Sleep and Biological Rhythms

, Volume 4, Issue 1, pp 75–77 | Cite as

Subjective effects of glycine ingestion before bedtime on sleep quality

  • Kentaro InagawaEmail author
  • Takenori Hiraoka
  • Tohru Kohda
  • Wataru Yamadera
  • Michio Takahashi
Short Paper


The effects of glycine on sleep quality were examined in a randomized double-blinded cross-over trial. The volunteers, with complaints about the quality of their sleep, ingested either glycine (3 g) or placebo before bedtime, and their subjective feeling in the following morning was evaluated with the St. Mary’s Hospital Sleep Questionnaire and Space-Aeromedicine Fatigue Checklist. The glycine ingestion significantly improved the following elements: “fatigue”, “liveliness and peppiness”, and “clear-headedness”. These results suggest that glycine produced a good subjective feeling after awakening from sleep.

Key words

amino acid glycine subjective effect on sleep 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Cooper JR, Bloom FE, Roth RH. Amino acid transmitters. In: Cooper JR, Bloom FE and Roth RH, eds. The Biochemical Basis of Neuropharmacology, 8th edn. Oxford University Press: Oxford, 2003; 105–50.Google Scholar
  2. 2.
    File SE, Fluck E, Fernandes C. Beneficial effects of glycine (BioglycineR) on memory and attention in young and middle-aged adults. J. Clin. Psychopharmacol. 1999; 19: 506–12.CrossRefPubMedGoogle Scholar
  3. 3.
    Ellis BW, Johns MW, Lancaster R, Raptopoulos P, Angelopoulos N, Priest RG. The St. Mary’s hospital sleep questionnaire: a study of reliability. Sleep 1981; 4: 93–7.PubMedGoogle Scholar
  4. 4.
    Uchiyama M, Ohta K, Okawa M. Evaluation standards of sleep and sleep disorder. In: Matsushita M, ed. Encyclopedia of Clinical Psychiatry, Vol. 13, Sleep Disorder. Nakayama Shoten: Tokyo, 1999; 489–98 (in Japanese).Google Scholar
  5. 5.
    Harris DA, Pegram GV, Hartman BO. Performance and fatigue in experimental double-crew transport missions. Aerospace Med. 1971; 42: 980–6.PubMedGoogle Scholar
  6. 6.
    Yamadera W. Psychophysical and psychological consequences after surgical treatment of obstructive sleep apnea syndrome. Psychiatr. Neurol. Jap 1994; 96: 903–32 (in Japanese).Google Scholar
  7. 7.
    Buysse DJ, Reynolds CF III, Monk TH, Berman SR, Kupfer DJ. The Pittsuburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatr. Res. 1989; 29: 193–213.CrossRefGoogle Scholar
  8. 8.
    Doi Y, Minowa M, Uchiyama M, Okawa M. Development of the Pittsuburgh Sleep Quality Index Japanese version. Jap. J. Psychiatr. Treat. 1998; 13: 755–68 (in Japanese).Google Scholar
  9. 9.
    Garlick PJ. The nature of human hazards associated with excessive intake of amino acids. J. Nutr. 2004; 134: 1633S–9S.PubMedGoogle Scholar

Copyright information

© Japanese Society of Sleep Research 2006

Authors and Affiliations

  • Kentaro Inagawa
    • 1
    Email author
  • Takenori Hiraoka
    • 2
  • Tohru Kohda
    • 2
  • Wataru Yamadera
    • 3
  • Michio Takahashi
    • 1
  1. 1.Research Institute for Health FundamentalsAjinomoto Co., Inc.Kasawaki-shiJapan
  2. 2.Health Service Development DepartmentAjinomoto Co., Inc.TokyoJapan
  3. 3.Department of PsychiatryJikei University School of MedicineTokyoJapan

Personalised recommendations