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Composite biomolecule/PEDOT materials for neural electrodes
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  • Open Access
  • Published: 10 November 2008

Composite biomolecule/PEDOT materials for neural electrodes

  • Maria Asplund1,
  • Hans von Holst1,2 &
  • Olle Inganäs3 

Biointerphases volume 3, pages 83–93 (2008)Cite this article

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Abstract

Electrodes intended for neural communication must be designed to meet both the electrochemical and biological requirements essential for long term functionality. Metallic electrode materials have been found inadequate to meet these requirements and therefore conducting polymers for neural electrodes have emerged as a field of interest. One clear advantage with polymer electrodes is the possibility to tailor the material to have optimal biomechanical and chemical properties for certain applications. To identify and evaluate new materials for neural communication electrodes, three charged biomolecules, fibrinogen, hyaluronic acid (HA), and heparin are used as counterions in the electrochemical polymerization of poly(3,4-ethylenedioxythiophene) (PEDOT). The resulting material is evaluated electrochemically and the amount of exposed biomolecule on the surface is quantified. PEDOT:biomolecule surfaces are also studied with static contact angle measurements as well as scanning electron microscopy and compared to surfaces of PEDOT electrochemically deposited with surfactant counterion polystyrene sulphonate (PSS). Electrochemical measurements show that PEDOT:heparin and PEDOT:HA, both have the electrochemical properties required for neural electrodes, and PEDOT:heparin also compares well to PEDOT:PSS. PEDOT:fibrinogen is found less suitable as neural electrode material.

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Author information

Authors and Affiliations

  1. School of Technology and Health, Royal Institute of Technology, SE-14152, Huddinge, Alfred Nobels Allé 10, Sweden

    Maria Asplund & Hans von Holst

  2. Institution of Laboratory Medicine, Karolinska Institutet, and Department of Neurosurgery, Karolinska University Hospital, SE-141 86, Stockholm, Sweden

    Hans von Holst

  3. Biomolecular and Organic Electronics, The Department of Physics, Chemistry and Biology, Linköping University, SE-581 83, Linköping, Sweden

    Olle Inganäs

Authors
  1. Maria Asplund
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  2. Hans von Holst
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  3. Olle Inganäs
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Cite this article

Asplund, M., von Holst, H. & Inganäs, O. Composite biomolecule/PEDOT materials for neural electrodes. Biointerphases 3, 83–93 (2008). https://doi.org/10.1116/1.2998407

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  • Received: 21 July 2008

  • Accepted: 10 September 2008

  • Published: 10 November 2008

  • Issue Date: September 2008

  • DOI: https://doi.org/10.1116/1.2998407

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