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Quantification of myocardial glucose utilization by pet and 1-carbon-11-glucose

  • Original Article
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Journal of Nuclear Cardiology Aims and scope

Abstract

Background

Measurements of the rate of myocardial glucose utilization (rMGU) play a key role in the assessment of alterations in myocardial substrate metabolism in normal and abnormal cardiac states. In this study we determined whether rMGU could be quantified by positron emission tomography (PET) and 1-carbon-11-glucose.

Methods and Results

Twenty dogs were studied with a variety of interventions including fasting (n = 5), hyperinsulinemic-euglycemic clamp at rest (n = 6), clamp and phenylephrine (n = 5), and clamp and dobutamine (n = 4). Measurements of myocardial blood flow and rMGU were made by PET with oxygen-15-water and 1-C-11-glucose, respectively. Arterial-coronary sinus sampling was performed to measure rMGU by the Fick method. Values for rMGU ranged from 50 to 2436 nmol/g/min. Myocardial 1-C-11-glucose images of high quality were obtained. There was a close and direct correlation between values for rMGU measured by PET and those measured directly (y = 0.86x + 112, r = 0.98, P < .0001). The coefficient of variation for the regional estimates of rMGU ranged from 11.3% ± 7.4% during clamp at rest to 16.3% ± 8.4% during clamp with phenylephrine.

Conclusions

It now appears possible to quantify myocardial glucose utilization by PET with 1-C-11-glucose. This method should become a valuable tool in the assessment of alterations in myocardial glucose metabolism in both normal and abnormal myocardium.

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Authors and Affiliations

  1. Cardiovascular Imaging Laboratory, Edward Mallinckrodt Institute of Radiologya, Washington University School of Medicine, 510 S Kingshighway Blvd, 63110, St Louis, Mo

    Pilar Herrero & Robert J. Gropler

  2. Cardiovascular Division, Department of Internal Medicineb, Washington University School of Medicine, St Louis, Mo

    Carla J. Weinheimer, William F. Oellerich & Robert J. Gropler

  3. Division of Radiological Sciences, Edward Mallinckrodt Institute of Radiologyc, Washington University School of Medicine, St Louis, Mo

    Carmen Dence

Authors
  1. Pilar Herrero
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  2. Carla J. Weinheimer
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  3. Carmen Dence
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  4. William F. Oellerich
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  5. Robert J. Gropler
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Corresponding author

Correspondence to Pilar Herrero.

Additional information

This work was supported by NIH grant HL13581.

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Herrero, P., Weinheimer, C.J., Dence, C. et al. Quantification of myocardial glucose utilization by pet and 1-carbon-11-glucose. J Nucl Cardiol 9, 5–14 (2002). https://doi.org/10.1067/mnc.2001.120635

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  • DOI: https://doi.org/10.1067/mnc.2001.120635

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