Abstract
Emerging technological advances in genetics and neuroscience have spawned innovative or elaborated conceptual models in the field of addiction science, as well as contributed to the mushrooming of new knowledge. By addictions, reference is made to chronic, often relapsing disorders typified by obsession, compulsion or physical or psychological dependence. In this article it is proposed that a multilevel developmental contextual approach to substance use and addictions provides a useful framework for integrating existing studies across disciplines and serving as a generative guide to intriguing novel research questions. The multilevel developmental contextual approach emphasizes multiple-factor influences on substance use and addiction, the conjoint influence of variables from different levels of analysis (for example, genetic, biochemical, physiological, cognitive, social, neighborhood, societal), and dynamic, probabilistic behavior-outcome relations (that is, the occurrence as well as the nature of expression of substance problems and addiction depend on a range of emerging, interactive factors that may vary across individuals and over time). The approach is illustrated with a long-term prospective study of predictors of binge drinking from adolescence to young adulthood and a description of the role of brain processes and mechanisms involved in the development and expression of alcohol use during adolescence.
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References
Baltes, P.B. (1987) Theoretical propositions of life-span developmental psychology: On the dynamics between growth and decline. Developmental Psychology 23: 611–626.
Begleiter, H., Porjesz, B. and Kissin, B. (1984) Event-related brain potentials in boys at risk for alcoholism. Science 225: 1493–1496.
Blackson, T.C., Tarter, R.E., Loeber, R., Ammerman, R.T. and Windle, M. (1996) The influence of paternal substance abuse and difficult temperament in fathers and sons on sons’ disengagement from family to deviant peers. Journal of Youth and Adolescence 25: 389–411.
Bronfenbrenner, U. (1977) Toward an experimental ecology of human development. American Psychologist 32: 513–531.
De Bellis, M.D. et al (2000) Hippocampal volume in adolescent-onset alcohol use disorders. American Journal of Psychiatry 157 (5): 737–744.
De Bellis, M.D. et al (2001) Sex differences in brain maturation during childhood and adolescence. Cerebral Cortex 11 (6): 552–557.
Devor, E.J., Cloninger, R., Hoffman, P.L. and Takakoff, B. (1993) Association of monoamine (MAO) activity with alcoholism and alcoholic subtypes. American Journal of Medical Genetics 48: 209–213.
Dunn, J. (1980) Individual differences in temperament. In: M. Rutter (ed.) Scientific Foundations of Developmental Psychiatry. London: Heinemann Medical.
Giedd, J.N. et al (1999) Brain development during childhood and adolescence: A longitudinal MRI study. Nature Neuroscience 2 (10): 861–863.
Giedd, J.N., Castellanos, F.X., Rajapakse, J.C., Vaituzis, A.C. and Rapoport, J.L. (1997) Sexual dimorphism of the developing human brain. Progress in Neuropsychopharmacology and Biological Psychiatry 21 (8): 1185–1201.
Glahn, D.C., Lovallo, W.R. and Fox, P.T. (2007) Reduced amygdala activation in young adults at high risk of alcoholism: Studies from the Oklahoma Family Health Patterns Project. Biological Psychiatry 61: 1306–1309.
Goldman, D. (1995) Identifying alcoholism vulnerability alleles. Alcoholism: Clinical and Experimental Research 19: 824–831.
Gogtay, N. et al (2004) Dynamic mapping of human cortical development during childhood through early adulthood. Proceedings of the National Academy of Sciences of the United States of America 101 (21): 8174–8179.
Hall, R.L., Hesselbrock, V.M. and Stabenau, J.R. (1983) Familial distribution of alcohol use: II. Assortative mating of alcoholic probands. Behavior Genetics 13: 373–382.
Hill, S.Y. et al (2001) Right amygdala volume in adolescent and young adult offspring from families at high risk for developing alcoholism. Biological Psychiatry 49: 894–905.
Hill, S.Y. et al (2007) Cerebellar volume in offspring from multiplex alcohol dependence families. Biological Psychiatry 61: 41–47.
