Journal of NeuroVirology

, Volume 7, Issue 2, pp 155–162 | Cite as

CD4/CXCR4-independent infection of human astrocytes by a T-tropic strain of HIV-1

  • Becky Schweighardt
  • Joseph T. C. Shieh
  • Walter J. Atwood
Short Communication

Abstract

HIV-1 establishes a low-level persistent infection in astrocytes. In this study, we studied the susceptibility of a human astrocyte cell line (SVG-A) to infection with luciferase expressing reporter viruses pseudotyped with envelopes derived from five isolates of HIV-1. SVG-A cells were susceptible to infection by a T-cell tropic isolate and the infection was both CD4 and CXCR4 independent. These data confirm the susceptibility of astrocytes to infection with T-tropic strains of HIV-1 and suggest a novel mechanism by which T-tropic strains of HIV can infect cells.

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Copyright information

© Journal of NeuroVirology, Inc. 2001

Authors and Affiliations

  • Becky Schweighardt
    • 1
  • Joseph T. C. Shieh
    • 2
  • Walter J. Atwood
    • 1
  1. 1.Department of Molecular Microbiology and ImmunologyBrown UniversityProvidenceUSA
  2. 2.Department of NeurologyUniversity of Pennsylvania Medical CenterPhiladelphiaUSA

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