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Annals of Biomedical Engineering

, Volume 28, Issue 5, pp 556–564 | Cite as

Enhancing the Uptake of Chemotherapeutic Drugs into Tumors using an “Artificial Lymphatic System”

  • Gene R. DiResta
  • Jongbin Lee
  • John H. Healey
  • Steven M. Larson
  • Ehud Arbit
Article

Abstract

This paper presents findings from uptake studies to evaluate the ability of an “artificial lymphatic system” (ALS) to enhance large and small molecular weight drug transport into solid tumors and the therapeutic effect of the additional drug on their growth. These studies also served to test the effectiveness of an implantable multidrain ALS. Walker 256, Neuroblastoma, and Sarcoma dual-tumor models were used to evaluate the effect of ALS aspiration on the uptake of 3F8 monoclonal antibody, and doxorubicin. A tumor shrinkage experiment using Walker 256 dual tumors was used to evaluate the efficacy of an implantable ALS with cyclophosphamide chemotherapy. Drug uptake significantly increased in all aspirated tumors; 3F8 uptake was enhanced 37.4% in the Walker and 93.1% in the Neuroblastoma tumor lines (p < 0.05). Doxorubicin uptake increased 23.2%; in Sarcoma tumor (p < 0.05). The shrinkage study demonstrated that one-drain aspirated tumors shrank 90% faster (p < 0.01) than control tumors, while three-drain aspirated tumors shrank 123% faster than control tumors (p < 0.01). © 2000 Biomedical Engineering Society.

PAC00: 8719Tt, 8719Xx, 8780-y, 8719Uv

Interstitial fluid pressure Artificial lymphatic system Walker 256 Sarcoma 3F8 NMB-7 Neuroblastoma Doxorubicin Monoclonal antibody Cyclophosphamide 

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Copyright information

© Biomedical Engineering Society 2000

Authors and Affiliations

  • Gene R. DiResta
    • 1
  • Jongbin Lee
    • 2
  • John H. Healey
    • 1
  • Steven M. Larson
    • 2
  • Ehud Arbit
    • 3
  1. 1.Department of Surgery/Orthopaedic ServiceMemorial Sloan Kettering Cancer Center'sUSA
  2. 2.Nuclear Medicine Research LaboratoryMemorial Sloan Kettering Cancer CenterNew York
  3. 3.Department of SurgeryStaten Island University Medical Center'sNew York

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