Journal of General Internal Medicine

, Volume 16, Issue 10, pp 656–662

Quality of life is impaired in men with chronic prostatitis

The chronic prostatitis collaborative research network
  • Mary McNaughton Collins
  • Michel A. Pontari
  • Michael P. O’Leary
  • Elizabeth A. Calhoun
  • Jill Santanna
  • J. Richard Landis
  • John W. Kusek
  • Mark S. Litwin
  • the Chronic Prostatitis Collaborative Research Network
Original Articles

Abstract

OBJECTIVE: Health-related quality of life (HRQOL) impairment may be a central component of chronic prostatitis for men afflicted with this condition. Our objective was to examine HRQOL, and factors associated with HRQOL, using both general and condition-specific instruments.

DESIGN: Chronic Prostatis Cohort (CPC) study.

SETTING: Six clinical research centers across the United States and Canada.

PARTICIPANTS: Two hundred seventy-eight men with chronic prostatitis.

MEASUREMENTS AND MAIN RESULTS: The Short Form 12 (SF-12) Mental Component Summary (MCS) and Physical Component Summary (PCS), and the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) were measures used. CPC subjects’ MCS scores (44.0±9.8) were lower than those observed in the most severe subgroups of patients with congestive heart failure and diabetes mellitus, and PCS scores (46.4±9.5) were worse than those among the general U.S. male population. Decreasing scores were seen in both domains with worsening symptom severity (P<.01). History of psychiatric disease and younger age were strongly associated with worse MCS scores, whereas history of rheumatologic disease was associated with worse PCS scores. Predictors of more severe NIH-CPSI scores included lower educational level and lower income; history of rheumatic disease was associated with higher scores.

CONCLUSIONS: Men with chronic prostatitis experience impairment in the mental and physical domains of general HRQOL, as well as condition-specific HRQOL. To optimize the care of men with this condition, clinicians should consider administering HRQOL instruments to their patients to better understand the impact of the condition on patients’ lives.

