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Journal of NeuroVirology

, Volume 11, Issue 1, pp 88–92 | Cite as

The role of immune responses in the pathogenesis of rabies

  • D. Craig HooperEmail author
Mini-Review—The Rabies Virus

Abstract

In the absence of treatment, infection with a variety of rabies virus strains most often results in a lethal outcome. This can be averted by prompt immunization following exposure demonstrating that the development of anti-rabies viral immunity prior to extensive infection of neurons is protective. Otherwise it might be expected that immune clearance of the virus would result in neurological sequelae. Thus, the capacity of a rabies virus to induce a protective immune response is a major, negative determinant of its pathogenicity and highly pathogenic rabies viruses have characteristics that avoid triggering protective immune responses. On the other hand, there is evidence that certain aspects of immunity may contribute to the pathogenesis of rabies under certain circumstances. The relationship between rabies virus and the immune system of the host is the focus of this review.

Keywords

immunology immunopathology rabies virus 

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References

  1. Astoul E, Lafage M, Lafon M (1996). Rabies superantigen as a V beta T-dependent adjuvant. J Exp Med 183: 1623–1631.CrossRefPubMedGoogle Scholar
  2. Baloul L, Lafon M (2003). Apoptosis and rabies virus neuroinvasion. Biochimie 85: 777–788.CrossRefPubMedGoogle Scholar
  3. Camelo S, Lafage M, Galelli A, Lafon M (2001). Selective role for the p55 TNF-α receptor in immune unresponsiveness induced by an acute viral encephalitis. J Neuroimmunol 113: 95–108.CrossRefPubMedGoogle Scholar
  4. Camelo S, Lafage M, Lafon M (2000). Absence of the p55 TNF-α receptor promotes survival in rabies acute viral encephalitis. J NeuroVirol 6: 507–518.CrossRefPubMedGoogle Scholar
  5. CDC (2004). Investigation of rabies infections in organ donor and transplant recipients—Alabama, Arkansas, Oklahoma, and Texas, 2004. MMWR Morb Mort Wkly Rep 53(Dispatch): 1–3.Google Scholar
  6. Faber M, Pulmanausahakul R, Hodawadekar SS, Spitsin S, McGettigan JP, Schnell MJ, Dietzschold B (2002). Overexpression of the rabies virus glycoprotein results in enhancement of apoptosis and antiviral immune response. J Virol 76: 3374–3381.CrossRefPubMedGoogle Scholar
  7. Galelli A, Baloul L, Lafon M (2000). Abortive rabies virus central nervous infection is controlled by T lymphocyte local recruitment and induction of apoptosis. J NeuroVirol 6: 359–372.CrossRefPubMedGoogle Scholar
  8. Gremliza L (1953). Casuistic to the rabies problem. Z Tropenmed Parasitol 4: 382–389.PubMedGoogle Scholar
  9. Hirai K, Kawano H, Mifune K, Fujii H, Nishizono A, Shichijo A, Mannen K (1992). Suppression of cell-mediated immunity by street rabies virus infection. Microbiol Immunol 36: 1277–1290.PubMedGoogle Scholar
  10. Hooper DC, Morimoto K, Bette M, Weihe M, Koprowski H, Dietzschold B (1998). Collaboration of antibody and inflammation in the clearance of rabies virus from the CNS. J Virol, 72: 3711–3719.PubMedGoogle Scholar
  11. Hooper DC, Ohnishi ST, Kean R, Numagami Y, Dietzschold B, Koprowski H (1995). Local nitric oxide production in viral and autoimmune diseases of the central nervous system. Proc Natl Acad Sci U S A 92: 5312–5316.CrossRefPubMedGoogle Scholar
  12. Irwin DJ, Wunner WH, Ertl HC, Jackson AC (1999). Basis of rabies virus neurovirulence in mice: expression of major histocompatibility complex class I and class II mRNAs. J NeuroVirol 5: 485–494.CrossRefPubMedGoogle Scholar
  13. Iwasaki Y, Gerhard W, Clark HF (1977). Role of host immune response in the development of either encephalitic or paralytic disease after experimental rabies infection in mice. Infect Immun 18: 220–225.PubMedGoogle Scholar
  14. Kaplan MM, Wiktor TJ, Koprowski H (1975). Pathogenesis of rabies in immunodeficient mice. J Immunol 114: 1761–1765.PubMedGoogle Scholar
