Journal of NeuroVirology

, Volume 13, Issue 5, pp 477–481 | Cite as

Herpes simplex encephalitis presenting with exclusively frontal lobe involvement

  • Sean W. Taylor
  • Donald H. Lee
  • Alan C. Jackson
Case Report


The authors report a patient with herpes simplex encephalitis who presented with magnetic resonance imaging (MRI) lesions exclusively in the frontal lobes, including the bilateral anterior cingulate gyri. She is making a good recovery after therapy with intravenous acyclovir. A similar presentation with a fatal outcome was previously reported by Rose et al (Neurology 42: 1809–1812, 1992). MRI shows temporal lesions in most patients with herpes simplex encephalitis, whereas occasional patients have normal imaging. A high index of suspicion for the diagnosis of herpes simplex encephalitis should be maintained when a patient presents with fever and brain lesions involving extratemporal limbic system structures.


cingulate gyrus encephalitis frontal lobe herpes simplex virus 


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Copyright information

© Journal of NeuroVirology, Inc. 2007

Authors and Affiliations

  • Sean W. Taylor
    • 1
  • Donald H. Lee
    • 2
  • Alan C. Jackson
    • 1
    • 3
  1. 1.Department of Medicine (Neurology)Queen’s UniversityKingstonCanada
  2. 2.Departments of Radiology and Nuclear MedicineUniversity of Western OntarioLondonCanada
  3. 3.Health Sciences Centre, GF543WinnipegCanada

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