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Establishment and characterization of a human malignant choroids plexus papilloma cell line (HIBCPP)

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Abstract

A cell line designated “HIBSPP” was established from a human malignant choroids plexus papilloma of 29-year-old Japanese woman. This line grew well without interruption for 3 years and was subcultivated over 70 times. The cells were spindle, oval, and polygonal in shape, and neoplastic and pleomorphic features, a jigsaw puzzle-like arrangement, multilayering and forming papillary shuctures without contact inhibition. The cells proliferated slowly, and the population doubling time was about 69 hours. The chromosome number showed a wide distribution of aneuploidy. The mode was in the hypo-tetraploid range, and many marker chromosomes were observed. The culture cells were easily transplanted into the subcutis of nude mice and produced the tumor resembling the original tumor.

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Authors and Affiliations

  1. Ishiwata Obstetrics and Gynecology Hospital, 1-4-21, Kami-Mito, Mito-shi, 310-0041, Ibaraki-ken

    Isamu Ishiwata & Chieko Ishiwata

  2. Department of Obstetrics and Gynecology, Fujita Health University School of Medicine, Japan

    Emiko Ishiwata

  3. Mito National Hospital, Japan

    Yoshiro Sato

  4. Dept. of Obstetrics and Gynecology, School of Med. St. Marianna, Japan

    Kazushige Kiguchi

  5. Department of Anatomy, Jikei University, School of Medicine, Japan

    Toshiaki Tachibana, Hisashi Hashimoto & Hiroshi Ishikawa

Authors
  1. Isamu Ishiwata
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  2. Chieko Ishiwata
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  3. Emiko Ishiwata
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  4. Yoshiro Sato
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  5. Kazushige Kiguchi
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  6. Toshiaki Tachibana
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  7. Hisashi Hashimoto
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  8. Hiroshi Ishikawa
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Ishiwata, I., Ishiwata, C., Ishiwata, E. et al. Establishment and characterization of a human malignant choroids plexus papilloma cell line (HIBCPP). Hum Cell 18, 67–72 (2005). https://doi.org/10.1111/j.1749-0774.2005.tb00059.x

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  • DOI: https://doi.org/10.1111/j.1749-0774.2005.tb00059.x

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