Journal of NeuroVirology

, Volume 14, Issue 6, pp 465–473

NeuroAIDS in the Asia Pacific Region

  • Edwina J. Wright
  • Michael Nunn
  • Jeymohan Joseph
  • Kevin Robertson
  • Luxshimi Lal
  • Bruce J. Brew


Over 8.3 million people living in the Asia Pacific region are human immunodeficiency virus (HIV) positive and up to 40% of these individuals have had prior acquired immunodeficiency syndrome (AIDS) illnesses. Recently endeavors have been made to better characterize the burden of HIV-related neurological disease within the Asia Pacific region and, with this in mind, the NeuroAIDS in Asia and the Pacific Rim workshop was held in Sydney, Australia, as an affiliated event of the 4th IAS Conference on HIV Pathogenesis, Treatment and Prevention. The workshop was supported by the National Institute of Neurological Disorders and Stroke (NINDS) and the National Institute of Mental Health (NIMH) of the United States National Institutes of Health and the Australian Government overseas AID program, AusAID. HIV neurologists, infectious disease physicians, pediatricians, psychiatrists, immunologists, virologists, and researchers from 12 countries of the Asia Pacific region (including Australia), the United States, and the United Kingdom attended the meeting. A broad range of topics were addressed, including common HIV neurological disorders, the lack of diagnostic, management, and research infrastructure, central nervous system (CNS) immune restoration disease, pediatric neuroAIDS, and current clinical and laboratory research projects being undertaken within the Asia Pacific region.


