Journal of NeuroVirology

, Volume 12, Issue 2, pp 140–145

Dopaminergic marker proteins in the substantia nigra of human immunodeficiency virus type 1-infected brains

  • Janelle M. Silvers
  • Michael Y. Aksenov
  • Marina V. Aksenova
  • Jacob Beckley
  • Petra Olton
  • Charles F. Mactutus
  • Rosemarie M. Booze
Short Communication

DOI: 10.1080/13550280600724319

Cite this article as:
Silvers, J.M., Aksenov, M.Y., Aksenova, M.V. et al. Journal of NeuroVirology (2006) 12: 140. doi:10.1080/13550280600724319

Abstract

With the advent of highly active antiretroviral therapy, human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) is becoming a more chronic, manageable disease; nevertheless, the prevalence of neurological complications of AIDS is increasing. In this study, protein levels of tyrosine hydroxylase (TH) and dopamine transporter (DAT) in the substantia nigra of HIV-infected brains and -seronegative controls were determined by immunoblotting. The immunoreactivity of neuronal specific enolase (NSE) was used to assess cell loss. Although there were no changes in levels of immunoreactive DAT or NSE proteins in HIV brains, levels of immunoreactive TH were significantly reduced, relative to controls. These results suggest that decreases in TH, the rate-limiting enzyme of dopamine synthesis, may be a factor in the neurological manifestations of HIV infection.

Keywords

dopamine transporter HIV-associated dementia neuroAIDS tyrosine hydroxylase 

Copyright information

© Journal of NeuroVirology, Inc. 2006

Authors and Affiliations

  • Janelle M. Silvers
    • 1
  • Michael Y. Aksenov
    • 1
  • Marina V. Aksenova
    • 1
  • Jacob Beckley
    • 1
  • Petra Olton
    • 1
  • Charles F. Mactutus
    • 1
  • Rosemarie M. Booze
    • 1
    • 2
  1. 1.Program in Behavioral NeuroscienceUniversity of South CarolinaColumbiaUSA
  2. 2.Departments of Psychology, Physiology and PharmacologyUniversity of South CarolinaColumbiaUSA

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