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Association of human herpesvirus 6 and human herpesvirus 7 with demyelinating diseases of the nervous system

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Abstract

Peripheral blood mononuclear cells and plasma of 113 patients with neurological disorders and 150 blood donors were analyzed for HHV-6 and HHV-7 sequences by PCR. The prevalence of HHV-6 was significantly higher in patients with multiple sclerosis (P < 0.01) than in cases of nondemyelinating diseases of the central and demyelinating diseases of the peripheral nervous systems and blood donors. HHV-6 viremia was found only in patients with multiple sclerosis, predominantly in the active phase of the disease. A significantly higher frequency of HHV-7 reactivation in patients with demyelinating diseases of the peripheral nervous system suggests also its association with demyelinating processes.

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Authors and Affiliations

  1. August Kirchenshtein Institute of Microbiology and Virology, University of Latvia, Ratsupites St. 1, LV-1067, Riga, Latvia

    V. Tomsone, S. Chapenko, S. Kozireva & M. Murovska

  2. Latvian Medical Academy, Riga, Latvia

    I. Logina & A. Millers

Authors
  1. V. Tomsone
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  2. I. Logina
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  3. A. Millers
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  4. S. Chapenko
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  5. S. Kozireva
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  6. M. Murovska
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Correspondence to V. Tomsone.

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Tomsone, V., Logina, I., Millers, A. et al. Association of human herpesvirus 6 and human herpesvirus 7 with demyelinating diseases of the nervous system. Journal of NeuroVirology 7, 564–569 (2001). https://doi.org/10.1080/135502801753248150

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  • DOI: https://doi.org/10.1080/135502801753248150

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