Asia Pacific Clade neuroAIDS HAD HIV host genotype 


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  1. Cherry CL, McArthur JC, Hoy JF, Wesselingh SL (2003). Nucleoside analogues and neuropathy in the era of HAART. J Clin Virol 26: 195–207.PubMedCrossRefGoogle Scholar
  2. Cherry CL, Rosenow A, Affandi JS, McArthur JC, Wesselingh SL, Price P (2008). Cytokine genotype suggests a role for inflammation in nucleoside analog-associated sensory neuropathy (NRTI-SN) and PREDICTS AN INDividual’s NRTI-SN risk. AIDS Res Hum Retro-viruses 24: 117–123.CrossRefGoogle Scholar
  3. Cherry CL, Skolasky RL, Lal L, Creighton J, Hauer P, Raman SP, Moore R, Carter K, Thomas D, Ebenezer GJ, Wesselingh SL, McArthur JC (2006). Antiretroviral use and other risks for HIV-associated neuropathies in an international cohort. Neurology 66: 867–873.PubMedCrossRefGoogle Scholar
  4. Chitsike I, van Furth R (1999). Paralytic poliomyelitis associated with live oral poliomyelitis vaccine in child with HIV infection in Zimbabwe: case report. BMJ 318: 841–843.PubMedGoogle Scholar
  5. Cysique LA, Jin H, Franklin DR Jr, Morgan EE, Shi C, Yu X, Wu Z, Taylor MJ, Marcotte TD, Letendre S, Ake C, Grant I, Heaton RK (2007). Neurobehavioral effects of HIV-1 infection in China and the United States: a pilot study. J Int Neuropsychol Soc 13: 781–790.PubMedGoogle Scholar
  6. De Wit S, Sabin CA, Weber R, Worm SW, Reiss P, Cazanave C, El-Sadr W, Monforte AD, Fontas E, Law MG, Friis-Moller N, Lundgren JD (2008). Incidence and risk factors for new onset diabetes mellitus in HIV infected patients: the D:A:D study. Diabetes Care 31: 1267–1268.CrossRefGoogle Scholar
  7. Dolan MJ, Kulkarni H, Camargo JF, He W, Smith A, Anaya JM, Miura T, Hecht FM, Mamtani M, Pereyra F, Marconi V, Mangano A, Sen L, Bologna R, Clark RA, Anderson SA, Delmar J, O’Connell RJ, Lloyd A, Martin J, Ahuja SS, Agan BK, Walker BD, Deeks SG, Ahuja SK (2007). CCL3L1 and CCR5 influence cell-mediated immunity and affect HIV-AIDS pathogenesis via viral entry-independent mechanisms. Nat Immunol 8: 1324–1336.PubMedCrossRefGoogle Scholar
  8. Duiculescu D, Major EO, Vinters HV, Ungureanu E, Barcau M, Ene L, Zamfirescu A, Ciprut T, Ionescu P, Calistru P, Achim CL (2005). An unusual cluster of epilepsia partialis continua in a pediatric AIDS cohort. In: HIV Infection and the Central Nervous System: Developed and Resource limited Settings Conference, Frascati (Rome), Italy. June 11–13.Google Scholar
  9. Friis-Moller N, Reiss P, Sabin CA, Weber R, Monforte A, El-Sadr W, Thiebaut R, De Wit S, Kirk O, Fontas E, Law MG, Phillips A, Lundgren JD (2007). Class of antiretroviral drugs and the risk of myocardial infarction. N Engl J Med 356: 1723–1735.PubMedCrossRefGoogle Scholar
  10. Friis-Moller N, Sabin CA, Weber R, d’Arminio Monforte A, El-Sadr WM, Reiss P, Thiebaut R, Morfeldt L, De Wit S, Pradier C, Calvo G, Law MG, Kirk O, Phillips AN, Lundgren JD (2003a). Combination antiretroviral therapy and the risk of myocardial infarction. N Engl J Med 349: 1993–2003.PubMedCrossRefGoogle Scholar
  11. Friis-Moller N, Weber R, Reiss P, Thiebaut R, Kirk O, d’Arminio Monforte A, Pradier C, Morfeldt L, Mateu S, Law M, El-Sadr W, De Wit S, Sabin CA, Phillips AN, Lundgren JD (2003b). Cardiovascular disease risk factors in HIV patients—association with antiretroviral therapy. Results from the DAD study. AIDS 17: 1179–1193.PubMedCrossRefGoogle Scholar
  12. Gatanaga H, Hayashida T, Tsuchiya K, Yoshino M, Kuwahara T, Tsukada H, Fujimoto K, Sato I, Ueda M, Horiba M, Hamaguchi M, Yamamoto M, Takata N, Kimura A, Koike T, Gejyo F, Matsushita S, Shirasaka T, Kimura S, Oka S (2007). Successful efavirenz dose reduction in HIV type 1-infected individuals with cytochrome P450 2B6 *6 and *26. Clin Infect Dis 45: 1230–1237.PubMedCrossRefGoogle Scholar
  13. Gonzalez E, Kulkarni H, Bolivar H, Mangano A, Sanchez R, Catano G, Nibbs RJ, Freedman BI, Quinones MP, Bamshad MJ, Murthy KK, Rovin BH, Bradley W, Clark RA, Anderson SA, O’Connell RJ, Agan BK, Ahuja SS, Bologna R, Sen L, Dolan MJ, Ahuja SK (2005). The influence of CCL3L1 gene-containing segmental duplications on HIV-1/AIDS susceptibility. Science 307: 1434–1440.PubMedCrossRefGoogle Scholar
