Journal of NeuroVirology

, Volume 10, Issue 6, pp 409–413 | Cite as

Neuronal apoptosis in immunodeficient mice infected with the challenge virus standard strain of rabies virus by intracerebral inoculation

  • Maegan Rutherford
  • Alan C. JacksonEmail author
Short Communication


The challenge virus standard-11 strain (CVS) of fixed rabies virus produces neuronal apoptosis in widespread areas of the brain of mice after intracerebral inoculation. The role of the adaptive immune response in producing neuronal apoptosis in this model was evaluated by comparing the infections in adult C57BL/6J mice with nude mice (T cell deficient) and Rag1 mice (T and B cell deficient). Both strains of immunodeficient mice showed very similar clinical disease and neuropathological findings, including marked neuronal apoptosis. The adaptive immune response is unlikely of fundamental importance in producing neuronal apoptosis in the brains of mice in this model.


neuronal apoptosis rabies viral pathogenesis 


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Copyright information

© Journal of NeuroVirology, Inc. 2004

Authors and Affiliations

  1. 1.Department of Microbiology and ImmunologyQueen’s UniversityKingstonCanada
  2. 2.Department of MedicineQueen’s UniversityKingstonCanada
  3. 3.Kingston General HospitalKingstonCanada

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