Authors and Affiliations

  • I. B. Ivshina
    • 1
  • M. I. Rychkova
    • 1
  • E. V. Vikhareva
    • 2
  • L. A. Chekryshkina
    • 2
  • I. I. Mishenina
    • 2
  1. 1.Institute of Ecology and Genetics of MicroorganismsUral Division of the Russian Academy of SciencesPermRussia
  2. 2.Perm State Pharmaceutical AcademyPermRussia

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