Key words

prostatis health-related quality of life 

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References

  1. 1.
    Stewart AL, Sherbourne CD, Hays RD. Summary and discussion of MOS measures In: Stewart AL, Ware JE, eds. Measuring Functioning and Well-Being: The Medical Outcomes Study Approach. Durham, NC: Duke University Press; 1992.Google Scholar
  2. 2.
    Guyatt GH, Feeny DH, Patrick DL. Measuring health-related quality of life. Ann Intern Med. 1993;118(8):622–9.PubMedGoogle Scholar
  3. 3.
    Krieger JN, Nyberg L Jr., Nickel JC. NIH consensus definition and classification of prostatitis. [letter]. JAMA. 1999;282(3):236–7.PubMedCrossRefGoogle Scholar
  4. 4.
    McNaughton Collins M, Stafford R, O’Leary M, Barry M. How common is prostatitis? A national survey of physician visits. J Urol. 1998;159:1224–8.CrossRefGoogle Scholar
  5. 5.
    Roberts RO, Lieber MM, Rhodes T, Girman CJ, Bostwick DG, Jacobsen SJ. Prevalence of a physician-assigned diagnosis of prostatitis: the Olmsted County Study of Urinary Symptoms and Health Status Among Men. Urology. 1998;51(4):578–84.PubMedCrossRefGoogle Scholar
  6. 6.
    Egan KJ, Krieger JL. Chronic abacterial prostatitis—a urological chronic pain syndrome? [see comments]. Pain. 1997;69(3):213–8.PubMedCrossRefGoogle Scholar
  7. 7.
    Nickel JC. Effective office management of chronic prostatitis. Urol Clin North Am. 1998;25(4):677–84.PubMedCrossRefGoogle Scholar
  8. 8.
    Krieger JN, Egan KJ, Ross SO, Jacobs R, Berger RE. Chronic pelvic pains represent the most prominent urogenital symptoms of “chronic prostatitis”. Urology. 1996;48(5):715–21; discussion 721–2.PubMedCrossRefGoogle Scholar
  9. 9.
    McNaughton Collins M, MacDonald R, Wilt TJ. Diagnosis and treatment of chronic abacterial prostatitis: a systematic review. Ann Intern Med. 2000;133:367–81.Google Scholar
  10. 10.
    Roberts RO, Lieber MM, Bostwick DG, Jacobsen SJ. A review of clinical and pathological prostatitis syndromes. Urology. 1997;49(6):809–21.PubMedCrossRefGoogle Scholar
  11. 11.
    Lipsky BA. Prostatitis and urinary tract infection in men: what’s new; what’s true? Am J Med. 1999;106(3):327–34.PubMedCrossRefGoogle Scholar
  12. 12.
    Nickel JC. Prostatitis: myths and realities. [see comments]. Urology. 1998;51(3):362–6.PubMedCrossRefGoogle Scholar
  13. 13.
    Wenninger K, Helman J, Rothman I, Berghois J, Berger R. Sickness impact of chronic nonbacterial prostatitis and its correlates. J Urol. 1996;155:965–8.PubMedCrossRefGoogle Scholar
  14. 14.
    Bergner M, Bobbitt RA, Pollard WE, Martin DP, Gilson BS. The sickness impact profile: validation of a health status measure. Med Care. 1976;14(1):57–67.PubMedCrossRefGoogle Scholar
  15. 15.
    National Institutes of Health. Summary Statement. Bethesda, Md: National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases workshop on chronic prostatitis; 1995.Google Scholar
  16. 16.
    Nickel JC, Nyberg LM, Hennenfent M. Research guidelines for chronic prostatitis: consensus report from the first National Institutes of Health International Prostatitis Collaborative Network. Urology. 1999;54(2):229–33.PubMedCrossRefGoogle Scholar
  17. 17.
    Nickel JC, Johnston B, Downey J, et al. Pentosan polysulfate therapy for chronic nonbacterial prostatitis (chronic pelvic pain syndrome category IIIA): a prospective multicenter clinical trial. Urology. 2000;56(3):413–7.PubMedCrossRefGoogle Scholar
  18. 18.
    Nickel JC, Downey J, Johnston B, Clark J, Group TC. Predictors of patient response to antibiotic therapy for the chronic prostatitis/chronic pelvic pain syndrome: a prospective multicenter clinical trial. J Urol. 2001;165(5):1539–44.PubMedCrossRefGoogle Scholar
  19. 19.
    Meares EM, Stamey TA. Bacteriologic localization patterns in bacterial prostatitis and urethritis. Invest Urol. 1968;5(5):492–518.PubMedGoogle Scholar
  20. 20.
    Litwin MS, McNaughton-Collins M, Fowler FJ Jr, et al. The National Institutes of Health chronic prostatitis symptom index: development and validation of a new outcome measure. Chronic Prostatitis Collaborative Research Network. J Urol. 1999;162(2):369–75.PubMedCrossRefGoogle Scholar
