Hastatoside and verbenalin are sleep-promoting components in Verbena officinalis
- 15 Downloads
Herbal tea made from Verbena officinalis (V. officinalis) has traditionally been used for the treatment of insomnia and other nervous conditions. In this study, we examined the sleep-promoting activity of hastatoside, verbenalin, and verbascoside, which are the major iridoids (hastatoside and verbenalin) and polyphenol (verbascoside) components responsible for the pharmacological activity of V. officinalis, by electroencephalographic analysis of rats after oral administration of the compounds. Hastatoside (0.64 mmol/kg of body weight) and verbenalin (1.28 mmol/kg of body weight) increased the total time of non-rapid eye movement sleep during a 9-h period from 23.00 to 08.00 hours by 81% and 42%, respectively, with a lag time of about 3–5 h after the administration at 20.00 hours (lights-off time). Both compounds also increased the delta activity during non-rapid eye movement sleep. However, verbascoside had no effect on the amount of sleep. Therefore, hastatoside and verbenalin are major sleep-promoting components of V. officinalis.
Key wordshastatoside non-rapid eye movement sleep rat verbenaceae verbenalin
Unable to display preview. Download preview PDF.
- 1.Rimpler H, Schaefer B. Hastatosid, ein neues Iridoid aus Verbena hastata 1 und Verbena officinalis 1. Z Naturforsh. Sect. C 1979; 34: 311–8.Google Scholar
- 2.Deepak M, Handa SS. Chemical standardization of V officinalis. Abstracts of the 49th Indian Pharmaceutical Congress; 20 Dec 1997, Trivandrum, India, 1997; C-1/P25.Google Scholar
- 3.Singh B, Saxena AK, Chandan BK et al. Hepatoprotective activity of verbenalin on experimental liver damage in rodents. Fitoterapia 1998; 69: 135–40.Google Scholar
- 4.Deepak M, Chandrareddy UD, Handa SS. Verbascoside — a promising phenylpropanoid. Indian Drugs 1999; 36: 336–45.Google Scholar
- 6.Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates. Academic Press: San Diego, CA, 1997.Google Scholar