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Annals of Biomedical Engineering

, Volume 28, Issue 8, pp 979–990 | Cite as

Integrative Models for Understanding the Structural Basis of Regional Mechanical Dysfunction in Ischemic Myocardium

  • Reza Mazhari
  • Andrew D. McCulloch
Article

Abstract

Myocardial ischemia and many other cardiac pathologies are associated with regional ventricular dysfunction. Since the distributions of stress and material properties cannot be measured directly in intact myocardium, understanding how regional alterations in myocardial strain or segment function are related to underlying cellular dysfunction must be deduced from theoretical models. Here, we describe how anatomically detailed, three-dimensional computational models can be used in conjunction with experimental or clinical studies to elucidate the structural basis of regional dysfunction in acutely ischemic and ischemic-reperfused (“stunned”) myocardium in vivo. Integrative experimental and computational analysis shows that: (1) in acutely ischemic myocardium, the transition from abnormal systolic strain in the ischemic region to normal shortening in adjacent, normally perfused tissue is governed primarily by systolic blood pressure and regional fiber orientation rather than the geometry of the perfusion boundary; and (2) in stunned myocardium, the degree of reperfusion injury to the contractile apparatus may be uniform across the wall thickness despite observations that the extent of ischemia and the impairment of regional strain during reperfusion are both significantly greater in the subendocardium. © 2000 Biomedical Engineering Society.

PAC00: 8719Hh, 8719Uv, 8719Ff, 8719Rr, 8710+e

Stunned myocardium Finite-element model Diastolic properties Functional border zone Transmural function Regional blood flow 

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Copyright information

© Biomedical Engineering Society 2000

Authors and Affiliations

  • Reza Mazhari
    • 1
  • Andrew D. McCulloch
    • 1
  1. 1.Department of Bioengineering, The Whitaker Institute for Biomedical EngineeringUniversity of CaliforniaSan Diego, La Jolla

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