Keough, B. (1986) Temperament and schooling: Meaning of ‘goodness of fit’? In: J.V. Lerner and R.M. Lerner (eds.) New Directions for Child Development Vol. 31. Temperament and Social Interaction in Infants and Children. San Francisco: Jossey-Bass, pp. 89–108.
Lerner, R.M. (1982) Children and adolescents as producers of their own development. Development Review 2: 342–370.
Miller, P.M., Smith, G.T. and Goldman, M.S. (1990) Emergence of alcohol expectancies in childhood: A possible critical period. Journal of Studies on Alcohol 51: 343–349.
Russell, M. (1990) Prevalence of alcoholism among children of alcoholics. In: M. Windle and J.S. Searles (eds.) Children of Alcoholics: Critical Perspectives. New York: Guilford Press, pp 9–38.
Rutter, M. (1987) Psychosocial resilience and protective mechanisms. American Journal of Orthopsychiatry 57: 316–331.
Schuckit, M.A. (1994) A clinical model of genetic influences in alcohol dependence. Journal of Studies on Alcohol 55: 5–17.
Scriver, C.R. and Crow, C.L. (1980) Phenylketonuria: Epitome of human biochemical genetics (first of two parts). New England Journal of Medicine 303: 1336–1342.
Sher, K.J. (1991) Children of Alcoholics: A Critical Appraisal of Theory and Research. Chicago: University of Chicago Press.
Sowell, E.R., Thompson, P.M., Leonard, C.M., Welcome, S.E., Kan, E. and Toga, A.W. (2004) Longitudinal mapping of cortical thickness and brain growth in normal children. Journal of Neuroscience 24 (38): 8223–8231.
Tapert, S.F. and Schweinsburg, A.D. (2005) The human adolescent brain and alcohol use disorders. In: M. Galanter (ed.) Recent Developments in Alcoholism, Volume 17: Alcohol Problems in Adolescents and Young Adults. New York: Kluwer Academic/Plenum Publishers, pp. 177–189.
Toga, A.W. and Thompson, P.M. (2003) Temporal dynamics of brain anatomy. Annual Review of Biomedical Engineering 5: 119–145.
Tsuang, M.T., Faraone, S.V. and Lyons, M.J. (1993) Identification of the phenotype in psychiatric genetics. European Archives of Psychiatry and Clinical Neuroscience 682: 1–12.
Tubman, J.G. and Windle, M. (1995) Continuity of difficult temperament in adolescence: Relations with depression, life events, family support, and substance use across a one year period. Journal of Youth and Adolescence 24: 133–153.
Werner, E.E. (1986) Resilient offspring of alcoholics: A longitudinal study from birth to age 18. Journal of Studies on Alcohol 47: 34–40.
White, A.M. and Swartzwelder, H.S. (2005) Age-related effects of alcohol on memory and memory-related brain function in adolescents and adults. In: M. Galanter (ed.) Recent Developments in Alcoholism, Volume 17: Alcohol Problems in Adolescents and Young Adults. New York: Kluwer Academic/Plenum Publishers, pp. 161–176.
Windle, M. (1999) Alcohol Use Among Adolescents. Thousand Oaks, CA: Sage.
Windle, M., Mun, E.Y. and Windle, R.C. (2005) Adolescent-to-young adulthood heavy drinking trajectories and their prospective predictors. Journal of Studies on Alcohol 66: 313–322.
Windle, M. and Searles, J.S. (1990) Children of Alcoholics: Critical Perspectives. New York: Guilford Press.
Windle, M. et al (2008) Transitions into underage and problem drinking: Developmental processes and mechanisms between ages 10–15. Pediatrics 121 (54): S273–S289.
Zucker, R.A. (2006) Alcohol use and the alcohol use disorders: A developmental-biopsychosocial systems formulation covering the life course. In: D. Cicchetti and D.J. Cohen (eds.) Developmental Psychopathology 2nd Edition. New York: Wiley.
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This contribution was supported by the National Institute on Alcoholism and Alcohol Abuse Grant No. R01-AA07861 awarded to Michael Windle.
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Windle, M. A multilevel developmental contextual approach to substance use and addiction. BioSocieties 5, 124–136 (2010). https://doi.org/10.1057/biosoc.2009.9
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DOI: https://doi.org/10.1057/biosoc.2009.9