Inhibition of DT-diaphorase is a requirement for Mn3+ to produce a 6-OH-dopamine like rotational behaviour
- 54 Downloads
Intracerebral managanese administration together with the DT-diaphorase inhibitor dicoumarol (Mn3+ 40 nmol+-dicoumarol 2 nmol; in 4 μl) into the left medial forebrain bundle (MFB) produced a behavioural pattern characterised by contralateral behaviour when the rats were stimulated with apomorphine (0.5 mg/kg s.c.), in a manner similar to that when administered to unilaterally 6-hydroxy-dopamine-lesioned animals. The same animals rotated towards the opposite side (ipsilaterally) when stimulated with d-amphetamine (2 mg/kg s.c.). These results support the idea that DT-diaphorase plays a protective role in the dopaminergic systems.
KeywordsAminochrome Dicoumarol Dopamine 6-OH-dopamine DT-diaphorase Manganese
Unable to display preview. Download preview PDF.
- Naoi, M., Maruyama, W., Dostert, P., Hashizume, Y., Nakahara, D., Takahashi, T. and Ota, M. (1996) “Dopamine-derived endogenous 1 (R), 2 (N)-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, N-methyl-(R)-salsolinol, induced parkinsonism in rat: biochemical, pathological and behavioral studies”, Brain Res. 709, 285–295.PubMedCrossRefGoogle Scholar
- Paris, I., Dagnino-Subiabre, A., Marcelain, K., Bennett, L.B., Caviedes, P., Caviedes, R., Olea Azar, C. and Segura-Aguilar, J. (2001) “Copper neurotoxicity is dependent on dopaminemediated copper uptake and one-electron reduction of aminochrome in rat substantia nigra neuronal cell line”, J. Neurochem. 77, 519–529.PubMedCrossRefGoogle Scholar