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Expression and possible role of neuronal calcium sensor-1 in the cerebellum

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Abstract

Neuronal calcium sensor-1 (NCS-1) is a member of EF-hand calcium-binding protein superfamily, which is considered to modulate synaptic transmission and plasticity. In this mini-review, we first summarize distribution of NCS-1 in the cerebellum. NCS-1 is mainly detected in postsynaptic sites, such as somata and dendrites of Purkinje cells, stellate/basket cells and granule cells. In addition, GABAergic inhibitory stellate/basket cell axon terminals also contain NCS-1. Secondly, we describe cerebellar compartmentation defined by NCS-1. The NCS-1 immunostaining displayed characteristic parasagittal-banding pattern in the Purkinje cell layer and molecular layer, whereas there were no apparent bands in the granule cell layer. The alternating positively and negatively NCS-1-labeled Purkinje cell clusters contributed to this cerebellar compartmentation. In contrast, stellate/ basket cells were uniformly NCS-1-positive throughout the cerebellum. Interestingly, NCS-1 and zebrin II exhibited a similar parasagittal-banding pattern. But it is noteworthy that NCS-1-negative/zebrin 11-positive Purkinje cell clusters were detected selectively in anterior lobule vermis and paraflocculus. These results suggest that NCS-1 defines a novel pattern of cerebellar cortical compartmentation. Lastly, we describe recent data suggesting some relationship between NCS-1 and cerebellar longterm depression-related molecules, and discuss the possible role of NCS-1 in the cerebellum.

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Authors and Affiliations

  1. Department of Anatomy and Neurobiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, 812-8582, Higashi-ku Fukuoka, Japan

    Shozo Jinno & Toshio Kosaka

  2. Division of Neuroscience, Baylor College of Medicine, Houston, Texas, USA

    Andreas Jeromin

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  1. Shozo Jinno
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  2. Andreas Jeromin
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Correspondence to Shozo Jinno.

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Jinno, S., Jeromin, A. & Kosaka, T. Expression and possible role of neuronal calcium sensor-1 in the cerebellum. The Cerebellum 3, 83–88 (2004). https://doi.org/10.1080/14734220310025187

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