  14. Gonzalez E, Rovin BH, Sen L, Cooke G, Dhanda R, Mummidi S, Kulkarni H, Bamshad MJ, Telles V, Anderson SA, Walter EA, Stephan KT, Deucher M, Mangano A, Bologna R, Ahuja SS, Dolan MJ, Ahuja SK (2002). HIV-1 infection and AIDS dementia are influenced by a mutant MCP-1 allele linked to increased monocyte infiltration of tissues and MCP-1 levels. Proc Natl Acad Sci U S A 99: 13795–13800.PubMedCrossRefGoogle Scholar
  15. Gouandjika-Vasilache I, Akoua-Koffi C, Begaud E, Dosseh A (2005). No evidence of prolonged enterovirus excretion in HIV-seropositive patients. Trop Med Int Health 10: 743–747.PubMedCrossRefGoogle Scholar
  16. Grimwade K, French N, Mbatha DD, Zungu DD, Dedicoat M, Gilks CF (2004). HIV infection as a cofactor for severe falciparum malaria in adults living in a region of unstable malaria transmission in South Africa. AIDS 18: 547–554.PubMedCrossRefGoogle Scholar
  17. Gupta JD, Satishchandra P, Gopukumar K, Wilkie F, Waldrop-Valverde D, Ellis R, Ownby R, Subbakrishna DK, Desai A, Kamat A, Ravi V, Rao BS, Satish KS, Kumar M (2007). Neuropsychological deficits in human immunodeficiency virus type 1 clade C-seropositive adults from South India. J NeuroVirol 13: 195–202.PubMedCrossRefGoogle Scholar
  18. Gwer S, Newton CR, Berkley JA (2007). Over-diagnosis and co-morbidity of severe malaria in African children: a guide for clinicians. Am J Trop Med Hyg 77: 6–13.PubMedGoogle Scholar
  19. Haas DW, Ribaudo HJ, Kim RB, Tierney C, Wilkinson GR, Gulick RM, Clifford DB, Hulgan T, Marzolini C, Acosta EP (2004). Pharmacogenetics of efavirenz and central nervous system side effects: an Adult AIDS Clinical Trials Group study. AIDS 18: 2391–2400.PubMedGoogle Scholar
  20. Hennessey KA, Lago H, Diomande F, Akoua-Koffi C, Caceres VM, Pallansch MA, Kew OM, Nolan M, Zuber PL (2005). Poliovirus vaccine shedding among persons with HIV in Abidjan, Cote d’Ivoire. J Infect Dis 192: 2124–2128.PubMedCrossRefGoogle Scholar
  21. Jamison SC, Michaels SR, Ratard R, Sweet JM, Deboisblanc BP (2007). A 41-year-old HIV-positive man with acute onset of quadriplegia after West Nile virus infection. South Med J 100: 1051–1053.PubMedGoogle Scholar
  22. Mishra M, Vetrivel S, Siddappa NB, Ranga U, Seth P (2007). Clade-specific differences in neurotoxicity of human immunodeficiency virus-1 B and C Tat of human neurons: significance of dicysteine C30C31 motif. Ann Neurol 63: 366–376.CrossRefGoogle Scholar
  23. Moss WJ, Fisher C, Scott S, Monze M, Ryon JJ, Quinn TC, Griffin DE, Cutts FT (2008). HIV type 1 infection is a risk factor for mortality in hospitalized Zambian children with measles. Clin Infect Dis 46: 523–527.PubMedCrossRefGoogle Scholar
  24. Neogi DK, Bhattacharya N, Chakrabarti T, Mukherjee KK (1998). Detection of HIV seropositivity during an outbreak of Japanese encephalitis in Manipur. J Commun Dis 30: 113–116.PubMedGoogle Scholar
  25. Newton CR (2005). Interaction between Plasmodium falciparum and human immunodeficiency virus type 1 on the central nervous system of African children. J NeuroVirol 11 Suppl 3: 45–51.PubMedCrossRefGoogle Scholar
  26. Oelrichs R (2004). The subtypes of human immunodeficiency virus in Australia and Asia. Sex Health 1: 1–11.PubMedCrossRefGoogle Scholar
  27. Pavlov DN, Van Zyl WB, Kruger M, Blignaut L, Grabow WO, Ehlers MM (2006a). Poliovirus vaccine strains detected in stool specimens of immunodeficient children in South Africa. Diagn Microbiol Infect Dis 54: 23–30.PubMedCrossRefGoogle Scholar
  28. Pavlov DN, Van Zyl WB, Van Heerden J, Kruger M, Blignaut L, Grabow WO, Ehlers MM (2006b). Prevalence of vaccine-derived polioviruses in stools of immunodeficient children in South Africa. J Appl Microbiol 101: 1367–1379.PubMedCrossRefGoogle Scholar
  29. Ranga U, Shankarappa R, Siddappa NB, Ramakrishna L, Nagendran R, Mahalingam M, Mahadevan A, Jayasuryan N, Satishchandra P, Shankar SK, Prasad VR (2004). Tat protein of human immunodeficiency virus type 1 subtype C strains is a defective chemokine. J Virol 78: 2586–2590.PubMedCrossRefGoogle Scholar
  30. Ryan CE, Gare J, Crowe SM, Wilson K, Reeder JC, Oelrichs RB (2007). The heterosexual HIV type 1 epidemic in Papua New Guinea is dominated by subtype C. AIDS Res Hum Retroviruses 23: 941–944.PubMedCrossRefGoogle Scholar
