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Sleep and Biological Rhythms

, Volume 5, Issue 2, pp 126–131 | Cite as

Glycine ingestion improves subjective sleep quality in human volunteers, correlating with polysomnographic changes

  • Wataru Yamadera
  • Kentaro InagawaEmail author
  • Shintaro Chiba
  • Makoto Bannai
  • Michio Takahashi
  • Kazuhiko Nakayama
Original Article

Abstract

In human volunteers who have been continuously experiencing unsatisfactory sleep, effects of glycine ingestion (3 g) before bedtime on subjective sleep quality were investigated, and changes in polysomnography (PSG) during sleep were analyzed. Effects on daytime sleepiness and daytime cognitive function were also evaluated. Glycine improved subjective sleep quality and sleep efficacy (sleep time/in-bed time), and shortened PSG latency both to sleep onset and to slow wave sleep without changes in the sleep architecture. Glycine lessened daytime sleepiness and improved performance of memory recognition tasks. Thus, a bolus ingestion of glycine before bedtime seems to produce subjective and objective improvement of the sleep quality in a different way than traditional hypnotic drugs such as benzodiazepines.

Key words

amino acid glycine slow wave sleep latency St Mary’s Hospital Sleep Questionnaire Stanford Sleepiness Scale 

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Copyright information

© Japanese Society of Sleep Research 2007

Authors and Affiliations

  • Wataru Yamadera
    • 1
  • Kentaro Inagawa
    • 2
    Email author
  • Shintaro Chiba
    • 3
  • Makoto Bannai
    • 2
  • Michio Takahashi
    • 2
  • Kazuhiko Nakayama
    • 1
  1. 1.Department of PsychiatryJikei University School of MedicineTokyoJapan
  2. 2.Research Institute for Health FundamentalsAjinomoto Co. Inc.Kawasali-shi, 210-8681 KanagawaJapan
  3. 3.Ohta Memorial Sleep CenterOhta General HospitalKawasakiJapan

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