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Evaluation of left ventricular endocardial volumes and ejection fractions computed from gated perfusion SPECT with magnetic resonance imaging: Comparison of two methods

Journal of Nuclear Cardiology volume 8, pages 645–651 (2001)Cite this article

Abstract

Background

Two methods of computing left ventricular volumes and ejection fraction (EF) from 8-frame gated perfusion single photon emission computed tomography (SPECT) were compared with each other and with magnetic resonance (MR) imaging.

Methods and Results

Thirty-five subjects underwent 8-frame gated dual-isotope SPECT imaging and 12- to 16-frame gated MR imaging. Endocardial boundaries on short-axis MR images were hand traced by experts blinded to any SPECT results. Volumes and EF were computed with the use of Simpson’s rule. SPECT images were analyzed for the same functional variables with the use of 2 automatic programs, Quantitative Gated SPECT (QGS) and the Emory Cardiac Toolbox (ECTb). The mean difference between MR and SPECT EF was 0.008 for ECTb and 0.08 for QGS. QGS showed a slight trend toward higher correlation for EF (r = 0.72, SE of the estimate = 0.08) than ECTb (r = 0.70, SE of the estimate = 0.09). For both SPECT methods, left ventricular volumes were similarly correlated with MR, although SPECT volumes were higher than MR values by approximately 30%.

Conclusions

QGS and ECTb values of cardiac function computed from 8-frame gated perfusion SPECT correlate very well with each other and correlate well with MR. Averaged over all subjects, ECTb measurements of EF are not significantly different from MR values but QGS significantly underestimates the MR values.

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References

  1. Germano G, Kiat H, Kavanagh PB, et al. Automatic quantification of ejection fraction from gated myocardial perfusion SPECT. J Nucl Med 1995;36:2138–47.

    PubMed  CAS  Google Scholar 

  2. Faber TL, Cooke CD, Folks RD, et al. Left ventricular function and perfusion from gated SPECT perfusion images: an integrated method. J Nucl Med 1999;40:650–9.

    PubMed  CAS  Google Scholar 

  3. Berman DS, Germano G, Kiat H, Friedman J. Simultaneous perfusion/function imaging. J Nucl Cardiol 1995;3:271–3.

    Article  Google Scholar 

  4. Germano G, Kavanagh PB, Berman DS. An automatic approach to the analysis, quantitation and review of perfusion and function from myocardial perfusion SPECT images. Int J Card Imaging 1994;13:337–46.

    Article  Google Scholar 

  5. Tadamura E, Kudo T, Motooka M, et al. Assessment of regional and global left ventricular function by reinjection Tl-201 and rest Tc-99m sestamibi ECT-gated SPECT. J Am Coll Cardiol 1999;33:991–7.

    Article  PubMed  CAS  Google Scholar 

  6. Vaduganathan P, Zuo-Xiang H, Vick GW, Mahmarian JJ, Verani MS. Evaluation of left ventricular wall motion, volumes, and ejection fraction by gated myocardial tomography with technetium 99m-labeled tetrofosmin: a comparison with cine magnetic resonance imaging. J Nucl Cardiol 1998;6:3–10.

    Article  Google Scholar 

  7. Bax JJ, Lamb H, Dibbets P, et al. Comparison of gated single-photon emission computed tomography with magnetic resonance imaging for evaluation of left ventricular function in ischemic cardiomyopathy. Am J Cardiol 2000;86:1299–305.

    Article  PubMed  CAS  Google Scholar 

  8. Vallejo E, Cione D, Bruni WL, et al. Reproducibility and accuracy of gated SPECT for determination of left ventricular volumes and ejection fraction: experimental validation using MRI. J Nucl Med 2000;41:874–82.

    PubMed  CAS  Google Scholar 

  9. Case J, Bateman T, Cullom SJ, et al. Improved accuracy of SPECT LVEF using numerical modeling of ventricular image blurring for patients with small hearts [abstract]. J Am Coll Cardiol 1999;33:436A.

    Article  Google Scholar 

  10. Cohade C, Taillefer R, Gagnon A, Lajeunesse S, Benjamin C. Effect of the number of frames per cardiac cycle and the amount of injected does of radionuclide on the determination of left ventricular ejection fraction with gated SPECT myocardial perfusion imaging [abstract]. J Nucl Med 2000;41(suppl):154P.

    Google Scholar 

  11. Cooke CD, Garcia EV, Cullom SJ, et al. Determining the accuracy of calculating systolic wall thickening using a fast Fourier transform approximation: a simulation study based on canine and patient data. J Nucl Med 1994;35:1185–92.

    PubMed  CAS  Google Scholar 

  12. Galt JR, Garcia EV, Robbins WL. Effects of myocardial wall thickness on SPECT quantification. IEEE Trans Med Imaging 1990;9:144–50.

    Article  PubMed  CAS  Google Scholar 

  13. Sinha S, Mather R, Sinha U, et al. Estimation of the left ventricular ejection fraction using a novel multiphase, dark-blood, breath-hold MR imaging technique. AJR Am J Roentgenol 1997;169:101–12.

    PubMed  CAS  Google Scholar 

  14. Baur LHB, Schipperheyn JJ, van der Velde EA, et al. Reproducibility of left ventricular size, shape and mass with echocardiography, magnetic resonance imaging, and radionuclide angiography in patients with anterior wall infarction. A plea for core laboratories. Int J Card Imaging 1996;12:233–40.

    Article  PubMed  CAS  Google Scholar 

  15. Semelka RC, Tomei E, Wagner S, et al. Interstudy reproducibility of dimensional and functional measurements between cine magnetic resonance studies in the morphologically abnormal left ventricle. Am Heart J 1990;119:1367–73.

    Article  PubMed  CAS  Google Scholar 

  16. Johnson LL, Verdesca SA, Aude WY, et al. Postischemic stunning can affect left ventricular ejection fraction and regional wall motion on post-stress gated sestamibi tomograms. J Am Coll Cardiol 1997;30:1641–8.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Radiology, Division of Nuclear Medicine, Emory University School of Medicine, 1364 Clifton Road, NE, 30322, Atlanta, GA

    Tracy L. Faber, Johnathan P. Vansant, Roderic I. Pettigrew, James R. Galt, Michel Blais, C. David Cooke, Russell D. Folks, Sandra M. Waldrop, Elzbieta Gurtler-Krawczynska & Ernest V. Garcia

  2. Department of Chemical Engineering, Cleveland State University, Cleveland, Ohio

    George Chatzimavroudis

  3. Division of Nuclear Medicine, St Louis University, St Louis, Mo

    Mark D. Wittry

Authors
  1. Tracy L. Faber
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  2. Johnathan P. Vansant
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  3. Roderic I. Pettigrew
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  4. James R. Galt
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  5. Michel Blais
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  6. George Chatzimavroudis
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  7. C. David Cooke
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  8. Russell D. Folks
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  9. Sandra M. Waldrop
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  10. Elzbieta Gurtler-Krawczynska
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  11. Mark D. Wittry
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  12. Ernest V. Garcia
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Corresponding author

Correspondence to Tracy L. Faber.

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Faber, T.L., Vansant, J.P., Pettigrew, R.I. et al. Evaluation of left ventricular endocardial volumes and ejection fractions computed from gated perfusion SPECT with magnetic resonance imaging: Comparison of two methods. J. Nucl. Cardiol. 8, 645–651 (2001). https://doi.org/10.1067/mnc.2001.117173

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  • DOI: https://doi.org/10.1067/mnc.2001.117173

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