Journal of NeuroVirology

, Volume 12, Issue 1, pp 65–71 | Cite as

Regulation of human endogenous retrovirus W protein expression by herpes simplex virus type 1: Implications for multiple sclerosis

  • Klemens RuprechtEmail author
  • Karola Obojes
  • Verena Wengel
  • Felix Gronen
  • Kwang Sik Kim
  • Hervé Perron
  • Jürgen Schneider-Schaulies
  • Peter Rieckmann
Short Communication


The multiple sclerosis-associated retrovirus (MSRV), originally identified in cell cultures from patients with multiple sclerosis (MS), is closely related to the human endogenous retrovirus family W (HERV-W). Recently, HERV-W gag and env protein expression was demonstrated in MS lesions in situ. Here, the authors show that HERV-W gag and env proteins are induced by herpes simplex virus type 1 (HSV-1) in neuronal and brain endothelial cells in vitro. The transactivation of HERV-W proteins by HSV-1 could enhance their potential oligodendrotoxic and immunopathogenic effects, representing a mechanism by which HSV-1, and possibly also other herpesviruses associated with MS, may be linked to the pathogenesis of this disease.


cerebral endothelial cells herpes simplex virus type 1 human endogenous retrovirus W IMR-32 multiple sclerosis 


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Copyright information

© Journal of NeuroVirology, Inc. 2006

Authors and Affiliations

  • Klemens Ruprecht
    • 1
    • 5
    Email author
  • Karola Obojes
    • 1
    • 2
  • Verena Wengel
    • 1
  • Felix Gronen
    • 1
  • Kwang Sik Kim
    • 3
  • Hervé Perron
    • 4
  • Jürgen Schneider-Schaulies
    • 2
  • Peter Rieckmann
    • 1
  1. 1.Clinical Research Unit for Multiple Sclerosis and Neuroimmunology, Department of NeurologyJulius-Maximilians UniversityWürzburgGermany
  2. 2.Institute for Virology and ImmunobiologyJulius-Maximilians UniversityWürzburgGermany
  3. 3.Department of PediatricsJohns Hopkins University School of MedicineBaltimoreUSA
  4. 4.R&DbioMérieuxMarcy L’EtoileFrance
  5. 5.Department of PsychiatryJulius-Maximilians UniversityWürzburgGermany

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