The Cerebellum

, 1:137 | Cite as

The malformation of the cerebellarfissura prima: A tool for studying histogenetic processes

Article

Abstract

Due to its regular cytoarchitecture and the relatively low number of cell types, the development of the cerebellar cortex is a model of election for studies of morphogenetic processes. To unravel the cellular and molecular mechanisms that regulate cell development, migration and differentiation and the settling of local circuits, pertubation of the three-layered organization of the cerebellar cortex has been induced by X-ray irradiation or antimitotic drug. In this review we deal with some data about the incidence and development of the malformation of the cerebellarfissura prima of the rat, as an eligible model for histogenetic studies. The naturally occurring malformation of thefissura prima is characterized by the loss of the three-layered organization of folia and the presence of large masses of ectopic granuel cells. The malformation appears to be under genetic control, since the incidence of affected animals is consistent over extended breeding cycles, although the target of the eventual mutation is unknown. The observation of development of the malformation in infant rats suggests that a defect in meninges, and in particular in the pia mater, is a primary contributing factor. The molecules responsible for this defect are not identified, but they must be involved in basal lamina stabilization or destabilization. In fact, there is evidence that meninges do develop during first stages of histogenesis and only later degenerate. A possible correlation with certain human pathologies that involve defects in foliation is discussed.