  31. Schwartz L, Civitello L, Dunn-Pirio A, Ryschkewitsch S, Berry E, Cavert W, Kinzel N, Lawrence DM, Hazra R, Major EO (2007). Evidence of human immunodeficiency virus type 1 infection of nestin-positive neural progenitors in archival pediatric brain tissue. J NeuroVirol 13: 274–283.PubMedCrossRefGoogle Scholar
  32. Schwartz L, Major EO (2006). Neural progenitors and HIV-1-associated central nervous system disease in adults and children. Curr HIV Res 4: 319–327.PubMedCrossRefGoogle Scholar
  33. Shankar SK, Mahadevan A, Satishchandra P, Kumar RU, Yasha TC, Santosh V, Chandramuki A, Ravi V, Nath A (2005). Neuropathology of HIV/AIDS with an overview of the Indian scene. Indian J Med Res 121: 468–488.PubMedGoogle Scholar
  34. Shankar SK, Satishchandra P, Mahadevan A, Yasha TC, Nagaraja D, Taly AB, Prabhakar S, Nath A (2003). Low prevalence of progressive multifocal leukoencephalopathy in India and Africa: is there a biological explanation? J NeuroVirol 9 Suppl 1: 59–67.PubMedGoogle Scholar
  35. Torno M, Vollmer M, Beck CK (2007). West Nile virus infection presenting as acute flaccid paralysis in an HIV-infected patient: a case report and review of the literature. Neurology 68: E5-E7.PubMedCrossRefGoogle Scholar
  36. Valcour VG, Sithinamsuwan P, Nidhinandana S, Thitivichianlert S, Ratto-Kim S, Apateerapong W, Shiramizu BT, Desouza MS, Chitpatima ST, Watt G, Chuenchitra T, Robertson KR, Paul RH, McArthur JC, Kim JH, Shikuma CM (2007). Neuropsychological abnormalities in patients with dementia in CRF 01_AE HIV-1 infection. Neurology 68: 525–527.PubMedCrossRefGoogle Scholar
  37. Van Rie A, Harrington PR, Dow A, Robertson K (2007). Neurologic and neurodevelopmental manifestations of pediatric HIV/AIDS: a global perspective. Eur J Paediatr Neurol 11: 1–9.PubMedGoogle Scholar
  38. Walker M, Kublin JG, Zunt JR (2006). Parasitic central nervous system infections in immunocompromised hosts: malaria, microsporidiosis, leishmaniasis, and African trypanosomiasis. Clin Infect Dis 42: 115–125.PubMedCrossRefGoogle Scholar
  39. Wright E, Brew B, Arayawichanont A, Robertson K, Samintharapanya K, Kongsaengdao S, Lim M, Vonthanak S, Lal L, Sarim C, Huffam S, Li P, Imran D, Lewis J, Lun WH, Kamarulzaman A, Tau G, Ali ST, Kishore K, Bain MP, Dwyer R, McCormack G, Hellard M, Cherry C, McArthur J, Wesselingh S (2008). Neurologic disorders are prevalent in HIV-positive outpatients in the Asia-Pacific region. Neurology 71: 50–56.PubMedCrossRefGoogle Scholar
  40. Wright E.J, Brew BJ, Arayawichanont A, Samintharapanya K, Kongsaengdao S, Lal L, Lewis J, Imran D, Robertson K, Saphonn V, Sarim C, Huffam SE, Li P, Lim M, Lun WH, Kamarulzaman A, Tau G, Ty Ali S, Kishore K, Bain M, Dwyer R, McCormack G, Hellard ME, Cherry CL, McArthur JC, Wesselingh SL (2007). High burden of neurological disease in HIV positive inpatients within the Asia Pacific (AP) region: the APNAC Study. Abstract MOPEB078. In: 4th International AIDS Society Conference, July 22–25. Sydney, Australia.Google Scholar
  41. Zhou J, Kumarasamy N, Ditangco R, Kamarulzaman A, Lee CK, Li PC, Paton NI, Phanuphak P, Pujari S, Vibhagool A, Wong WW, Zhang F, Chuah J, Frost KR, Cooper DA, Law MG (2005). The TREAT Asia HIV Observational Database: baseline and retrospective data. J Acquir Immune Defic Syndr 38: 174–179.PubMedCrossRefGoogle Scholar

Copyright information

© Journal of NeuroVirology, Inc. 2008

Authors and Affiliations

  • Edwina J. Wright
    • 1
    • 2
    • 3
  • Michael Nunn
    • 4
  • Jeymohan Joseph
    • 5
  • Kevin Robertson
    • 6
  • Luxshimi Lal
    • 2
    • 3
  • Bruce J. Brew
    • 7
    • 8
  1. 1.Department of Infectious DiseasesThe Alfred HospitalMelbourneAustralia
  2. 2.Department of NeurovirologyBurnet InstituteMelbourneAustralia
  3. 3.Department of MedicineMonash UniversityClaytonAustralia
  4. 4.Grants DevelopmentSalk InstituteSan DiegoUSA
  5. 5.National Institute of Mental Health (NIMH), National Institutes of HealthBethesdaUSA
  6. 6.Department of NeurologyUniversity of North Carolina at Chapel HillChapel HillUSA
  7. 7.Department of NeurologySt Vincent’s HospitalSydneyAustralia
  8. 8.Department of MedicineUniversity of New South WalesSydneyAustralia

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