  21. 21.
    Heitjan DF. Annotation: what can be done about missing data? Approaches to imputation. [comment]. Am J Public Health. 1997;87(4):548–50.PubMedCrossRefGoogle Scholar
  22. 22.
    Ware J Jr, Kosinski M, Keller SD. A 12-item short-form health survey: construction of scales and preliminary tests of reliability and validity. Med Care. 1996;34(3):220–33.PubMedCrossRefGoogle Scholar
  23. 23.
    Ware JE, Kosinski M, Keller SD. SF-12 Physical and Mental Health Summary Scales. 3rd Ed. Lincoln RL: QualityMetric Inc.; 1998.Google Scholar
  24. 24.
    Keltikangas-Jarvinen L, Mueller K, Lehtonen T. Illness behavior and personality changes in patients with chronic prostatitis during a two-year follow-up period. Eur Urol. 1989;16(3):181–4.PubMedGoogle Scholar
  25. 25.
    de la Rosette JJ, Ruijgrok MC, Jeuken JM, Karthaus HF, Debruyne FM. Personality variables involved in chronic prostatitis. Urology. 1993;42(6):654–62.PubMedCrossRefGoogle Scholar
  26. 26.
    Berghuis JP, Heiman JR, Rothman I, Berger RE. Psychological and physical factors involved in chronic idiopathic prostatitis. J Psychosom Res. 1996;41(4):313–25.PubMedCrossRefGoogle Scholar
  27. 27.
    Egan KJ, Krieger JN. Psychological problems in chronic prostatitis patients with pain. Clin J Pain. 1994;10(3):218–26.PubMedCrossRefGoogle Scholar
  28. 28.
    Alexander RB, Trissel D. Chronic prostatitis: results of an Internet survey. Urology. 1996;48(4):568–74.PubMedCrossRefGoogle Scholar
  29. 29.
    Koloski NA, Talley NJ, Boyce PM. The impact of functional gastrointestinal disorders on quality of life. Am J Gastroenterol. 2000;95(1):67–71.PubMedCrossRefGoogle Scholar
  30. 30.
    Mancuso CA, Peterson MG, Charlson ME. Effects of depressive symptoms on health-related quality of life in asthma patients. [In Process Citation]. J Gen Intern Med. 2000;15(5):301–10.PubMedCrossRefGoogle Scholar
  31. 31.
    Vinokur AD, Threatt BA, Vinokur-Kaplan D, Satariano WA. The process of recovery from breast cancer for younger and older patients. Changes during the first year. Cancer. 1990;65(5):1242–54.PubMedCrossRefGoogle Scholar
  32. 32.
    Kazis LE, Ren XS, Lee A, et al. Health status in VA patients: results from the Veterans Health Study. Am J Med Qual. 1999;14(1):28–38.PubMedCrossRefGoogle Scholar
  33. 33.
    Alexander RB, Brady F, Ponniah S. Autoimmune prostatitis: evidence of T cell reactivity with normal prostatic proteins. Urology. 1997;50(6):893–9.PubMedCrossRefGoogle Scholar
  34. 34.
    Alexander RB, Ponniah S, Hasday J, Hebel JR. Elevated levels of proinflammatory cytokines in the semen of patients with chronic prostatitis/chronic pelvic pain syndrome. Urology. 1998;52(5):744–9.PubMedCrossRefGoogle Scholar
  35. 35.
    Simon LJ, Landis JR, Erickson DR, Nyberg LM. The Interstitial Cystitis Data Base Study: concepts and preliminary baseline descriptive statistics. Urology. 1997;49(5A Suppl):64–75.PubMedCrossRefGoogle Scholar

Copyright information

© Blackwell Science Inc 2001

Authors and Affiliations

  • Mary McNaughton Collins
    • 1
  • Michel A. Pontari
    • 3
  • Michael P. O’Leary
    • 2
  • Elizabeth A. Calhoun
    • 5
  • Jill Santanna
    • 4
  • J. Richard Landis
    • 4
  • John W. Kusek
    • 6
  • Mark S. Litwin
    • 7
  • the Chronic Prostatitis Collaborative Research Network
  1. 1.the General Medicine Unit, Medical ServicesMassachusetts General HospitalBoston
  2. 2.the Department of Surgery, HMS, Division of Urologic SurgeryBrigham and Women’s HospitalBoston
  3. 3.the Department of UrologyTemple University School of MedicinePhiladelphia
  4. 4.the Center for Clinical Epidemiology and BiostatisticsUniversity of Pennsylvania Medical CenterPhiladelphia
  5. 5.the Institute for Health Services and Health Policy StudiesNorthwestern University Medical SchoolChicago
  6. 6.the Division of Kidney, Urologic, and Hematologic DiseasesNIH/NIDDKBethesda
  7. 7.the Department of Urology and Health ServicesUniversity of CaliforniaLos Angeles

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