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Coronavirus replication and pathogenesis: Implications for the recent outbreak of severe acute respiratory syndrome (SARS), and the challenge for vaccine development

Journal of NeuroVirology volume 10, pages 75–85 (2004)Cite this article

Abstract

A novel coronavirus has been recently identified as the causative agent of the severe acute respiratory syndrome (SARS) outbreak that has accounted for more than 8000 infected people worldwide. This review will discuss current knowledge on coronavirus replication, pathogenesis, evolution, and vaccine strategies, as well as the most recent findings on SARS coronavirus.

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  1. Department of Microbiology, University of Pennsylvania, School of Medicine, 36th Street and Hamilton Walk, 19104-6076, Philadelphia, PA, USA

    Sonia Navas-Martín & Susan R. Weiss

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  1. Sonia Navas-Martín
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Navas-Martín, S., Weiss, S.R. Coronavirus replication and pathogenesis: Implications for the recent outbreak of severe acute respiratory syndrome (SARS), and the challenge for vaccine development. Journal of NeuroVirology 10, 75–85 (2004). https://doi.org/10.1080/13550280490280292

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Keywords

  • coronavirus mutation
  • replication
  • SARS
  • vaccine