Annals of Biomedical Engineering

, Volume 31, Issue 10, pp 1162–1170

Effects of Hydration and Fixed Charge Density on Fluid Transport in Charged Hydrated Soft Tissues

  • Wei Yong Gu
  • Hai Yao

DOI: 10.1114/1.1615576

Cite this article as:
Gu, W.Y. & Yao, H. Annals of Biomedical Engineering (2003) 31: 1162. doi:10.1114/1.1615576


The effects of tissue hydration and fixed charge density on hydraulic permeability and creep behavior of cartilaginous tissues have been investigated using the triphasic theory and finite element methods. The empirical model for hydraulic permeability of uncharged gels and Mackie and Meares (1955) model for ion diffusivity were used in the numerical analysis. The hydraulic permeabilities of normal and trypsin-treated porcine annulus fibrosus tissues were measured indirectly. Analysis of the experimental data from this study and in literature indicates that the water content plays a more important role in regulating tissue permeability than fixed charge density for normal tissues. A change in glycosaminoglycan content will change both triphasic closed-circuit (or intrinsic) and biphasic open-circuit permeabilities of cartilaginous tissues. Analysis also shows that both fixed charge density and water content play an important role in tissue creep response. This study adds new knowledge to the permeability and creep behavior of cartilaginous tissues and is important for understanding the nutrition in intervertebral disk. © 2003 Biomedical Engineering Society.

PAC2003: 8719Tt, 8710+e, 8719Uv

Annulus fibrosus Intervertebral disk Fluid transport Tissue hydration Fixed charge density Hydraulic permeability Triphasic theory Finite element method 

Copyright information

© Biomedical Engineering Society 2003

Authors and Affiliations

  • Wei Yong Gu
    • 1
  • Hai Yao
    • 1
  1. 1.Tissue Biomechanics Laboratory, Department of Biomedical EngineeringUniversity of MiamiCoral Gables

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