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Journal of NeuroVirology

, Volume 14, Issue 2, pp 130–135 | Cite as

Significantly increased antibody response to heterogeneous nuclear ribonucleoproteins in cerebrospinal fluid of multiple sclerosis patients but not in patients with human T-lymphotropic virus type I—associated myelopathy/tropical spastic paraparesis

  • Motohiro Yukitake
  • Eisaburo Sueoka
  • Naoko Sueoka-Aragane
  • Akemi Sato
  • Hiromi Ohashi
  • Yusuke Yakushiji
  • Mineki Saito
  • Mitsuhiro Osame
  • Shuji Izumo
  • Yasuo Kuroda
Article

Abstract

It has been reported that antibodies (Abs) against heterogeneous nuclear ribonucleoproteins (hnRNPs) are associated with human T-lymphotropic virus type I (HTLV-I)—associated myelopathy/tropical spastic paraparesis (HAM/TSP) and multiple sclerosis (MS). However, these studies were done under nonmasked conditions. In order to determine whether Abs against hnRNPs associate with HAM/TSP and MS, the authors assayed Abs against two major hnRNPs, hnRNP A1 and A2/B1, in 105 cerebrospinal fluid (CSF) samples under fully masked conditions. Samples included 40 cases of HAM/TSP, 28 of MS, and 37 of other neurological diseases. Anti-hnRNP A1 Abs, and especially anti-hnRNP A2/B1 Abs, were found significantly more often in the CSF of MS patients than in other groups. However, there was no difference in the incidence of anti-hnRNP A1 Abs between HAM/TSP and other disease groups.

Keywords

anti-hnRNP A1 antibody anti-hnRNP A2/B1 antibody cerebrospinal fluid HTLV-I—associated myelopathy/tropical spastic paraparesis multiple sclerosis 

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Copyright information

© Journal of NeuroVirology, Inc. 2008

Authors and Affiliations

  • Motohiro Yukitake
    • 1
  • Eisaburo Sueoka
    • 1
  • Naoko Sueoka-Aragane
    • 1
  • Akemi Sato
    • 1
  • Hiromi Ohashi
    • 1
  • Yusuke Yakushiji
    • 1
  • Mineki Saito
    • 2
  • Mitsuhiro Osame
    • 3
  • Shuji Izumo
    • 4
  • Yasuo Kuroda
    • 1
  1. 1.Department of Internal Medicine, Faculty of MedicineSaga UniversitySagaJapan
  2. 2.Department of MicrobiologyKanazawa Medical UniversityIshikawaJapan
  3. 3.Department of Neurology and GeriatricsKagoshima University Graduate School of Medical and Dental SciencesKagoshimaJapan
  4. 4.Division of Molecular Pathology of Center for Chronic Viral DiseasesKagoshima University Graduate School of Medical and Dental SciencesKagoshimaJapan

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