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The latency-related gene encoded by bovine herpesvirus 1 can suppress caspase 3 and caspase 9 cleavage during productive infection

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Abstract

When the bovine herpesvirus 1 (BHV-1) latency-related (LR) gene is inserted into the latency-associated transcript (LAT) locus of a herpes simplex virus type 1 (HSV-1) LAT deletion mutant, high levels of spontaneous reactivation from latency and enhanced pathogenesis occur. The LR gene, but not LAT, inhibits caspase 3 cleavage during productive infection. Plasmids containing LAT or the LR gene inhibit caspase 3 activation in transiently transfected cells, suggesting productive infection blocks certain antiapoptotic properties of LAT. These studies demonstrate a correlation between the enhanced pathogenic potential of CJLAT and the LR gene inhibiting caspase 3 cleavage during productive infection.

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Authors and Affiliations

  1. Department of Veterinary and Biomedical Sciences, University of Nebraska, Lincoln, Fair Street at East Campus Loop, 68583-0905, Lincoln, NE, USA

    Gail Henderson & Clinton Jones

  2. Department of Ophthalmology, University of California Irvine College of Medicine, Orange, California, USA

    Guey-Chuen Perng, Anthony B. Nesburn & Steven L. Wechsler

Authors
  1. Gail Henderson
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  2. Guey-Chuen Perng
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  3. Anthony B. Nesburn
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  4. Steven L. Wechsler
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  5. Clinton Jones
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Corresponding author

Correspondence to Clinton Jones.

Additional information

This study was supported by the Discovery Fund for Eye Research, the Skirball Program in Molecular Ophthalmology, Public Health Service grants to SW (EY11629, and EY12823) and CJ (1P20RR15635), and USDA grants to CJ (2000-02060, 2002-02450, and 2003-02213).

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Henderson, G., Perng, GC., Nesburn, A.B. et al. The latency-related gene encoded by bovine herpesvirus 1 can suppress caspase 3 and caspase 9 cleavage during productive infection. Journal of NeuroVirology 10, 64–70 (2004). https://doi.org/10.1080/13550280490261716

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  • DOI: https://doi.org/10.1080/13550280490261716

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