Abstract
Background
We assessed the hemodynamic effects of isometric exercise by an ambulatory radionuclide monitoring device (VEST) that measured left ventricular function in patients who had hypertrophic cardiomyopathy (HCM), with and without significant left ventricular outflow-tract obstruction at rest, compared with control subjects.
Methods and Results
We studied 10 patients with obstructive HCM, 25 patients with nonobstructive HCM, and 11 control subjects. During VEST monitoring, all patients gripped a dynamometer at 75% of maximal strength for up to 5 minutes. End-diastolic, end-systolic, and stroke volumes; cardiac output; and systemic vascular resistance were expressed as a percentage of baseline. The mean exercise duration was similar among the 3 groups. During handgrip, heart rate, systolic blood pressure, and cardiac output increased significantly and similarly in the 3 groups. There was a significant difference in the lung activity between obstructive and nonobstructive HCM patients and control subjects (P < .001), with a fall in control subjects and no change in HCM patients, irrespective of obstruction. Control subjects showed a decrease in end-systolic volume (P = .02) and an increase in ejection fraction (P = .003) and stroke volume (P = .009), whereas these parameters did not change in HCM patients, irrespective of obstruction. Systemic vascular resistance increased in obstructive (P = .02) and nonobstructive (P < .01) HCM patients but did not change in control subjects.
Conclusions
Isometric exercise causes an abnormal and similar adaptation to load changes in obstructive and nonobstructive HCM patients, as compared with control subjects. (J Nucl Cardiol 2003;10:154-60.)
Similar content being viewed by others
References
Flamm MD, Harrison DC, Hancock EW. Muscular subaortic stenosis: prevention of outflow obstruction with propranolol. Circulation 1968;38:846–58.
Harrison DC, Braunwald E, Glick G, et al. Effects of beta adrenergic blockade on the circulation, with particular reference to observations in patients with hypertrophic subaortic stenosis. Circulation 1964;29:84–98.
Kluess HA, Wood RH, Welsch MA. Vagal modulation of the heart and central hemodynamics during handgrip exercise. Am J Physiol Heart Circ 2000;279:H1648–52.
Wigle ED, Rakowski H, Kimball BP, Williams WG. Hypertrophic cardiomyopathy. Clinical spectrum and treatment. Circulation 1995;92:1680–92.
Maron BJ, Epstein SE. Hypertrophic cardiomyopathy: a discussion of nomenclature. Am J Cardiol 1979;43:1242–4.
Sahn DJ, DeMaria A, Kisslo J, Weiman A. Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements. Circulation 1978;58: 1072–83.
Spirito P, Maron BJ, Chiarella F, et al. Diastolic abnormalities in patients with hypertrophic cardiomyopathy: relation to magnitude of left ventricular hypertrophy. Circulation 1985;72:310–6.
Helmcke F, Nanda NC, Hsiung MC, et al. Color Doppler assessment of mitral regurgitation with orthogonal planes. Circulation 1987;75:175–83.
Panza JA, Petrone RK, Fananapazir L, Maron BJ. Utility of continuous wave Doppler echocardiography in the noninvasive assessment of left ventricular outflow tract pressure gradient in patients with hypertrophic cardiomyopathy. J Am Coll Cardiol 1991;19:91–9.
Betocchi S, Piscione F, Villari B, et al. Effects of induced asynchrony on left ventricular diastolic function in patients with coronary artery disease. J Am Coll Cardiol 1993;21:1124–31.
Pace L, Cuocolo A, Nappi A, et al. Accuracy and repeatability of left ventricle systolic and diastolic function measurements using an ambulatory radionuclide monitor. Eur J Nucl Med 1992;19:800–6.
Wilson RA, Sullivan PJ, Moore RH, et al. An ambulatory ventricular function monitor: validation and preliminary results. Am J Cardiol 1983;52:601–6.
Asmussen E. Similarities and dissimilarities between static and dynamic exercise. Circ Res 1981;48(Suppl 2):13–20.
