Journal of NeuroVirology

, Volume 8, Issue 2, pp 69–75

Insights into the role of immune activation in HIV neuropathogenesis

Review

DOI: 10.1080/13550280290049525

Cite this article as:
Gartner, S. & Liu, Y. Journal of NeuroVirology (2002) 8: 69. doi:10.1080/13550280290049525

Abstract

How does HIV infection lead to the development of central nervous system disease? Central to this question is identification of the relative contributions of (1) the virus, (2) its host cells, and (3) secondary or downstream events to the pathological process. These are re-examined in this brief review. Also, a greater appreciation for the role of systemic events in neuroinflammation is emerging, with likely relevance to HIV-associated dementia. We propose here a model for HIV neuropathogenesis that highlights the role of systemic monocyte activation and subsequent neuroinvasion in initiating the disease.

Keywords

HIV brain dementia monocyte microglia 

Copyright information

© Taylor & Francis 2002

Authors and Affiliations

  1. 1.Department of NeurologyThe Johns Hopkins University, School of MedicineBaltimoreUSA

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