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Chemokines and central nervous system disorders

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Abstract

Chemokines and their receptors are large families of inflammatory molecules responsible for a number of biologic functions including the accumulation of leukocytes at tissue sites. Over the past 8 years, a number of studies have indicated a role for chemokines in the pathogenesis of CNS inflammatory diseases. This minireview provides a brief summary of our current knowledge of chemokines and CNS inflammatory diseases including experimental autoimmune encephalomyelitis, multiple sclerosis, virus-induced demyelinating diseases, Alzheimer’s disease, and central nervous system bacterial-induced diseases.

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  1. Department of Pathology, Northwestern University Medical School, 303 E. Chicago Avenue, W127, 60611, Chicago, IL, USA

    William J. Karpus

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Karpus, W.J. Chemokines and central nervous system disorders. Journal of NeuroVirology 7, 493–500 (2001). https://doi.org/10.1080/135502801753248079

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