Jones RJ, Lahiri A, Cashman PMM, Dore C, Raftery EB. Left ventricular function during isometric handgrip and cold stress in normal subjects. Br Heart J 1986;55:246–52.
Ludbrook PA, Byrne JD, Reed FR, McKnight RC. Modification of left ventricular diastolic behavior by isometric handgrip exercise. Circulation 1980;62:357–70.
Mizushige K, Matsuo H, Nokaki S, Kwan OL, DeMaria AN. Differential responses in left ventricular diastolic filling dynamics with isometric handgrip versus isotonic treadmill exertion. Am Heart J 1996;131:131–7.
Bodenheimer MM, Banka VS, Fooshee CM, Gillespie JA, Helfant RH. Detection of coronary heart disease using radionuclide determined regional ejection fraction at rest and during handgrip exercise: correlation with coronary arteriography. Circulation 1978;4:640–8.
Peter CA, Jones RH. Effects of isometric handgrip and dynamic exercise on left-ventricle function. J Nucl Med 1980;21:1131–8.
Cannon RO III, Rosing DR, Maron BJ, et al. Myocardial ischemia in patients with hypertrophic cardiomyopathy: contribution of inadequate vasodilator reserve and elevated left ventricular filling pressure. Circulation 1985;71:234–43.
Imbriaco M, Cuocolo A, Pace L, et al. Repeatability of hemodynamic responses to cardiac stimulation by ambulatory monitoring of left ventricular function. J Nucl Biol Med 1993;37:238–44.
Dilsizian V, Bonow RO, Epstein SE, Fananapazir L. Myocardial ischemia detected by thallium scintigraphy is frequently related to cardiac arrest and syncope in young patients with hypertrophic cardiomyopathy. J Am Coll Cardiol 1993;22:796–804.
Yamada M, Elliott PM, Kaski JC, et al. Dipyridamole stress thallium-201 perfusion abnormalities in patients with hypertrophic cardiomyopathy. Eur Heart J 1998;19:500–7.
Cuocolo A, Sax FL, Brush JE, et al. Left ventricular hypertrophy and impaired diastolic filling in essential hypertension. Diastolic mechanisms for systolic dysfunction during exercise. Circulation 1990;81:978–86.
Gwathmey JK, Warren SE, Briggs GM, et al. Diastolic dysfunction in hypertrophic cardiomyopathy. Effect on active force generation during systole. J Clin Invest 1991;87:1023–31.
Little WC, Barr WK, Crawford MH. Altered effect of the Valsalva maneuver on left ventricular volume in patients with cardiomyopathy. Circulation 1985;71:227–33.
Wigle ED, Sasson Z, Henderson MA, et al. Hypertrophic cardiomyopathy. The importance of the site and the extent of hypertrophy. A review. Prog Cardiovasc Dis 1985;28:1–83.
Spirito P, Bellone P, Harris KM, et al. Magnitude of left ventricular hypertrophy and risk of sudden death in hypertrophic cardiomyopathy. N Engl J Med 2000;342:1778–85.
Briguori C, Betocchi S, Romano M, et al. Exercise capacity in hypertrophic cardiomyopathy depends on left ventricular diastolic function. Am J Cardiol 1999;84:309–15.
Chigamori T, Counhian PJ, Doi YL, et al. Mechanisms of exercise limitation in hypertrophic cardiomyopathy. J Am Coll Cardiol 1992;19:507–12.
Manganelli F, Betocchi S, Losi MA, et al. Influence of left ventricular cavity size on clinical presentation in hypertrophic cardiomyopathy. Am J Cardiol 1999;83:547–52
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Ciampi, Q., Betocchi, S., Violante, A. et al. Hemodynamic effects of isometric exercise in hypertrophic cardiomyopathy: Comparison with normal subjects. J Nucl Cardiol 10, 154–160 (2003). https://doi.org/10.1067/mnc.2003.9
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1067/mnc.2003.9