Abstract
Murine hepatitis virus A59 infection of the central nervous system (CNS) results in CNS demyelination in susceptible strains of mice. In infected B-cell-deficient mice, demyelination not only occurred but was also more severe than in parental C57BL/6 animals. This increase may be due to the persistence of virus in the CNS in the absence of B cells. In mice lacking antibody receptors or complement pathway activity, virus did not persist yet demyelination was similar to parental mice. In infected RAG1−/− mice, moderately sized, typical demyelinating lesions were identified. Therefore, demyelination can occur in the absence of B and T cells.
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This work was supported by NIH grant AI-36657 (YP) and National Multiple Sclerosis Society grants RG2585 (SRW) and RG2615 (EL). AM was partially supported by T32-CA-EY-07131 and T32-GM-07170 (NIH Veterinary Medical Scientist Training Program).
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Matthews, A.E., Lavi, E., Weiss, S.R. et al. Neither B cells nor T cells are required for CNS demyelination in mice persistently infected with MHV-A59. Journal of NeuroVirology 8, 257–264 (2002). https://doi.org/10.1080/13550280290049697
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DOI: https://doi.org/10.1080/13550280290049697