Journal of Urban Health

, Volume 82, Supplement 1, pp i100–i108 | Cite as

Sustained reductions in drug use and depression symptoms from treatment for drug abuse in methamphetamine-dependent gay and bisexual men

  • James A. PeckEmail author
  • Cathy J. Reback
  • Xiaowei Yang
  • Erin Rotheram-Fuller
  • Steven Shoptaw


Methamphetamine abusers often complain of feelings of depression that can complicate accurately diagnosing these individuals during treatments for methamphetamine abuse. This article presents an examination of temporal associations between documented methamphetamine use and reported ratings of depression among 162 gay and bisexual male methamphetamine abusers who participated in a 16-week randomized clinical trial of four behavioral therapies for methamphetamine abuse. Methamphetamine use was measured using thrice-weekly urine samples analyzed for drug metabolite. Self-reported depressive symptoms were collected weekly using the Beck Depression Inventory (BDI). At treatment entry, 73.2% of participants rated their depressive symptoms as mild or higher in severity (BDI≥10), with 28.5% reporting BDI scores in the moderate to severe range (BDI≥19). All participants reported significant decreases in depressive symptoms from baseline through the end of treatment, regardless of treatment condition, HIV status, or mood disorder diagnosis. A mixed regression model showed methamphetamine use for up to 5 days prior to the BDI score strongly predicted depressive symptoms (F1,968=18.6, P<.0001), while BDI scores had no significant association with subsequent methamphetamine use. Findings show that behavioral methamphetamine abuse treatment yields reductions in methamphetamine use and concomitant depressive symptom ratings that are sustained to 1 year after treatment entry.


Depression methamphetamine drug abuse treatment gay men 


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Copyright information

© Oxford University Press on behalf of the New York Academy of Medicine 2005

Authors and Affiliations

  • James A. Peck
    • 1
    • 2
    Email author
  • Cathy J. Reback
    • 2
    • 3
  • Xiaowei Yang
    • 1
  • Erin Rotheram-Fuller
    • 1
    • 2
  • Steven Shoptaw
    • 1
    • 2
  1. 1.Integrated Substance Abuse Programs, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of MedicineUCLALos Angeles
  2. 2.Friends Research InstituteLos Angeles
  3. 3.Van Ness Recovery House Prevention DivisionLos Angeles

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