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Sleep in patients with Chiari-I malformations

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Abstract

Our objective was to better define sleep in patients with Chiari-I malformations (CIM). Sixteen female CIM patients and 34 healthy female controls underwent sagittal-axial T1 and T2 brain magnetic resonance imaging. Subjects completed the Epworth Sleepiness Scale, Insomnia Severity Index, Berlin Questionnaire, modified Johns Hopkins telephone restless legs syndrome (RLS) diagnostic interview, and individual questions on sleep latency and duration. Compared to controls, CIM patients were sleepier, had more insomnia and longer sleep latencies, shorter total sleep times, more RLS, and had greater risk of sleep-disordered breathing (all itP < 0.05). These findings support an association between CIM neuropathology and impaired sleep respiration, regulation, and increased RLS.

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Authors and Affiliations

  1. Department of Neurology, University of Washington and University of Washington Medicine Sleep Center, Box 359803, 325 Ninth Avenue, Seattle, WA, 98104-2499, USA

    Nathaniel F. Watson

  2. Department of Medicine, University of Washington, USA

    Dedra Buchwald, Carolyn Noonan & Kenneth Maravilla

  3. Department of Epidemiology, University of Washington and Vietnam Era Twin Registry, Seattle VA Epidemiologic Research and Education Center, USA

    Jack Goldberg

  4. Department of Neurological Surgery, University of Washington, Seattle, Washington, USA

    Richard G. Ellenbogen

Authors
  1. Nathaniel F. Watson
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  2. Dedra Buchwald
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  3. Carolyn Noonan
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  4. Jack Goldberg
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  5. Kenneth Maravilla
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  6. Richard G. Ellenbogen
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Corresponding author

Correspondence to Nathaniel F. Watson.

Additional information

This work was supported by NIH grant R01 (AR 47678-01A1) and the National Fibromyalgia Research Association.

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Watson, N.F., Buchwald, D., Noonan, C. et al. Sleep in patients with Chiari-I malformations. Sleep Biol. Rhythms 8, 261–266 (2010). https://doi.org/10.1111/j.1479-8425.2010.00456.x

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  • DOI: https://doi.org/10.1111/j.1479-8425.2010.00456.x

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