  15. Kean RB, Spitsin SV, Mikheeva T, Scott GS, Hooper DC (2000). The peroxynitrite scavenger uric acid prevents inflammatory cell invasion into the CNS in experimental allergic encephalomyelitis through maintenance of blood-CNS barrier integrity. J Immunol 165: 6511–6518.PubMedGoogle Scholar
  16. Morimoto K, Hooper DC, Carbaugh H, Fu ZF, Koprowski H, Dietzschold B (1998). Rabies virus quasispecies: implications for pathogenesis. Proc Natl Acad Sci U S A 95: 3152–3156.CrossRefPubMedGoogle Scholar
  17. Morimoto K, Hooper DC, Spitsin S, Koprowski H, Dietzschold B (1999). Pathogenicity of different rabies virus variants inversely correlates with apoptosis and rabies virus glycoprotein expression in infected primary neuron cultures. J Virol 73: 510–518.PubMedGoogle Scholar
  18. Morimoto K, Patel M, Corisdeo S, Hooper DC, Fu ZF, Rupprecht CE, Koprowski H, Dietzschold B (1996). Characterization of a unique variant of rabies virus carried by silver-haired bats which is responsible for a newly emerging form of human rabies in North America. Proc Natl Acad Sci U S A 93: 5653–5658.CrossRefPubMedGoogle Scholar
  19. Piyasirisilp S, Schmeckpeper BJ, Chandanayingyong D, Hemachuda T, Griffin DE (1999). Association of HLA and T-cell receptor gene polymorphisms with semple rabies vaccine-induced autoimmune encephalomyelitis. Ann Neurol 45: 595–600.CrossRefPubMedGoogle Scholar
  20. Prabhakar BS, Nathanson N (1981). Acute rabies death mediated by antibody. Nature 290: 590–591.CrossRefPubMedGoogle Scholar
  21. Prehaud C, Lay S, Dietzschold B, Lafon M (2003). Glycoprotein of nonpathogenic rabies viruses is a key determinant of human cell apoptosis. J Virol 77: 10537–10547.CrossRefPubMedGoogle Scholar
  22. Prosniak M, Hooper DC, Dietzschold B, Koprowski H (2001). Effect of rabies virus infection on gene expression in mouse brain. Proc Natl Acad Sci U S A 98: 2758–2763.CrossRefPubMedGoogle Scholar
  23. Pulmanausahakul R, Faber M, Morimoto K, Spitsin S, Weihe E, Hooper DC, Schnell MJ, Dietzschold B (2002). Overexpression of cytochrome c by a rabies recombinant virus attenuates pathogenicity and enhances antiviral immunity. J Virol 75: 10800–10807.CrossRefGoogle Scholar
  24. Ray NB, Ewalt LC, Lodmell DL (1995). Rabies virus replication in primary murine bone marrow macrophages and in human and murine macrophage-like cell lines: implications for viral persistence. J Virol 69: 764–772.PubMedGoogle Scholar
  25. Smith JS, McCelland CL, Reid FL, Baer GM (1982). Dual role of the immune response in street rabies virus infection of mice. Infect Immun 35: 213–221.PubMedGoogle Scholar
  26. Sugamata M, Miyazawa M, Mori S, Spangrude GJ, Ewalt LC, Lodmell DL (1992). Paralysis of street rabies virus-infected mice is dependent on T lymphocytes. J Virol 66: 1252–1260.PubMedGoogle Scholar
  27. Thoulouze MI, Lafage M, Montano-Hirose JA, Lafon M (1997). Rabies virus infects mouse and human lymphocytes and induces apoptosis. J Virol 71: 7372–7380.PubMedGoogle Scholar
  28. Thoulouze M-I, Lafage M, Yuste VJ, Baloul L, Edelman L, Kroemer G, Israel N, Susin SA, Lafon M (2003). High level of Bcl-2 counteracts apoptosis mediated by a live rabies virus vaccine strain and induces long-term infection. Virology 314: 549–561.CrossRefPubMedGoogle Scholar
  29. Wiktor TJ, Doherty PC, Koprowski H (1977). Suppression of cell-mediated immunity by street rabies virus. J Exp Med 145: 1617–1622.CrossRefPubMedGoogle Scholar
  30. Weiland F, Cox JH, Meyer S, Dahme E, Reddehase MJ (1992). Rabies virus neuritic paralysis: immunopathogenesis of nonfatal paralytic rabies. J Virol 66: 5096–5099.PubMedGoogle Scholar
  31. Xan X, Prosniak M, Curtis MT, Weiss ML, Faber M, Deitzschold B, Fu ZF (2001). Silver-haired bat rabies virus variant does not induce apoptosis in the brains of experimentally infected mice. J NeuroVirol 7: 518–527.CrossRefGoogle Scholar
  32. Xiang ZQ, Knowles BB, McCarrick JW, Ertl HC (1995). Immune effector mechanisms required for protection to rabies virus. Virology 214: 398–404.CrossRefPubMedGoogle Scholar

Copyright information

© Journal of NeuroVirology, Inc. 2005

Authors and Affiliations

  1. 1.Department of Microbiology and ImmunologyThomas Jefferson UniversityPhiladelphiaUSA

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