Abstract
Physiologic stresses have been reported to cause a lack of zinc. Obstructive sleep apnea syndrome (OSAS) is a disorder that gives stress, including sleep deprivation or hypoxia. Therefore, it is predicted that the serum zinc level might be decreased in OSAS patients. We studied 16 patients with OSAS who underwent polysomnogram. Of the 16 cases of the OSAS group, 5 cases showed hypozincemia, whereas no cases showing hypozincemia were observed in the non-OSAS group. The χ2-test revealed P < 0.05. Although administration of zinc was not performed until the time of blood drawing, three of the four cases with hypozincemia showed improvement.
References
Todd WR, Elvehjem C, Hart EB. Zinc in the nutrition of the rat. Am. J. Physiol. 1934; 107: 146–56.
Prasad AS, Miale A, Farid Z, Sandstead HH, Schulert AR. Zinc metabolism in patients with the syndrome of iron deficiency anemia, hepatosplenomegaly, dwarfism, and hypognadism. J. Lab. Clin. Med. 1963; 61: 537–49.
Prasad AS, Oberleas D. Thymidine kinase activity and incorporation of thymidine into DNA in zinc-deficient tissue. J. Lab. Clin. Med. 1974; 83: 634–9.
Cousins RJ. Absorption, transport, and hepatic metabolism of copper and zinc: special reference to metallothionein and ceruloplasmin. Physiol. Rev. 1985; 65: 238–309.
Yanagisawa H. Zinc deficiency and clinical practice. JMAJ 2004; 47: 359–64.
Oh SH, Deagen JT, Whanger PD, Weswig PH. Biological function of metallothionein. Its induction in rats by various stresses. Am. J. Physiol. 1978; 234: E282–5.
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Hattori, C., Suzuki, K., Kawakatsu, K. et al. Obstructive sleep apnea syndrome patients and hypozincemia. Sleep Biol. Rhythms 3, 45–46 (2005). https://doi.org/10.1111/j.1479-8425.2005.00157.x
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DOI: https://doi.org/10.1111/j.1479-8425.2005.00157.x