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The Cerebellum

, Volume 2, Issue 1, pp 77–79 | Cite as

Cerebellar ataxia associated with anti-glutamic acid decarboxylase autoantibodies

  • M. Vianello
  • B. Tavolato
  • M. Armani
  • B. Giometto
Article

Abstract

Recent reports describe the detection of high titres of antibodies to glutamic acid decarboxylase (GAD-Ab) in the serum and cerebrospinal fluid (CSF) of patients with cerebellar ataxia. Most of these cases are females with Polyglandular Autoimmune Disorder who develop a chronic cerebellar syndrome. The CSF profile is in keeping with an autoimmune disorder and intrathecal GAD-Ab synthesis has been demonstrated. The ataxia could reverse after immunomodulatory treatments suggesting a possible pathogenetic role for GAD-Ab.

Keywords

cerebellar ataxia GAD antibodies autoimmunity 

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Copyright information

© Taylor & Francis 2003

Authors and Affiliations

  • M. Vianello
    • 1
  • B. Tavolato
    • 1
  • M. Armani
    • 1
  • B. Giometto
    • 1
  1. 1.Department of Neurological and Psychiatric Sciences (Second Clinic)University of PadovaPadovaItaly

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