Method for Assessing the Need for Case-Specific Hemodynamics: Application to the Distribution of Vascular Permeability
- 38 Downloads
A common approach to understanding the role of hemodynamics in atherogenesis is to seek relationships between parameters of the hemodynamic environment, and the distribution of tissue variables thought to be indicative of early disease. An important question arising in such investigations is whether the distributions of tissue variables are sufficiently similar among cases to permit them to be described by an ensemble average distribution. If they are, the hemodynamic environment needs be determined only once, for a nominal representative geometry; if not, the hemodynamic environment must be obtained for each case. A method for classifying distributions from multiple cases to answer this question is proposed and applied to the distributions of the uptake of Evans blue dye labeled albumin by the external iliac arteries of swine in response to a step increase in flow. It is found that the uptake patterns in the proximal segment of the arteries, between the aortic trifurcation and the ostium of the circumflex iliac artery, show considerable case-to-case variability. In the distal segment, extending to the deep femoral ostium, many cases show very little spatial variation, and the patterns in those that do are similar among the cases. Thus the response of the distal segment may be understood with fewer simulations, but the proximal segment has more information to offer. © 2000 Biomedical Engineering Society.
PAC00: 8719Uv, 8719Xx
Unable to display preview. Download preview PDF.
- 1 Davies, P. F., C. F. Dewey, Jr., S. R. Bussolari, E. J. Gordon, and M. A. Gimbrone, Jr. Influence of hemodynamic forces on vascular endothelial function. In vitro studies of shear stress and pinocytosis in bovine aortic cells. J. Clin. Invest. 73:1121-1129, 1984.Google Scholar
- 2Friedman, M. H. Atherosclerosis research using vascular flow models. J. Biomech. Eng. 115:595-601, 1993.Google Scholar
- 3Friedman, M. H., and D. L. Fry. Arterial permeability dynamics and vascular disease. Atherosclerosis (Berlin)104:189-194, 1993.Google Scholar
- 4Friedman, M. H., J. M. Henderson, J. A. Aukerman, P. A. Clingan, and D. L. Fry. Effect of alternating shear levels on 1305 Assessing the Need for Case-Specific Hemodynamics vascular macromolecular uptake. Biorheol. 2000 (in press).Google Scholar
- 5 Fry, D. L. Acute vascular endothelial changes associated with increased blood velocity gradients. Circ. Res. 22:165-197, 1968.Google Scholar
- 6 Fry, D. L. Aortic Evans Blue dye accumulation: Its measurement and interpretation. Am. J. Physiol. 232:H204-H222, 1977.Google Scholar
- 7Henderson, J. M., J. A. Aukerman, P. A. Clingan, and M. H. Friedman. Effect of alterations in femoral artery flow on abdominal vessel hemodynamics in swine. Biorheology36:257-266, 1999.Google Scholar
- 8 Huddleston, M. J. Computational flow modeling in the porcine aortic trifurcation. Master's thesis, Ohio State University, 1999.Google Scholar
- 9Lawryshyn, Y. A., J. A. Moore, A. Kirpilani, M. Ojha, and C. R. Ethier. Modeling blood flow in a human right coronary artery (RCA). Ann. Biomed. Eng. 26:S55, 1998.Google Scholar
- 10Okano, M., and Y. Yoshida. Endothelial cell morphometry of atherosclerotic lesions and flow profiles at aortic bifurcations in cholesterol-fed rabbits. J. Biomech. Eng. 114:301-308, 1992.Google Scholar
- 11 Rindfleisch, E. A. Manual of Pathological Histology, translated by E. B. Baxter, London: New Sydenham Society, 1872, Vol. I.Google Scholar