Annals of Biomedical Engineering

, Volume 31, Issue 4, pp 412–419 | Cite as

Modeling the Adaptive Permeability Response of Porcine Iliac Arteries to Acute Changes in Mural Shear

  • A. L. Hazel
  • D. M. Grzybowski
  • M. H. Friedman
Article

Abstract

The hypothesis that much of the uptake of macromolecules by the vascular wall takes place while the endothelial lining is adapting to changes in its hemodynamic environment is being tested by a series of in vivo measurements of the uptake of Evans-blue-dye-labeled albumin by porcine iliac arteries subjected to acute changes in blood flow. The uptake data are interpreted through an ad hoc model of the dynamic permeability response that is proposed to accompany alterations in mural shear.The model is able to correlate, with a single set of parameters, the vascular response to a variety of experimental protocols, including sustained step increases and decreases in shear, and alternations in shear of various periods. The best-fit parameters of the model suggest that the adaptive response to an increase in shear proceeds with a latency of ∼ 1.5 min and a time constant of ∼ 90 min that is substantially shorter than the response to a decrease in shear. © 2003 Biomedical Engineering Society.

PAC2003: 8710+e, 8719Rr, 8719Uv

Atherogenesis Hemodynamics Endothelium Wall shear stress 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

REFERENCES

  1. 1.
    Davies, P. F., C. F. Dewey, Jr., S. R. Bussolari, E. J. Gordon, and M. A. Gimbrone, Jr., Influence of hemodynamic forces on vascular endothelial function. J. Clin. Invest.73:1121–1129, 1984.Google Scholar
  2. 2.
    Friedman, M. H., and D. L. Fry. Arterial permeability dynamics and vascular disease. Atherosclerosis (Berlin)104:189–194, 1993.Google Scholar
  3. 3.
    Friedman, M. H., J. M. Henderson, J. A. Aukerman, and P. A. Clingan. Effect of periodic alterations in shear on vascular macromolecular uptake. Biorheology37:265–277, 2000.Google Scholar
  4. 4.
    Fry, D. L. Hemodynamic forces in atherogenesis. In: Cerebrovascular Diseases, edited by P. Scheinberg. New York: Raven, 1976, pp. 77–95.Google Scholar
  5. 5.
    Fry, D. L.Aortic Evans blue dye accumulation: Its measurement and interpretation. Am. J. Physiol.232:H204–H222, 1977.Google Scholar
  6. 6.
    Hazel, A. L., and M. H. Friedman. Method for assessing the need for case-specific hemodynamics: Application to the distribution of vascular permeability. Ann. Biomed. Eng.28:1300–1306, 2000.Google Scholar
  7. 7.
    Helmlinger, G., B. C. Berk, and R. M. Nerem. Pulsatile and steady flow-induced calcium oscillations in single cultured endothelial cells. J. Vasc. Res.33:360–369, 1996.Google Scholar
  8. 8.
    Helmlinger, G., R. V. Geiger, S. Schreck, and R. M. Nerem. Effects of pulsatile flow on cultured vascular endothelial cell morphology. ASME J. Biomech. Eng.113:123–131, 1991.Google Scholar
  9. 9.
    Henderson, J. M., J. A. Aukerman, P. A. Clingan, and M. H. Friedman. Effect of alterations in femoral artery flow on abdominal vessel hemodynamics in swine. Biorheology36:257–266, 1999.Google Scholar
  10. 10.
    Jo, H., R. O. Dull, T. M. Hollis, and J. M. Tarbell. Endothelial albumin permeability is shear dependent, time dependent, and reversible. Am. J. Physiol.260:H1992–H1996, 1991.Google Scholar
  11. 11.
    Kataoka, N., and M. Sato. The change of F-actin distribution and morphology of cultured bovine aortic endothelial cells in the early stage of fluid shear stress exposure. Trans. Jpn. Soc. Mech. Eng., Ser. B64:1801–1808, 1998.Google Scholar
  12. 12.
    Kawarabayashi, M., M. Ikeda, and K. Tanishita. Effect of pulsatile flow on the albumin permeability across the endothelial cell layer. In: Proceedings of the 2001 Bioengineering Conference, New York: ASME, 2001, Vol. 50, pp. 673–674.Google Scholar
  13. 13.
    Levesque, M. J., and R. M. Nerem. The elongation and orientation of cultured endothelial cells in response to shear stress. ASME J. Biomech. Eng.107:341–347, 1985.Google Scholar
  14. 14.
    Noria, S., D. B. Cowan, A. I. Gotlieb, and L. Langille. Transient and steady-state effects of shear stress on endothelial cell adherens junctions. Circ. Res.85:504–514, 1999.Google Scholar
  15. 15.
    Remuzzi, A., C. F. Dewey, Jr., P. F. Davies, and M. A. Gimbrone, Jr.Orientation of endothelial cells in shear fields. Biorheology21:617–630, 1984.Google Scholar
  16. 16.
    Seebach, J., P. Dieterich, F. Luo, H. Schillers, D. Vestweber, H. Oberleithner, H.-J. Galla, and H.-J. Schnittler. Endothelial barrier function under laminar fluid shear stress. Lab. Invest.80:1819–1831, 2000.Google Scholar
  17. 17.
    Sho, E., M. Sho, T. M. Singh, C. Xu, C. K. Zarins, and H. Masuda. Blood flow decrease induces apoptosis of endothelial cells in previously dilated arteries resulting from chronic high blood flow. Arterioscler., Thromb., Vasc. Biol.21:1139–1145, 2001.Google Scholar
  18. 18.
    Sill, H. W., Y. S. Chang, J. R. Artman, J. A. Frangos, T. M. Hollis, and J. M. Tarbell. Shear stress increases hydraulic conductivity of cultured endothelial monolayers. Am. J. Physiol.268:H535–H543, 1995.Google Scholar
  19. 19.
    Waters, C. M.Flow-induced modulation of the permeability of endothelial cells cultured on microcarrier beads. J. Cell Physiol.168:403–411, 1996.Google Scholar

Copyright information

© Biomedical Engineering Society 2003

Authors and Affiliations

  • A. L. Hazel
    • 1
  • D. M. Grzybowski
    • 2
  • M. H. Friedman
    • 3
  1. 1.Department of MathematicsUniversity of ManchesterManchesterU.K
  2. 2.Biomedial Engineering CenterThe Ohio State UniversityColumbus
  3. 3.Department of Biomedical EngineeringDuke UniversityDurham

Personalised recommendations