Keywords

anatomical malformation cerebellum development fissura prima 

References

  1. 1.
    Larsell O. The morphogenesis and adult pattern of the lobules and fissures of the cerebellum of the white rat. J Comp Neurol 1952; 97: 281–356.PubMedCrossRefGoogle Scholar
  2. 2.
    Altman J, Bayer SA. Embryonic development of the rat cerebellum. III. Regional differences in the time of origin, migration, and settling of Purkinje cells. J Comp Neurol 1985; 231: 42–65.PubMedCrossRefGoogle Scholar
  3. 3.
    Ramon Y, Cajal S. Histologie du système nerveux de l’homme et des vertébrés. Paris: Maloine, 1911.Google Scholar
  4. 4.
    Estable C. Notes sur la structure comparative de l’écorce céré- belleuse et dérivées physiologiques possibles. Trab Inst Cajal 1923; 21: 169–256.Google Scholar
  5. 5.
    Altman J, Anderson WJ. Experimental reorganization of the cerebellar cortex. I. Morphological effects of elimination of the microneurons with prolonged X-irradiation started at birth. J Comp Neurol 1972; 146: 355–406.PubMedCrossRefGoogle Scholar
  6. 6.
    Chan-Palay V. Arrested granule cells and their synapses with mossy fibers in the molecular layer of the cerebellar cortex. Z Anat Entwicklungsgesch 1972; 139: 11–20.PubMedGoogle Scholar
  7. 7.
    Stoughton R., del Cerro M, Walker J., Swarz JR. Presence of displaced neural elements within rat cerebellar fissures. Brain Res 1978; 148: 15–29.PubMedCrossRefGoogle Scholar
  8. 8.
    Altman J. Morphological development of the rat cerebellum and some of its mechanisms. In: Palay S., Chan-Palay V, editors. The cerebellum-new vistas. Berlin, Heidelberg, New York: Springer-Verlag, 1982: 8–49.Google Scholar
  9. 9.
    De Camilli P., Miller PE., Levitt P, Walter V, Greengard P. Anatomy of cerebellar Purkinje cells in the rat determined by a specific immunohistochemical marker. Neuroscience 1984; 11: 761–817.PubMedCrossRefGoogle Scholar
  10. 10.
    Mangold U, Sievers J, Berry M. 6-Hydroxydopamine induced ectopia of external granule cells in the subarachnoid space covering the cerebellum. II. Differentiation of granule cells: a scanning and transmission electron microscopic study. J Comp Neurol 1984; 227: 267–284.PubMedCrossRefGoogle Scholar
  11. 11.
    Wassef M, Sotelo C. Asynchrony in the expression of guanosine 3’-5’-phosphate-dependent protein kinase by clusters of Purkinje cells during the perinatal development of rat cerebellum. Neuroscience 1984; 13: 1217–1241.PubMedCrossRefGoogle Scholar
  12. 12.
    Bartolome JV, Schweitzer L, Slotkin TA, Nadler JV. Impaired development of cerebellar cortex in rats treated postnatally with alpha-difluoromethylornithine. Neuroscience 1985; 15: 203–213.PubMedCrossRefGoogle Scholar
  13. 13.
    Lafarga M, Berciano MT. A Golgi and morphometric study of the ectopic granule cells in the molecular layer of the rat cerebellum. Brain Res 1985; 345: 398–401.PubMedCrossRefGoogle Scholar
  14. 14.
    Barry de J, Gombos G, Klupp T, Hamori J. Alteration of mouse cerebellar circuits following methylazoxymethanol treatment during development: immunohistochemistry of GABAergic elements and electron microscopic study. J Comp Neurol 1987; 261: 253–265.PubMedCrossRefGoogle Scholar
  15. 15.
    Berciano MT, Lafarga M. Colony-forming ectopic granule cells in the cerebellar primary fissure of normal adult rats: a morphologic and morphometric study. Brain Res 1988; 439: 169–178.PubMedCrossRefGoogle Scholar
  16. 16.
    Scherini E, Bernocchi G. Ectopic Purkinje-like cells are GABAergic: immunohistochemistry with an immune serum against glutamic acid decarboxylase. Cell Tissue Res 1989; 258: 437–439.PubMedCrossRefGoogle Scholar
  17. 17.
    Berciano MT, Conde B, Lafarga M. Interactions between astroglia and ectopic granule cells in the cerebellar cortex of normal adult rats: a morphological and cytochemical study. Exp Brain Res 1990; 80: 397–408.PubMedCrossRefGoogle Scholar
  18. 18.
    Yamamoto M, Ullman D, Drager UC, McCaffery P. Postnatal effects of retinoic acid on cerebellar development. Neurotoxicol Teratol 1999; 21: 141–146.PubMedCrossRefGoogle Scholar
  19. 19.
    Lafarga M, Berciano MT, Blanco M. Ectopic Purkinje cells in the cerebellar white matter of normal adult rodents: a Golgi study. Acta Anat 1986; 127: 53–58.PubMedCrossRefGoogle Scholar
  20. 20.
    Griffin WST, Head JR, Woodward DJ, Carrol C. Graft versus host disease impairs cerebellar growth. Nature 1978; 275: 315–317.PubMedCrossRefGoogle Scholar
  21. 21.
    Griffin WST, Head JR, Pacheco MF. Cerebellar morphology: alterations during graft versus host disease. Brain Res Bull 1979; 4: 313–317.PubMedCrossRefGoogle Scholar
  22. 22.
    Ezerman EB, Kromer LF. Outbred Sprague-Dawley rats from two breeders exhibit different incidences of neuroanatomical abnormalities affecting the primary cerebellar fissure. Exp Brain Res 1985; 59: 625–628.PubMedCrossRefGoogle Scholar
  23. 23.
    Griffin WST, Eriksson MA., Del Cerro M, Woodward DJ, Stampfer N. Naturally occurring alterations of cortical layers surrounding the fissura prima of rat cerebellum. J Comp Neurol 1980; 192: 109–118.PubMedCrossRefGoogle Scholar
  24. 24.
    Necchi D, Soldani C, Bernocchi G, Scherini E. Development of the anatomical alteration of the cerebellar fissura prima. Anat Rec 2000; 259: 150–156.PubMedCrossRefGoogle Scholar
  25. 25.
    Pehlemann FW, Sievers J, Berry M. Meningeal cells are involved in foliation, lamination and neurogenesis of the cerebellum: evidence from 6-hydroxydopamine-induced destruction of meningeal cells. Dev Biol 1985; 110: 136–146.PubMedCrossRefGoogle Scholar
  26. 26.
    Lyon G, Raymond G, Mogami K, Gadisseux JF, Della Giustina E. Disorder of cerebellar foliation in Walker’s lissencephaly and neu-laxova syndrome. J Neuropathol Exp Neurol 1993; 52: 633–639.PubMedCrossRefGoogle Scholar
  27. 27.
    Scherini E. Permanent alterations of the dendritic tree of cerebellar Purkinje neurons in the rat following postnatal exposure to cis-dichlorodiammineplatinum. Acta Neuropathol 1991; 81: 324–327.PubMedCrossRefGoogle Scholar

Copyright information

© Springer 2002

Authors and Affiliations

  1. 1.Dipartimento di Biologia Animale, Laboratorio di Biologia CellulareUniversità di Pavia and Centro di Studio per l’IstochimicaCNR, PaviaItaly

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